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Trps1 transcriptional repressor GATA binding 1 [ Mus musculus (house mouse) ]

Gene ID: 83925, updated on 2-Nov-2024

Summary

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Official Symbol
Trps1provided by MGI
Official Full Name
transcriptional repressor GATA binding 1provided by MGI
Primary source
MGI:MGI:1927616
See related
Ensembl:ENSMUSG00000038679 AllianceGenome:MGI:1927616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D15Ertd586e
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Involved in hair follicle development and regulation of chondrocyte differentiation. Acts upstream of or within several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; chondrocyte differentiation; and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and skin. Used to study trichorhinophalangeal syndrome type I. Human ortholog(s) of this gene implicated in osteochondrodysplasia; trichorhinophalangeal syndrome type I; and trichorhinophalangeal syndrome type III. Orthologous to human TRPS1 (transcriptional repressor GATA binding 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in limb E14.5 (RPKM 5.4), bladder adult (RPKM 4.0) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Trps1 in Genome Data Viewer
Location:
15 C; 15 19.18 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (50518149..50754027, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (50654757..50890631, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23848 Neighboring gene STARR-seq mESC enhancer starr_38628 Neighboring gene G2/mitotic-specific cyclin-B1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_38631 Neighboring gene STARR-seq mESC enhancer starr_38632 Neighboring gene STARR-seq mESC enhancer starr_38633 Neighboring gene STARR-seq mESC enhancer starr_38634 Neighboring gene STARR-seq mESC enhancer starr_38641 Neighboring gene STARR-seq mESC enhancer starr_38642 Neighboring gene STARR-seq mESC enhancer starr_38643 Neighboring gene microRNA 1907 Neighboring gene predicted gene, 48913 Neighboring gene predicted gene, 53881 Neighboring gene predicted gene, 34446

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity. Tollot-Wegner M, et al. Breast Cancer Res, 2024 May 3. PMID 38702730, Free PMC Article
  2. Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Suemoto H, et al. Dev Biol, 2007 Dec 15. PMID 17997399
  3. Dynamic expression of the zinc-finger transcription factor Trps1 during hair follicle morphogenesis and cycling. Fantauzzo KA, et al. Gene Expr Patterns, 2008 Jan. PMID 18054290
  4. A novel missense mutation in the TRPS1 gene in a case of trichorhinophalangeal syndrome type I (TRPS1) with fish-like malodour. Nakamura M, et al. J Eur Acad Dermatol Venereol, 2010 Mar. PMID 19694891
  5. Atypical GATA protein TRPS1 plays indispensable roles in mouse two-cell embryo. Liu Y, et al. Cell Cycle, 2019 Feb. PMID 30712485, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of Trps1 regulatory elements recapitulates postnatal hip joint abnormalities and growth retardation of Trichorhinophalangeal syndrome in mice.
    Title: Deletion of Trps1 regulatory elements recapitulates postnatal hip joint abnormalities and growth retardation of Trichorhinophalangeal syndrome in mice.
  2. TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity.
    Title: TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity.
  3. Cis-regulatory control of mammalian Trps1 gene expression.
    Title: Cis-regulatory control of mammalian Trps1 gene expression.
  4. Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells.
    Title: Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells.
  5. Trps1 transcription factor represses phosphate-induced expression of SerpinB2 in osteogenic cells.
    Title: Trps1 transcription factor represses phosphate-induced expression of SerpinB2 in osteogenic cells.
  6. Study characterized the murine Wnt5a promoter and showed that two alternative Wnt5a transcripts, Ts1 and Ts2, are differentially expressed in the developing skeletal elements. Ts2 expression decreases while Ts1 expression increases during chondrocyte differentiation. The transcription factor Trps1 and the activator form of Gli3 (Gli3A), which is a mediator of Hedgehog signaling, activate Wnt5a expression.
    Title: Wnt5a is a transcriptional target of Gli3 and Trps1 at the onset of chondrocyte hypertrophy.
  7. These results demonstrated that TRPS1 plays indispensable roles during mouse zygotic genome activation through controlling the expression of zygotic genome activation markers MuERV-L and Zscan4d, transcription factors SOX2 and OCT4, and key histone markers H3K4me3 and H3K27me3.
    Title: Atypical GATA protein TRPS1 plays indispensable roles in mouse two-cell embryo.
  8. TRPS1 can function as a context-dependent tumor suppressor in breast cancer, while being essential for growth and differentiation of normal mammary epithelial cells.
    Title: TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development.
  9. This study has demonstrated that Trps1 is a positive regulator of cell proliferation in both dental mesenchyme and epithelium, suggesting that the microdontia in trichorhinophalangeal syndrome is likely due to decreased cell proliferation in developing tooth organs.
    Title: Trps1 transcription factor regulates mineralization of dental tissues and proliferation of tooth organ cells.
  10. our findings partially explain why patients with TRPS show a broad range of congenital cardiac defects, although Trps1 expression is observed in a more restricted fashion.
    Title: Fate mapping of Trps1 daughter cells during cardiac development using novel Trps1-Cre mice.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (6) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC46754, MGC107472

