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c-NAD-MDH1 Lactate/malate dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839527, updated on 18-Sep-2024

Summary

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Official Symbol
c-NAD-MDH1
Official Full Name
Lactate/malate dehydrogenase family protein
Primary source
TAIR:AT1G04410
Locus tag
AT1G04410
See related
Araport:AT1G04410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
cytosolic-NAD-dependent malate dehydrogenase 1; F19P19.13; F19P19_13
Summary
predicted to encode a cytosolic malate dehydrogenase.
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Genomic context

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See c-NAD-MDH1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
7
Sequence:
Chromosome: 1; NC_003070.9 (1188995..1191458, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene BTB/POZ domain-containing protein Neighboring gene cryptochrome 2 Neighboring gene NAD(P)-linked oxidoreductase superfamily protein Neighboring gene ncRNA Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Three cytosolic NAD-malate dehydrogenase isoforms of Arabidopsis thaliana: on the crossroad between energy fluxes and redox signaling. Liszka A, et al. Biochem J, 2020 Oct 16. PMID 32897311, Free PMC Article
  2. Determining novel functions of Arabidopsis 14-3-3 proteins in central metabolic processes. Diaz C, et al. BMC Syst Biol, 2011 Nov 21. PMID 22104211, Free PMC Article
  3. Protein disulfide isomerase-2 of Arabidopsis mediates protein folding and localizes to both the secretory pathway and nucleus, where it interacts with maternal effect embryo arrest factor. Cho EJ, et al. Mol Cells, 2011 Nov. PMID 21909944, Free PMC Article
  4. Identification of zinc-responsive proteins in the roots of Arabidopsis thaliana using a highly improved method of two-dimensional electrophoresis. Fukao Y, et al. Plant Cell Physiol, 2009 Dec. PMID 19880396
  5. Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis. Saracco SA, et al. Plant J, 2009 Jul. PMID 19292762, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Three cytosolic NAD-malate dehydrogenase isoforms of Arabidopsis thaliana: on the crossroad between energy fluxes and redox signaling.
    Title: Three cytosolic NAD-malate dehydrogenase isoforms of Arabidopsis thaliana: on the crossroad between energy fluxes and redox signaling.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_100321.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables L-malate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in malate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to zinc ion IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in Golgi apparatus RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in apoplast HDA PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in extracellular region HDA PubMed 
located_in nucleus HDA PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
Lactate/malate dehydrogenase family protein
NP_171936.1
  • Lactate/malate dehydrogenase family protein; FUNCTIONS IN: in 6 functions; INVOLVED IN: response to cadmium ion, response to zinc ion, response to salt stress; LOCATED IN: in 7 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Malate dehydrogenase, NAD-dependent, cytosolic (InterPro:IPR011274), Lactate/malate dehydrogenase, N-terminal (InterPro:IPR001236), Malate dehydrogenase, NAD/NADP (InterPro:IPR010945), Lactate/malate dehydrogenase, C-terminal (InterPro:IPR022383), NAD(P)-binding domain (InterPro:IPR016040), L-lactate/malate dehydrogenase (InterPro:IPR001557), Malate dehydrogenase, active site (InterPro:IPR001252), Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (InterPro:IPR015955); BEST Arabidopsis thaliana protein match is: Lactate/malate dehydrogenase family protein (TAIR:AT5G43330.1); Has 11998 Blast hits to 11997 proteins in 3022 species: Archae - 169; Bacteria - 7171; Metazoa - 1456; Fungi - 287; Plants - 683; Viruses - 0; Other Eukaryotes - 2232 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    1188995..1191458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_100321.3 → NP_171936.1  Lactate/malate dehydrogenase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_171936.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P93819
    UniProtKB/TrEMBL
    A0A178W4H0, A0A5S9SJ18, A0A654E708
    Conserved Domains (1) summary
    PLN00135
    Location:24 → 332
    PLN00135; malate dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P93819.2

Gene LinkOut

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