CNGC10 cyclic nucleotide gated channel 10 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CNGC10
Official Full Name: cyclic nucleotide gated channel 10
Primary source: TAIR:AT1G01340
Locus tag: AT1G01340
See related: Araport:AT1G01340
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACBK1; ATCNGC10; cyclic nucleotide gated channel 10; F6F3.13; F6F3_13
Summary: member of Cyclic nucleotide gated channel family
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Genomic context

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See CNGC10 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 9

Sequence:: Chromosome: 1; NC_003070.9 (132270..135924, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that CNGC10 negatively regulates salt tolerance in A. thaliana and may be involved in mediating Na(+) transport.
Title: Cyclic nucleotide gated channel 10 negatively regulates salt tolerance by mediating Na+ transport in Arabidopsis.
AtCNGC10 is involved in in Ca2+ and Mg2+ transport, which, in turn, regulates K+ transport.
Title: The cyclic nucleotide-gated channel AtCNGC10 transports Ca2+ and Mg2+ in Arabidopsis.
The AtCNGC10 channel is involved in Na+ and K+ transport during cation uptake in roots and in long-distance transport.
Title: The cyclic nucleotide-gated channel, AtCNGC10, influences salt tolerance in Arabidopsis.
AtCNGC10 traffics from the endoplasmic reticulum via the Golgi apparatus and associated vesicles to the plasma membrane.
Title: The cyclic nucleotide gated cation channel AtCNGC10 traffics from the ER via Golgi vesicles to the plasma membrane of Arabidopsis root and leaf cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001197956.2

Supported by ESTs:

NM_100016.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: cyclic nucleotide gated channel 10

NP_001184885.1

cyclic nucleotide gated channel 10 (CNGC10); FUNCTIONS IN: ion channel activity, cyclic nucleotide binding, calmodulin binding; INVOLVED IN: ion transport, transmembrane transport; LOCATED IN: membrane; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Cyclic nucleotide-binding-like (InterPro:IPR018490), Ion transport (InterPro:IPR005821), RmlC-like jelly roll fold (InterPro:IPR014710), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: cyclic nucleotide-gated channel 13 (TAIR:AT4G01010.1).

NP_563625.1

cyclic nucleotide gated channel 10 (CNGC10); FUNCTIONS IN: ion channel activity, cyclic nucleotide binding, calmodulin binding; INVOLVED IN: ion transport, transmembrane transport; LOCATED IN: membrane; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: cyclic nucleotide-gated channel 13 (TAIR:AT4G01010.1); Has 3364 Blast hits to 3209 proteins in 253 species: Archae - 0; Bacteria - 35; Metazoa - 1554; Fungi - 48; Plants - 1027; Viruses - 0; Other Eukaryotes - 700 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

132270..135924 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001197956.2 → NP_001184885.1 cyclic nucleotide gated channel 10 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001184885.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LKL3, Q9LNJ0

UniProtKB/TrEMBL

A0A178W8D7, A0A5S9S075

Conserved Domains (2) summary

PLN03192
Location:46 → 491

PLN03192; Voltage-dependent potassium channel; Provisional

cd00038
Location:473 → 604

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_100016.3 → NP_563625.1 cyclic nucleotide gated channel 10 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_563625.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LNJ0

Conserved Domains (4) summary

COG0664
Location:462 → 597

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:468 → 599

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:118 → 397

Ion_trans; Ion transport protein

cl18962
Location:415 → 498

Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...