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hair follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger transcription factor Trps1
Names
trichorhinophalangeal syndrome I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310481.1 → NP_001297410.1  zinc finger transcription factor Trps1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC155307, AK142355, CN667090, DV651380
    Consensus CDS
    CCDS79370.1
    UniProtKB/TrEMBL
    Q499D6, V9GX74
    Related
    ENSMUSP00000139017.2, ENSMUST00000183757.8
    Conserved Domains (2) summary
    smart00401
    Location:895 → 938
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:899 → 955
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  2. NM_001310485.1 → NP_001297414.1  zinc finger transcription factor Trps1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is alternatively spliced in the 5' region and contains an additional in-frame exon compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC155307, AK142355, CN667090, DV651380
    Consensus CDS
    CCDS79371.1
    UniProtKB/TrEMBL
    Q80V18, V9GXE9
    Related
    ENSMUSP00000139115.2, ENSMUST00000183997.8
    Conserved Domains (2) summary
    smart00401
    Location:706 → 749
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:710 → 766
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  3. NM_032000.2 → NP_114389.2  zinc finger transcription factor Trps1 isoform 2

    See identical proteins and their annotated locations for NP_114389.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is alternatively spliced at the 5' end and uses an in-frame, downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC142245, AC155307, DV651380
    Consensus CDS
    CCDS27460.1
    UniProtKB/TrEMBL
    G3UW90, Q499D6
    Related
    ENSMUSP00000129779.2, ENSMUST00000165201.9
    Conserved Domains (1) summary
    cd00202
    Location:895 → 951
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    50518149..50754027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159653.1 → XP_036015546.1  zinc finger transcription factor Trps1 isoform X6

    UniProtKB/TrEMBL
    Q80V18
    Related
    ENSMUSP00000138905.2, ENSMUST00000184885.8
    Conserved Domains (1) summary
    cd00202
    Location:695 → 751
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  2. XM_011245780.4 → XP_011244082.1  zinc finger transcription factor Trps1 isoform X2

    See identical proteins and their annotated locations for XP_011244082.1

    UniProtKB/TrEMBL
    Q499D6
    Conserved Domains (1) summary
    cd00202
    Location:906 → 962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  3. XM_036159648.1 → XP_036015541.1  zinc finger transcription factor Trps1 isoform X2

    UniProtKB/TrEMBL
    Q499D6
    Conserved Domains (1) summary
    cd00202
    Location:906 → 962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  4. XM_036159651.1 → XP_036015544.1  zinc finger transcription factor Trps1 isoform X4

    UniProtKB/TrEMBL
    Q80V18, Q8K1J0
    Conserved Domains (1) summary
    cd00202
    Location:706 → 762
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  5. XM_036159652.1 → XP_036015545.1  zinc finger transcription factor Trps1 isoform X6

    UniProtKB/TrEMBL
    Q80V18
    Conserved Domains (1) summary
    cd00202
    Location:695 → 751
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  6. XM_030248828.2 → XP_030104688.1  zinc finger transcription factor Trps1 isoform X4

    UniProtKB/TrEMBL
    Q80V18, Q8K1J0
    Conserved Domains (1) summary
    cd00202
    Location:706 → 762
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  7. XM_011245776.4 → XP_011244078.1  zinc finger transcription factor Trps1 isoform X2

    See identical proteins and their annotated locations for XP_011244078.1

    UniProtKB/TrEMBL
    Q499D6
    Conserved Domains (1) summary
    cd00202
    Location:906 → 962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  8. XM_036159650.1 → XP_036015543.1  zinc finger transcription factor Trps1 isoform X4

    UniProtKB/TrEMBL
    Q80V18, Q8K1J0
    Conserved Domains (1) summary
    cd00202
    Location:706 → 762
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  9. XM_036159649.1 → XP_036015542.1  zinc finger transcription factor Trps1 isoform X3

    UniProtKB/TrEMBL
    G3UW90, Q499D6
    Conserved Domains (1) summary
    cd00202
    Location:895 → 951
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  10. XM_011245778.4 → XP_011244080.1  zinc finger transcription factor Trps1 isoform X2

    See identical proteins and their annotated locations for XP_011244080.1

    UniProtKB/TrEMBL
    Q499D6
    Conserved Domains (1) summary
    cd00202
    Location:906 → 962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  11. XM_006521560.4 → XP_006521623.1  zinc finger transcription factor Trps1 isoform X1

    UniProtKB/TrEMBL
    Q499D6
    Conserved Domains (1) summary
    cd00202
    Location:910 → 966
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  12. XM_030248826.2 → XP_030104686.1  zinc finger transcription factor Trps1 isoform X2

    UniProtKB/TrEMBL
    Q499D6
    Conserved Domains (1) summary
    cd00202
    Location:906 → 962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  13. XM_006521563.4 → XP_006521626.1  zinc finger transcription factor Trps1 isoform X5

    UniProtKB/TrEMBL
    Q80V18
    Conserved Domains (1) summary
    cd00202
    Location:699 → 755
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  14. XM_036159645.1 → XP_036015538.1  zinc finger transcription factor Trps1 isoform X2

    UniProtKB/TrEMBL
    Q499D6
    Conserved Domains (1) summary
    cd00202
    Location:906 → 962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  15. XM_011245777.3 → XP_011244079.1  zinc finger transcription factor Trps1 isoform X2

    See identical proteins and their annotated locations for XP_011244079.1

    UniProtKB/TrEMBL
    Q499D6
    Conserved Domains (1) summary
    cd00202
    Location:906 → 962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  16. XM_036159647.1 → XP_036015540.1  zinc finger transcription factor Trps1 isoform X2

    UniProtKB/TrEMBL
    Q499D6
    Conserved Domains (1) summary
    cd00202
    Location:906 → 962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  17. XM_036159646.1 → XP_036015539.1  zinc finger transcription factor Trps1 isoform X2

    UniProtKB/TrEMBL
    Q499D6
    Conserved Domains (1) summary
    cd00202
    Location:906 → 962
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925H1.1 GenPept UniProtKB/Swiss-Prot:Q925H1

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