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Nrg4 neuregulin 4 [ Mus musculus (house mouse) ]

Gene ID: 83961, updated on 2-Nov-2024

Summary

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Official Symbol
Nrg4provided by MGI
Official Full Name
neuregulin 4provided by MGI
Primary source
MGI:MGI:1933833
See related
Ensembl:ENSMUSG00000032311 AllianceGenome:MGI:1933833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables receptor ligand activity. Involved in ERBB4-ERBB4 signaling pathway. Is active in extracellular space. Is expressed in several structures, including embryo mesenchyme; integumental system; pancreas; surface ectoderm; and uterus. Orthologous to human NRG4 (neuregulin 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in mammary gland adult (RPKM 13.4), subcutaneous fat pad adult (RPKM 12.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Nrg4 in Genome Data Viewer
Location:
9 B; 9 29.87 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55127506..55190937, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (55220222..55283654, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24182 Neighboring gene STARR-seq mESC enhancer starr_24183 Neighboring gene STARR-seq mESC enhancer starr_24184 Neighboring gene STARR-seq mESC enhancer starr_24185 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene ubiquitin-conjugating enzyme E2Q family member 2 Neighboring gene STARR-seq mESC enhancer starr_24186 Neighboring gene F-box protein 22 Neighboring gene STARR-positive B cell enhancer ABC_E9762 Neighboring gene serpine1 mRNA binding protein 1 pseudogene Neighboring gene transmembrane protein 266

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis. Chen Z, et al. JCI Insight, 2024 Jan 9. PMID 38015639, Free PMC Article
  2. Deletion of Endogenous Neuregulin-4 Limits Adaptive Immunity During Interleukin-10 Receptor-Neutralizing Colitis. Bernard JK, et al. Inflamm Bowel Dis, 2023 Nov 2. PMID 37265326, Free PMC Article
  3. Preventing High Fat Diet-induced Obesity and Improving Insulin Sensitivity through Neuregulin 4 Gene Transfer. Ma Y, et al. Sci Rep, 2016 May 17. PMID 27184920, Free PMC Article
  4. Adipocyte secreted NRG4 ameliorates age-associated metabolic dysfunction. Chen L, et al. Biochem Pharmacol, 2024 Jul. PMID 38823457
  5. Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice. Shi L, et al. Nat Metab, 2022 Nov. PMID 36400933, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adipocyte secreted NRG4 ameliorates age-associated metabolic dysfunction.
    Title: Adipocyte secreted NRG4 ameliorates age-associated metabolic dysfunction.
  2. Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis.
    Title: Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis.
  3. Deletion of Endogenous Neuregulin-4 Limits Adaptive Immunity During Interleukin-10 Receptor-Neutralizing Colitis.
    Title: Deletion of Endogenous Neuregulin-4 Limits Adaptive Immunity During Interleukin-10 Receptor-Neutralizing Colitis.
  4. Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis.
    Title: Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis.
  5. Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice.
    Title: Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice.
  6. Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway.
    Title: Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway.
  7. Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment.
    Title: Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment.
  8. Neuregulin 4 Attenuates Osteoarthritis Progression by Inhibiting Inflammation and Apoptosis of Chondrocytes in Mice.
    Title: Neuregulin 4 Attenuates Osteoarthritis Progression by Inhibiting Inflammation and Apoptosis of Chondrocytes in Mice.
  9. Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles.
    Title: Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles.
  10. Neuregulin-4 Is Required for Maintaining Soma Size of Pyramidal Neurons in the Motor Cortex.
    Title: Neuregulin-4 Is Required for Maintaining Soma Size of Pyramidal Neurons in the Motor Cortex.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables receptor ligand activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERBB4-ERBB4 signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pro-neuregulin-4, membrane-bound isoform
Names
pro-NRG4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001425100.1 → NP_001412029.1  pro-neuregulin-4, membrane-bound isoform isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157328

  2. NM_032002.3 → NP_114391.1  pro-neuregulin-4, membrane-bound isoform isoform 2

    See identical proteins and their annotated locations for NP_114391.1

    Status: VALIDATED

    Source sequence(s)
    AC157328
    Consensus CDS
    CCDS52801.1
    UniProtKB/Swiss-Prot
    Q9WTX4
    Related
    ENSMUSP00000130929.2, ENSMUST00000164721.8
    Conserved Domains (1) summary
    PHA03099
    Location:9 → 84
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

RNA

  1. NR_189137.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157328
    Related
    ENSMUST00000139261.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    55127506..55190937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313706.3 → XP_017169195.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/Swiss-Prot
    Q9WTX4
    Related
    ENSMUSP00000115247.2, ENSMUST00000130158.8
    Conserved Domains (1) summary
    PHA03099
    Location:9 → 84
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

  2. XM_017313705.3 → XP_017169194.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/Swiss-Prot
    Q9WTX4
    Conserved Domains (1) summary
    PHA03099
    Location:9 → 84
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional

  3. XM_017313704.2 → XP_017169193.1  pro-neuregulin-4, membrane-bound isoform isoform X1

    UniProtKB/Swiss-Prot
    Q9WTX4
    Conserved Domains (1) summary
    PHA03099
    Location:9 → 84
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTX4.1 GenPept UniProtKB/Swiss-Prot:Q9WTX4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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