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Crot carnitine O-octanoyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 83842, updated on 2-Nov-2024

Summary

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Official Symbol
Crotprovided by RGD
Official Full Name
carnitine O-octanoyltransferaseprovided by RGD
Primary source
RGD:70908
See related
EnsemblRapid:ENSRNOG00000006779 AllianceGenome:RGD:70908
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables carnitine O-octanoyltransferase activity. Involved in response to xenobiotic stimulus. Located in peroxisome. Orthologous to human CROT (carnitine O-octanoyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 573.1), Kidney (RPKM 269.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Crot in Genome Data Viewer
Location:
4q12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (26031729..26088057)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (25068270..25133111)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (22079837..22116265)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3, subunit K, pseudogene 1 Neighboring gene uncharacterized LOC134486666 Neighboring gene uncharacterized protein C11orf98 homolog Neighboring gene uncharacterized LOC120102221 Neighboring gene ATP binding cassette subfamily B member 4 Neighboring gene uncharacterized LOC120102222 Neighboring gene ATP-binding cassette, sub-family B member 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and sequence analysis of the rat liver carnitine octanoyltransferase cDNA, its natural gene and the gene promoter. Choi SJ, et al. Biochim Biophys Acta, 1995 Nov 7. PMID 7495866
  2. Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver. Miyazawa S, et al. J Biochem, 1983 Aug. PMID 6630173
  3. Cloning, sequencing, and regulation of rat liver carnitine octanoyltransferase: transcriptional stimulation of the enzyme during peroxisome proliferation. Chatterjee B, et al. Biochemistry, 1988 Dec 13. PMID 3233218
  4. Changes in carnitine octanoyltransferase activity induce alteration in fatty acid metabolism. Le Borgne F, et al. Biochem Biophys Res Commun, 2011 Jun 17. PMID 21619872
  5. Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity. Jogl G, et al. J Biol Chem, 2005 Jan 7. PMID 15492013

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. model of malonyl coA binding site by mutational analysis
    Title: Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine O-octanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carnitine O-octanoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carnitine O-octanoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine O-octanoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables carnitine O-octanoyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in carnitine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carnitine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in carnitine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in coenzyme A metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in coenzyme A metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in coenzyme A metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in generation of precursor metabolites and energy IEA
Inferred from Electronic Annotation
more info
  
involved_in generation of precursor metabolites and energy ISO
Inferred from Sequence Orthology
more info
  
involved_in generation of precursor metabolites and energy ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in long-chain fatty acid transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in medium-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in medium-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in medium-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in medium-chain fatty acid transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisomal carnitine O-octanoyltransferase
Names
COT
NP_114193.2
XP_006236066.1
XP_006236067.1
XP_038964382.2
XP_038964386.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031987.2 → NP_114193.2  peroxisomal carnitine O-octanoyltransferase

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P11466, P48033
    UniProtKB/TrEMBL
    A6K232, F7F5D0, Q6GMN6
    Related
    ENSRNOP00000073847.3, ENSRNOT00000091799.3
    Conserved Domains (1) summary
    pfam00755
    Location:20 → 603
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    26031729..26088057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108454.2 → XP_038964382.2  peroxisomal carnitine O-octanoyltransferase isoform X2

    UniProtKB/TrEMBL
    A6K232, F7F5D0, Q6GMN6

  2. XM_039108458.2 → XP_038964386.1  peroxisomal carnitine O-octanoyltransferase isoform X2

    UniProtKB/Swiss-Prot
    P11466, P48033
    UniProtKB/TrEMBL
    A6K232, F7F5D0, Q6GMN6
    Conserved Domains (1) summary
    pfam00755
    Location:20 → 603
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

  3. XM_006236004.5 → XP_006236066.1  peroxisomal carnitine O-octanoyltransferase isoform X1

    UniProtKB/Swiss-Prot
    P11466, P48033
    Related
    ENSRNOP00000071087.3, ENSRNOT00000090968.3
    Conserved Domains (1) summary
    pfam00755
    Location:73 → 656
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

  4. XM_006236005.5 → XP_006236067.1  peroxisomal carnitine O-octanoyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006236067.1

    UniProtKB/Swiss-Prot
    P11466, P48033
    UniProtKB/TrEMBL
    A6K232, F7F5D0, Q6GMN6
    Conserved Domains (1) summary
    pfam00755
    Location:20 → 603
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11466.3 GenPept UniProtKB/Swiss-Prot:P11466

Gene LinkOut

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