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Cemip2 cell migration inducing hyaluronidase 2 [ Mus musculus (house mouse) ]

Gene ID: 83921, updated on 2-Nov-2024

Summary

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Official Symbol
Cemip2provided by MGI
Official Full Name
cell migration inducing hyaluronidase 2provided by MGI
Primary source
MGI:MGI:1890373
See related
Ensembl:ENSMUSG00000024754 AllianceGenome:MGI:1890373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem2
Summary
Enables hyalurononglucosaminidase activity. Involved in hyaluronan catabolic process. Predicted to be located in cytosol; nucleolus; and plasma membrane. Is expressed in several structures, including heart; integumental system; nervous system; sensory organ; and tooth. Orthologous to human CEMIP2 (cell migration inducing hyaluronidase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 15.6), CNS E11.5 (RPKM 14.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Cemip2 in Genome Data Viewer
Location:
19 B; 19 15.54 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (21755704..21835724)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (21778340..21858360)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr19:21788111-21788412 Neighboring gene abhydrolase domain containing 17B Neighboring gene STARR-positive B cell enhancer ABC_E9993 Neighboring gene STARR-positive B cell enhancer ABC_E9994 Neighboring gene VISTA enhancer mm1610 Neighboring gene STARR-seq mESC enhancer starr_45737 Neighboring gene STARR-seq mESC enhancer starr_45738 Neighboring gene predicted gene, 41818 Neighboring gene STARR-seq mESC enhancer starr_45740 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene lactate dehydrogenase B, pseudogene Neighboring gene STARR-seq mESC enhancer starr_45741 Neighboring gene STARR-seq mESC enhancer starr_45742 Neighboring gene transient receptor potential cation channel, subfamily M, member 3 Neighboring gene predicted gene, 22506

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TMEM2 inhibits the development of Graves' orbitopathy through the JAK-STAT signaling pathway. Li H, et al. J Biol Chem, 2024 Feb. PMID 38159864, Free PMC Article
  2. The cell surface hyaluronidase TMEM2 is essential for systemic hyaluronan catabolism and turnover. Tobisawa Y, et al. J Biol Chem, 2021 Nov. PMID 34624311, Free PMC Article
  3. The cell surface hyaluronidase TMEM2 regulates cell adhesion and migration via degradation of hyaluronan at focal adhesion sites. Irie F, et al. J Biol Chem, 2021 Jan-Jun. PMID 33647313, Free PMC Article
  4. TMEM2 is a bona fide hyaluronidase possessing intrinsic catalytic activity. Narita T, et al. J Biol Chem, 2023 Sep. PMID 37527776, Free PMC Article
  5. Hyaluronic acid and its receptor CD44, acting through TMEM2, inhibit morphological differentiation in oligodendroglial cells. Sato T, et al. Biochem Biophys Res Commun, 2022 Oct 8. PMID 35940122

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM2 inhibits the development of Graves' orbitopathy through the JAK-STAT signaling pathway.
    Title: TMEM2 inhibits the development of Graves' orbitopathy through the JAK-STAT signaling pathway.
  2. HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion.
    Title: HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion.
  3. TMEM2 is a bona fide hyaluronidase possessing intrinsic catalytic activity.
    Title: TMEM2 is a bona fide hyaluronidase possessing intrinsic catalytic activity.
  4. Tmem2 Deficiency Leads to Enamel Hypoplasia and Soft Enamel in Mouse.
    Title: Tmem2 Deficiency Leads to Enamel Hypoplasia and Soft Enamel in Mouse.
  5. Hyaluronic acid and its receptor CD44, acting through TMEM2, inhibit morphological differentiation in oligodendroglial cells.
    Title: Hyaluronic acid and its receptor CD44, acting through TMEM2, inhibit morphological differentiation in oligodendroglial cells.
  6. The cell surface hyaluronidase TMEM2 plays an essential role in mouse neural crest cell development and survival.
    Title: The cell surface hyaluronidase TMEM2 plays an essential role in mouse neural crest cell development and survival.
  7. The cell surface hyaluronidase TMEM2 is essential for systemic hyaluronan catabolism and turnover.
    Title: The cell surface hyaluronidase TMEM2 is essential for systemic hyaluronan catabolism and turnover.
  8. The cell surface hyaluronidase TMEM2 regulates cell adhesion and migration via degradation of hyaluronan at focal adhesion sites.
    Title: The cell surface hyaluronidase TMEM2 regulates cell adhesion and migration via degradation of hyaluronan at focal adhesion sites.
  9. these data suggest that TMEM2 is the long-sought-after hyaluronidase that cleaves extracellular HMW-HA into intermediate-size fragments before internalization and degradation in the lysosome.
    Title: A mammalian homolog of the zebrafish transmembrane protein 2 (TMEM2) is the long-sought-after cell-surface hyaluronidase.
  10. immature AVC expansion in wkm mutants is rescued by depleting Bmp4, indicating that Tmem2 restricts bmp4 expression to delimit the AVC primordium during cardiac development
    Title: Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102198, mKIAA1412, 3110012M15Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables hyalurononglucosaminidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in hyaluronan catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cell surface hyaluronidase
Names
transmembrane protein 2
NP_001028931.1
NP_114386.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033759.2 → NP_001028931.1  cell surface hyaluronidase

    See identical proteins and their annotated locations for NP_001028931.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK034906, AK078530, BC089353, BU058152
    Consensus CDS
    CCDS37934.1
    UniProtKB/Swiss-Prot
    Q3UE15, Q3UE98, Q5FWI3, Q6DFZ0, Q6ZPR7, Q8VE53, Q9QY22
    Related
    ENSMUSP00000025663.7, ENSMUST00000025663.8
    Conserved Domains (3) summary
    cd13938
    Location:220 → 387
    PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
    pfam10162
    Location:123 → 244
    G8; G8 domain
    pfam15711
    Location:1244 → 1333
    ILEI; Interleukin-like EMT inducer

  2. NM_031997.4 → NP_114386.3  cell surface hyaluronidase

    See identical proteins and their annotated locations for NP_114386.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK034906, AK078530, AK149667, BC089353, BU058152
    Consensus CDS
    CCDS37934.1
    UniProtKB/Swiss-Prot
    Q3UE15, Q3UE98, Q5FWI3, Q6DFZ0, Q6ZPR7, Q8VE53, Q9QY22
    Related
    ENSMUSP00000093908.3, ENSMUST00000096194.9
    Conserved Domains (3) summary
    cd13938
    Location:220 → 387
    PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
    pfam10162
    Location:123 → 244
    G8; G8 domain
    pfam15711
    Location:1244 → 1333
    ILEI; Interleukin-like EMT inducer

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    21755704..21835724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FWI3.1 GenPept UniProtKB/Swiss-Prot:Q5FWI3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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