IRX9-L Nucleotide-diphospho-sugar transferases superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: IRX9-L
Official Full Name: Nucleotide-diphospho-sugar transferases superfamily protein
Primary source: TAIR:AT1G27600
Locus tag: AT1G27600
See related: Araport:AT1G27600
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: I9H; IRREGULAR XYLEM 9 Homolog; IRREGULAR XYLEM 9-LIKE; T22C5.4
Summary: Encodes a member of the GT43 family glycosyltransferases involved in glucuronoxylan biosynthesis: AT2G37090 (IRX9) and AT1G27600 (IRX9-L or I9H, IRX9 homolog); AT4G36890 (IRX14) and AT5G67230 (IRX14-L or I14H, IRX14 homolog). They form two functionally non-redundant groups essential for the normal elongation of glucuronoxylan backbone. I9H functions redundantly with IRX9, I14H is redundant with IRX14. IRX9 or I9H do not complement IRX14, IRX14 or I14H do not complement IRX9.
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Genomic context

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See IRX9-L in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 5

Sequence:: Chromosome: 1; NC_003070.9 (9603178..9606247, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UPEX1 and IRX9L function in exine patterning in developing microspores by modulating the synthesis or modification of components of the primexine wall layer. Data support a model in which xylan and AGP cell wall components synthesized in tapetum are incorporated into the primexine wall and play roles in primexine development and anchoring of sporopollenin to the microspore surface early in microspore development. [IRX9L]
Title: Role of Glycosyltransferases in Pollen Wall Primexine Formation and Exine Patterning.
The putative glycosyltransferases IRX9, IRX14, and IRX10 (or the paralogs IRX9L, IRX14L, and IRX10L) are required for xylan backbone synthesis in Arabidopsis.
Title: Site-directed mutagenesis of IRX9, IRX9L and IRX14 proteins involved in xylan biosynthesis: glycosyltransferase activity is not required for IRX9 function in Arabidopsis.
The family GT43 glycosyltransferases form two functionally nonredundant groups, IRX9 together with I9H and IRX14 together with I14H, both of which are essential for GX biosynthesis. [I9H] [IRX9 homolog]
Title: The Arabidopsis family GT43 glycosyltransferases form two functionally nonredundant groups essential for the elongation of glucuronoxylan backbone.
IRX9-L and IRX14-L encode glycosyltransferase family 43 members that function during xylan backbone elongation. [IRX9-L]
Title: Analysis of the Arabidopsis IRX9/IRX9-L and IRX14/IRX14-L pairs of glycosyltransferase genes reveals critical contributions to biosynthesis of the hemicellulose glucuronoxylan.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_102525.3

Supported by ESTs:

NM_202193.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables xylosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucuronoxylan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type secondary cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen exine formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within xylan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Nucleotide-diphospho-sugar transferases superfamily protein

NP_564290.2

IRREGULAR XYLEM 9-LIKE (IRX9-L); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 43 (InterPro:IPR005027); BEST Arabidopsis thaliana protein match is: Nucleotide-diphospho-sugar transferases superfamily protein (TAIR:AT2G37090.1); Has 684 Blast hits to 682 proteins in 94 species: Archae - 0; Bacteria - 0; Metazoa - 425; Fungi - 0; Plants - 243; Viruses - 0; Other Eukaryotes - 16 (source: NCBI BLink).

NP_973922.1

IRREGULAR XYLEM 9-LIKE (IRX9-L); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 43 (InterPro:IPR005027); BEST Arabidopsis thaliana protein match is: Nucleotide-diphospho-sugar transferases superfamily protein (TAIR:AT2G37090.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

9603178..9606247 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_202193.1 → NP_973922.1 Nucleotide-diphospho-sugar transferases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_973922.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LD18, Q9SFZ7, Q9SXC4

UniProtKB/TrEMBL

A0A178W4D3, A0A384KPX8, A0A7G2DTD7, W8PW09

Conserved Domains (1) summary

cd00218
Location:141 → 372

GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis
NM_102525.3 → NP_564290.2 Nucleotide-diphospho-sugar transferases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564290.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LD18, Q9SFZ7, Q9SXC4

UniProtKB/TrEMBL

A0A178W4D3, A0A384KPX8, A0A7G2DTD7, W8PW09

Conserved Domains (1) summary

cd00218
Location:141 → 372

GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis