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WDR87 WD repeat domain 87 [ Homo sapiens (human) ]

Gene ID: 83889, updated on 3-Apr-2024

Summary

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Official Symbol
WDR87provided by HGNC
Official Full Name
WD repeat domain 87provided by HGNC
Primary source
HGNC:HGNC:29934
See related
Ensembl:ENSG00000171804 MIM:620274; AllianceGenome:HGNC:29934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NYD-SP11
Expression
Restricted expression toward testis (RPKM 11.3) See more
Orthologs
mouse all
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Genomic context

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Location:
19q13.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37884823..37906697, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40686877..40708749, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38375463..38397234, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38307709-38308210 Neighboring gene uncharacterized LOC644554 Neighboring gene Sharpr-MPRA regulatory region 13711 Neighboring gene WD repeat domain 87 pseudogene Neighboring gene WD repeat domain 87B, pseudogene Neighboring gene uncharacterized LOC105372395 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38353930-38354430 Neighboring gene uncharacterized LOC107985301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38405529-38406394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38406395-38407260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38423536-38424198 Neighboring gene signal induced proliferation associated 1 like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10561 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38453618-38454118 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14563 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38472499-38473000 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38479003-38479508 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38479509-38480014 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38480015-38480522 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38480523-38481028 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38481029-38481534 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:38489623-38490822 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38494121-38494652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14564 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14565 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38503265-38503837 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38515553-38516056 Neighboring gene uncharacterized LOC105372396 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38516057-38516560 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38527685-38528186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14567 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:38538329-38539077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14568 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38542997-38543498 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38546196-38546766 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38561125-38561626 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38561627-38562126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38565075-38565574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38572086-38572639 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38602551-38603168 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:38609967-38610170 Neighboring gene MPRA-validated peak3469 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38620740-38621240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38621241-38621741 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:38623222-38623722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38634171-38635020 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:38648368-38648546 Neighboring gene small nucleolar RNA, C/D box 152

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. WDR87 interacts with CFAP47 protein in the middle piece of spermatozoa flagella to participate in sperm tail assembly. Liao HQ, et al. Mol Hum Reprod, 2022 Dec 28. PMID 36571501
  2. Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients. Zhang YK, et al. Nat Commun, 2017 Sep 6. PMID 28878358, Free PMC Article
  3. Physiological and pathophysiological characteristics of ataxin-3 isoforms. Weishäupl D, et al. J Biol Chem, 2019 Jan 11. PMID 30455355, Free PMC Article
  4. Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53. Guo Y, et al. Cell Death Dis, 2021 Oct 14. PMID 34650049, Free PMC Article
  5. Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers. Rosenbluh J, et al. Cell Syst, 2016 Sep 28. PMID 27684187, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WDR87 interacts with CFAP47 protein in the middle piece of spermatozoa flagella to participate in sperm tail assembly.
    Title: WDR87 interacts with CFAP47 protein in the middle piece of spermatozoa flagella to participate in sperm tail assembly.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ52608

General protein information

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Preferred Names
WD repeat-containing protein 87
Names
testis development protein NYD-SP11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291088.2 → NP_001278017.1  WD repeat-containing protein 87 isoform 1

    See identical proteins and their annotated locations for NP_001278017.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
    Source sequence(s)
    ABBA01040648, AC016582, AK302913
    Consensus CDS
    CCDS74356.1
    UniProtKB/TrEMBL
    A0AA75ISB7
    Related
    ENSP00000405012.2, ENST00000447313.7
    Conserved Domains (6) summary
    COG1340
    Location:1628 → 1920
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    COG2319
    Location:251 → 646
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:202 → 238
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:252 → 531
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl15838
    Location:1621 → 1744
    Phage_GPO; Phage capsid scaffolding protein (GPO) serine peptidase
    cl19219
    Location:1834 → 1920
    DUF342; Protein of unknown function (DUF342)

  2. NM_031951.5 → NP_114157.4  WD repeat-containing protein 87 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    ABBA01040648, AC016582, AK128826, HY010892
    Consensus CDS
    CCDS46063.1
    UniProtKB/Swiss-Prot
    E7ESW6, Q6ZQQ6, Q9BWV9
    Related
    ENSP00000368025.3, ENST00000303868.5
    Conserved Domains (4) summary
    PTZ00121
    Location:1345 → 2117
    PTZ00121; MAEBL; Provisional
    COG2319
    Location:212 → 607
    WD40; WD40 repeat [General function prediction only]
    PRK12704
    Location:2073 → 2174
    PRK12704; phosphodiesterase; Provisional
    sd00039
    Location:163 → 199
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    37884823..37906697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439499.1 → XP_047295455.1  WD repeat-containing protein 87 isoform X2

  2. XM_011527360.3 → XP_011525662.2  WD repeat-containing protein 87 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    40686877..40708749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322303.1 → XP_054178278.1  WD repeat-containing protein 87 isoform X2

  2. XM_054322302.1 → XP_054178277.1  WD repeat-containing protein 87 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQQ6.4 GenPept UniProtKB/Swiss-Prot:Q6ZQQ6

Gene LinkOut

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