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Enpp5 ectonucleotide pyrophosphatase/phosphodiesterase 5 [ Mus musculus (house mouse) ]

Gene ID: 83965, updated on 2-Nov-2024

Summary

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Official Symbol
Enpp5provided by MGI
Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 5provided by MGI
Primary source
MGI:MGI:1933830
See related
Ensembl:ENSMUSG00000023960 AllianceGenome:MGI:1933830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E-NPP 5; D17Abb1e
Summary
Enables zinc ion binding activity. Predicted to be involved in cell communication. Predicted to act upstream of or within nucleotide catabolic process. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Orthologous to human ENPP5 (ectonucleotide pyrophosphatase/phosphodiesterase family member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in genital fat pad adult (RPKM 114.0), cerebellum adult (RPKM 52.7) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Enpp5 in Genome Data Viewer
Location:
17 B3; 17 20.3 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (44389693..44397458)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (44078802..44086567)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene regulator of calcineurin 2 Neighboring gene STARR-seq mESC enhancer starr_42606 Neighboring gene STARR-seq mESC enhancer starr_42607 Neighboring gene predicted gene, 34857 Neighboring gene predicted gene, 34917 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 4 Neighboring gene chloride intracellular channel 5 Neighboring gene STARR-seq mESC enhancer starr_42608 Neighboring gene STARR-positive B cell enhancer ABC_E5611

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain. Ohe Y, et al. Biochem Biophys Res Commun, 2003 Sep 5. PMID 12927778
  2. Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging. Takaya K, et al. Biogerontology, 2024 Jun. PMID 38436793
  3. A key tyrosine substitution restricts nucleotide hydrolysis by the ectoenzyme NPP5. Gorelik A, et al. FEBS J, 2017 Nov. PMID 28898552
  4. Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. Kasowitz SD, et al. PLoS Genet, 2018 May. PMID 29799838, Free PMC Article
  5. Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Chambers DM, et al. Genome Res, 1996 Aug. PMID 8858346

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging.
    Title: Regulation of ENPP5, a senescence-associated secretory phenotype factor, prevents skin aging.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

General gene information

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Markers

Homology

Clone Names

  • KIAA4152

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ diphosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables dinucleotide phosphatase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
  
involved_in cell communication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nucleotide catabolic process ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ectonucleotide pyrophosphatase/phosphodiesterase family member 5
NP_001162091.1
NP_001316547.1
NP_001316548.1
NP_001316549.1
NP_001316550.1
NP_001316551.1
NP_114392.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168620.2 → NP_001162091.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001162091.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF233377, AK032341, BC089320, BY232106, CT030230
    Consensus CDS
    CCDS28802.1
    UniProtKB/Swiss-Prot
    A9C479, Q921P7, Q9EQG7
    UniProtKB/TrEMBL
    Q5DTL0
    Related
    ENSMUSP00000122767.2, ENSMUST00000154166.8
    Conserved Domains (2) summary
    pfam01663
    Location:30 → 342
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:28 → 382
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  2. NM_001329618.1 → NP_001316547.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK032341, BC089320, BY232106, CT030230
    UniProtKB/TrEMBL
    Q5DTL0
    Conserved Domains (2) summary
    pfam01663
    Location:17 → 273
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:17 → 313
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  3. NM_001329619.1 → NP_001316548.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AF233377, BC089320, BY252780, CT030230
    UniProtKB/Swiss-Prot
    Q9EQG7
    UniProtKB/TrEMBL
    Q5FWJ8

  4. NM_001329620.1 → NP_001316549.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    BC089320, BC145484, BY252780, CT030230
    UniProtKB/TrEMBL
    Q5FWJ8

  5. NM_001329621.1 → NP_001316550.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    BC089320, BY257129, CT030230
    UniProtKB/TrEMBL
    Q5FWJ8

  6. NM_001329622.1 → NP_001316551.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    BC089320, BY232106, CT030230
    UniProtKB/TrEMBL
    Q5FWJ8

  7. NM_032003.3 → NP_114392.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_114392.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF233377, BC089320, BY252780, CT030230
    Consensus CDS
    CCDS28802.1
    UniProtKB/Swiss-Prot
    A9C479, Q921P7, Q9EQG7
    UniProtKB/TrEMBL
    Q5DTL0
    Related
    ENSMUSP00000024756.5, ENSMUST00000024756.5
    Conserved Domains (2) summary
    pfam01663
    Location:30 → 342
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:28 → 382
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    44389693..44397458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQG7.3 GenPept UniProtKB/Swiss-Prot:Q9EQG7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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