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NADK2 NAD kinase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838766, updated on 18-Sep-2024

Summary

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Official Symbol
NADK2
Official Full Name
NAD kinase 2
Primary source
TAIR:AT1G21640
Locus tag
AT1G21640
See related
Araport:AT1G21640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATNADK2; F8K7.5; F8K7_5; NAD kinase 2; NAD KINASE 2
Summary
Encodes a protein with NAD kinase activity. The protein was also shown to bind calmodulin.
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Genomic context

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See NADK2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
8
Sequence:
Chromosome: 1; NC_003070.9 (7588414..7592890)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene pumilio 20 Neighboring gene Calcium-binding EF hand family protein Neighboring gene Preprotein translocase SecA family protein Neighboring gene zinc ion binding protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metabolic changes associated with dark-induced leaf senescence in Arabidopsis nadk2 mutants. Chaomurilege, et al. Plant Signal Behav, 2023 Dec 31. PMID 37272565, Free PMC Article
  2. Chloroplast NAD kinase is essential for energy transduction through the xanthophyll cycle in photosynthesis. Takahashi H, et al. Plant Cell Physiol, 2006 Dec. PMID 17082216
  3. NADK2, an Arabidopsis chloroplastic NAD kinase, plays a vital role in both chlorophyll synthesis and chloroplast protection. Chai MF, et al. Plant Mol Biol, 2005 Nov. PMID 16244906
  4. Cloning and characterization of two NAD kinases from Arabidopsis. identification of a calmodulin binding isoform. Turner WL, et al. Plant Physiol, 2004 Jul. PMID 15247403, Free PMC Article
  5. Subcellular and tissue localization of NAD kinases from Arabidopsis: compartmentalization of de novo NADP biosynthesis. Waller JC, et al. Planta, 2010 Jan. PMID 19921251

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Metabolic changes associated with dark-induced leaf senescence in Arabidopsis nadk2 mutants.
    Title: Metabolic changes associated with dark-induced leaf senescence in Arabidopsis nadk2 mutants.
  2. The subcellular distribution of the three NADK isoforms was examined using NADK-green fluorescent protein (GFP) fusion proteins expressed transiently in Arabidopsis suspension-cultured cells.
    Title: Subcellular and tissue localization of NAD kinases from Arabidopsis: compartmentalization of de novo NADP biosynthesis.
  3. results suggest that NADK2 may be a chloroplast NAD kinase and play a vital role in chlorophyll synthesis and chloroplast protection against oxidative damage
    Title: NADK2, an Arabidopsis chloroplastic NAD kinase, plays a vital role in both chlorophyll synthesis and chloroplast protection.
  4. These results indicate that chloroplast NAD kinase (nadk2 gene), catalyzing phosphorylation of NAD, is essential for the proper photosynthetic machinery of PSII and the xanthophyll cycle.
    Title: Chloroplast NAD kinase is essential for energy transduction through the xanthophyll cycle in photosynthesis.
Submit: New GeneRIF Correction

General gene information

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NM_102013.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables NAD+ kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in NAD metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NADP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
NAD kinase 2
NP_001185057.1
  • NAD kinase 2 (NADK2); FUNCTIONS IN: NAD+ kinase activity, calmodulin binding; INVOLVED IN: pyridine nucleotide biosynthetic process, metabolic process; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATP-NAD kinase, PpnK-type, alpha/beta (InterPro:IPR017438), ATP-NAD kinase, PpnK-type (InterPro:IPR016064), ATP-NAD/AcoX kinase (InterPro:IPR002504), ATP-NAD kinase, PpnK-type, all-beta (InterPro:IPR017437); BEST Arabidopsis thaliana protein match is: NAD kinase 1 (TAIR:AT3G21070.2).
NP_564145.1
  • NAD kinase 2 (NADK2); FUNCTIONS IN: NAD+ kinase activity, calmodulin binding; INVOLVED IN: pyridine nucleotide biosynthetic process, metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATP-NAD kinase, PpnK-type, alpha/beta (InterPro:IPR017438), ATP-NAD kinase, PpnK-type (InterPro:IPR016064), ATP-NAD/AcoX kinase (InterPro:IPR002504), ATP-NAD kinase, PpnK-type, all-beta (InterPro:IPR017437); BEST Arabidopsis thaliana protein match is: NAD kinase 1 (TAIR:AT3G21070.2); Has 8697 Blast hits to 8591 proteins in 2758 species: Archae - 277; Bacteria - 5531; Metazoa - 247; Fungi - 416; Plants - 137; Viruses - 0; Other Eukaryotes - 2089 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    7588414..7592890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198128.1 → NP_001185057.1  NAD kinase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185057.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WBY1, A0A5S9VG96, F4HY34
    Conserved Domains (2) summary
    PLN02727
    Location:13 → 999
    PLN02727; NAD kinase
    cl01255
    Location:665 → 998
    DAGK_cat; Diacylglycerol kinase catalytic domain

  2. NM_102013.5 → NP_564145.1  NAD kinase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_564145.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9C5W3, Q9XI15
    UniProtKB/TrEMBL
    A0A178WBY1, A0A5S9VG96
    Conserved Domains (2) summary
    PLN02727
    Location:13 → 985
    PLN02727; NAD kinase
    cl01255
    Location:665 → 984
    DAGK_cat; Diacylglycerol kinase catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C5W3.1

Gene LinkOut

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