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IMD3 isopropylmalate dehydrogenase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 840006, updated on 18-Sep-2024

Summary

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Official Symbol
IMD3
Official Full Name
isopropylmalate dehydrogenase 3
Primary source
TAIR:AT1G31180
Locus tag
AT1G31180
See related
Araport:AT1G31180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS ISOPROPYLMALATE DEHYDROGENASE 3; ATIMD3; F28K20.14; F28K20_14; IPMDH1; ISOPROPYLMALATE DEHYDROGENASE 1; isopropylmalate dehydrogenase 3
Summary
The AtIMD3 is one out of 3 genes encoding the enzyme 3-isopropylmalate dehydrogenase involved in leucine biosynthesis in Arabidopsis. Its subcellular location has been targeted to plastids.
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Genomic context

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See IMD3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
8
Sequence:
Chromosome: 1; NC_003070.9 (11142461..11144717, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cytochrome C oxidase biogenesis Cmc1-like protein Neighboring gene myo-inositol monophosphatase like 1 Neighboring gene ncRNA Neighboring gene phloem protein 2-A9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and functional evolution of isopropylmalate dehydrogenases in the leucine and glucosinolate pathways of Arabidopsis thaliana. He Y, et al. J Biol Chem, 2011 Aug 19. PMID 21697089, Free PMC Article
  2. Functional characterization of Arabidopsis thaliana isopropylmalate dehydrogenases reveals their important roles in gametophyte development. He Y, et al. New Phytol, 2011 Jan. PMID 20840499
  3. Cloning of cDNAs encoding isopropylmalate dehydrogenase from Arabidopsis thaliana and accumulation patterns of their transcripts. Nozawa A, et al. Biosci Biotechnol Biochem, 2005 Apr. PMID 15849421
  4. The plastidic bile acid transporter 5 is required for the biosynthesis of methionine-derived glucosinolates in Arabidopsis thaliana. Gigolashvili T, et al. Plant Cell, 2009 Jun. PMID 19542295, Free PMC Article
  5. High light response of the thylakoid proteome in arabidopsis wild type and the ascorbate-deficient mutant vtc2-2. A comparative proteomics study. Giacomelli L, et al. Plant Physiol, 2006 Jun. PMID 16648217, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IPMDH2 and IPMDH3 primarily function in leucine biosynthesis, are essential for pollen development and are needed for proper embryo sac development.
    Title: Functional characterization of Arabidopsis thaliana isopropylmalate dehydrogenases reveals their important roles in gametophyte development.
  2. IPMDH is involved in leucine biosynthetic pathway. Three IPMDH ORF sequences designated as AtIMD1, AtIMD2, and AtIMD3 are localized in plastids. AtIMD3 transcripts were found mainly in flowers and cauline leaves. [AtIMD3; IPMDH]
    Title: Cloning of cDNAs encoding isopropylmalate dehydrogenase from Arabidopsis thaliana and accumulation patterns of their transcripts.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_102856.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 3-isopropylmalate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-isopropylmalate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-isopropylmalate dehydrogenase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables 3-isopropylmalate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-leucine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-leucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-leucine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in L-leucine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma HDA PubMed 
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in plastid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plastid ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in thylakoid HDA PubMed 

General protein information

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Preferred Names
isopropylmalate dehydrogenase 3
NP_174403.1
  • isopropylmalate dehydrogenase 3 (IMD3); FUNCTIONS IN: 3-isopropylmalate dehydrogenase activity; INVOLVED IN: leucine biosynthetic process, response to salt stress, metabolic process; LOCATED IN: thylakoid, chloroplast, chloroplast stroma, plastid; EXPRESSED IN: fruit, root, leaf; EXPRESSED DURING: seed development stages; CONTAINS InterPro DOMAIN/s: Isopropylmalate dehydrogenase (InterPro:IPR004429), Isocitrate/isopropylmalate dehydrogenase (InterPro:IPR001804), Isocitrate/isopropylmalate dehydrogenase, conserved site (InterPro:IPR019818); BEST Arabidopsis thaliana protein match is: isopropylmalate dehydrogenase 1 (TAIR:AT5G14200.1); Has 15253 Blast hits to 15253 proteins in 2616 species: Archae - 395; Bacteria - 8280; Metazoa - 576; Fungi - 831; Plants - 243; Viruses - 0; Other Eukaryotes - 4928 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    11142461..11144717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001332948.1 → NP_001322636.1  isopropylmalate dehydrogenase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AUM8, A0A5S9WH28, Q8LB97
    Conserved Domains (1) summary
    PLN02329
    Location:16 → 419
    PLN02329; 3-isopropylmalate dehydrogenase

  2. NM_102856.3 → NP_174403.1  isopropylmalate dehydrogenase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_174403.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1EBW0, Q9SA14
    UniProtKB/TrEMBL
    A0A178W4A1, A0A5S9WH28, Q8LB97
    Conserved Domains (1) summary
    PLN02329
    Location:1 → 404
    PLN02329; 3-isopropylmalate dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SA14.2

Gene LinkOut

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