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TPX2 targeting protein for XKLP2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839140, updated on 18-Sep-2024

Summary

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Official Symbol
TPX2
Official Full Name
targeting protein for XKLP2
Primary source
TAIR:AT1G03780
Locus tag
AT1G03780
See related
Araport:AT1G03780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtTPX2; F21M11.31; F21M11_31; targeting protein for XKLP2
Summary
Homolog of vertebrate TPX2. Protein has three domains involved in nuclear targeting, one in nuclear export and two in microtubule binding. Involved in mitotic spindle assembly during late prophase and early prometaphase.
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Genomic context

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See TPX2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
17
Sequence:
Chromosome: 1; NC_003070.9 (947520..951850, complement)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene switch 2 Neighboring gene Prefoldin chaperone subunit family protein Neighboring gene RING 1B Neighboring gene Zinc finger C-x8-C-x5-C-x3-H type family protein Neighboring gene ERF domain protein 10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aberrant microtubule organization in dividing root cells of p60-katanin mutants. Panteris E, et al. Plant Signal Behav, 2012 Jan. PMID 22301959, Free PMC Article
  2. The plant TPX2 protein regulates prospindle assembly before nuclear envelope breakdown. Vos JW, et al. Plant Cell, 2008 Oct. PMID 18941054, Free PMC Article
  3. Overexpressed TPX2 causes ectopic formation of microtubular arrays in the nuclei of acentrosomal plant cells. Petrovská B, et al. J Exp Bot, 2013 Nov. PMID 24006426, Free PMC Article
  4. Plant Aurora kinases play a role in maintenance of primary meristems and control of endoreduplication. Petrovská B, et al. New Phytol, 2012 Feb. PMID 22150830
  5. Functional Divergence of Microtubule-Associated TPX2 Family Members in Arabidopsis thaliana. Dvořák Tomaštíková E, et al. Int J Mol Sci, 2020 Mar 22. PMID 32235723, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional Divergence of Microtubule-Associated TPX2 Family Members in Arabidopsis thaliana.
    Title: Functional Divergence of Microtubule-Associated TPX2 Family Members in Arabidopsis thaliana.
  2. Overexpressed AtTPX2 reinforces microtubule formation in the vicinity of chromatin and the nuclear envelope.
    Title: Overexpressed TPX2 causes ectopic formation of microtubular arrays in the nuclei of acentrosomal plant cells.
  3. show that the Targeting Protein for Xklp2 (TPX2) protein co-localizes with microtubules on the surface of prophase nuclei of the mutants, probably participating in multipolar spindle assembly
    Title: Aberrant microtubule organization in dividing root cells of p60-katanin mutants.
  4. TPX2 is localized to the cell nucleus and microtubules, and has a role in proper spindle assembly.
    Title: The plant TPX2 protein regulates prospindle assembly before nuclear envelope breakdown.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_100257.3
NM_202025.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast envelope HDA PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in phragmoplast IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in spindle IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
targeting protein for XKLP2
NP_001184902.1
  • targeting protein for XKLP2 (TPX2); FUNCTIONS IN: microtubule binding; INVOLVED IN: spindle assembly; LOCATED IN: nucleus; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Cell cycle regulated microtubule associated protein (InterPro:IPR022021), Xklp2 targeting protein (InterPro:IPR009675); BEST Arabidopsis thaliana protein match is: TPX2 (targeting protein for Xklp2) protein family (TAIR:AT5G44270.1).
NP_171874.3
  • targeting protein for XKLP2 (TPX2); FUNCTIONS IN: microtubule binding; INVOLVED IN: spindle assembly; LOCATED IN: nucleus, chloroplast envelope; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Cell cycle regulated microtubule associated protein (InterPro:IPR022021); BEST Arabidopsis thaliana protein match is: Cell cycle regulated microtubule associated protein (TAIR:AT4G22860.2); Has 864 Blast hits to 721 proteins in 133 species: Archae - 2; Bacteria - 40; Metazoa - 457; Fungi - 40; Plants - 113; Viruses - 0; Other Eukaryotes - 212 (source: NCBI BLink).
NP_973754.2
  • targeting protein for XKLP2 (TPX2); CONTAINS InterPro DOMAIN/s: Cell cycle regulated microtubule associated protein (InterPro:IPR022021), Xklp2 targeting protein (InterPro:IPR009675); BEST Arabidopsis thaliana protein match is: TPX2 (targeting protein for Xklp2) protein family (TAIR:AT5G44270.1); Has 2017 Blast hits to 1530 proteins in 221 species: Archae - 5; Bacteria - 108; Metazoa - 882; Fungi - 144; Plants - 344; Viruses - 0; Other Eukaryotes - 534 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    947520..951850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001197973.1 → NP_001184902.1  targeting protein for XKLP2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001184902.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4I2H7, F4I2H9, Q3EDJ2, Q56XS5, Q9ZWA0
    Conserved Domains (2) summary
    pfam06886
    Location:652 → 705
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam12214
    Location:315 → 487
    TPX2_importin; Cell cycle regulated microtubule associated protein

  2. NM_202025.3 → NP_973754.2  targeting protein for XKLP2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973754.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WE47, A0A5S9SFC0
    Conserved Domains (2) summary
    pfam06886
    Location:647 → 728
    TPX2; Targeting protein for Xklp2 (TPX2)
    pfam12214
    Location:320 → 487
    TPX2_importin; Cell cycle regulated microtubule associated protein

  3. NM_100257.3 → NP_171874.3  targeting protein for XKLP2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_171874.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4I2H7
    Conserved Domains (1) summary
    pfam12214
    Location:315 → 466
    TPX2_importin; Cell cycle regulated microtubule associated protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4I2H7.1

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