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HCF173 high chlorophyll fluorescence phenotype 173 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 838243, updated on 18-Sep-2024

Summary

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Official Symbol
HCF173
Official Full Name
high chlorophyll fluorescence phenotype 173
Primary source
TAIR:AT1G16720
Locus tag
AT1G16720
See related
Araport:AT1G16720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F19K19.14; high chlorophyll fluorescence phenotype 173
Summary
Encodes HCF173, a protein with weak similarities to the superfamily of the short-chain dehydrogenases/reductases. HCF173 is involved in the initiation of translation of the psbA mRNA. Mutants shows a high chlorophyll fluorescence phenotype (hcf) and are severely affected in the accumulation of PSII subunits. The protein HCF173 is localized in the chloroplast, where it is mainly associated with the membrane system and is part of a higher molecular weight complex with psbA mRNA as a component of this complex.
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Genomic context

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See HCF173 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Sequence:
Chromosome: 1; NC_003070.9 (5722891..5726478)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Alpha-helical ferredoxin Neighboring gene p300/CBP acetyltransferase-related protein-like protein Neighboring gene histone acetyltransferase of the CBP family 12 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein L20 Neighboring gene uncharacterized protein Neighboring gene GPI-anchored adhesin-like protein, putative (Protein of unknown function, DUF547)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ribonucleoprotein Capture by in Vivo Expression of a Designer Pentatricopeptide Repeat Protein in Arabidopsis. McDermott JJ, et al. Plant Cell, 2019 Aug. PMID 31123048, Free PMC Article
  2. The nuclear-encoded factor HCF173 is involved in the initiation of translation of the psbA mRNA in Arabidopsis thaliana. Schult K, et al. Plant Cell, 2007 Apr. PMID 17435084, Free PMC Article
  3. LOW PHOTOSYNTHETIC EFFICIENCY 1 is required for light-regulated photosystem II biogenesis in Arabidopsis. Jin H, et al. Proc Natl Acad Sci U S A, 2018 Jun 26. PMID 29891689, Free PMC Article
  4. The atypical short-chain dehydrogenases HCF173 and HCF244 are jointly involved in translational initiation of the psbA mRNA of Arabidopsis. Link S, et al. Plant Physiol, 2012 Dec. PMID 23027666, Free PMC Article
  5. Regulation of transcription of nucleotide-binding leucine-rich repeat-encoding genes SNC1 and RPP4 via H3K4 trimethylation. Xia S, et al. Plant Physiol, 2013 Jul. PMID 23690534, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LPE1 interacts with a known regulator of psbA mRNA translation HIGH CHLOROPHYLL FLUORESCENCE 173 (HCF173) and facilitates the association of HCF173 with psbA mRNA.
    Title: LOW PHOTOSYNTHETIC EFFICIENCY 1 is required for light-regulated photosystem II biogenesis in Arabidopsis.
  2. HCF244 was identified by coexpression analysis of HCF173, which encodes a protein that is also necessary for psbA translational initiation and in addition for stabilization of this messenger RNA.
    Title: The atypical short-chain dehydrogenases HCF173 and HCF244 are jointly involved in translational initiation of the psbA mRNA of Arabidopsis.
  3. The protein HCF173 is localized in the chloroplast, where it is mainly associated with the membrane system. It is part of a higher molecular weight complex and is essential for translation of the D1 encoding psbA mRNA. [HCF173]
    Title: The nuclear-encoded factor HCF173 is involved in the initiation of translation of the psbA mRNA in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001332253.1
NM_001332254.1
NM_101533.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within photosystem II assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in photosystem II assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast envelope HDA PubMed 
located_in chloroplast membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast stroma HDA PubMed 
located_in chloroplast stroma IDA
Inferred from Direct Assay
more info
 PubMed 
located_in thylakoid membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
high chlorophyll fluorescence phenotype 173
NP_173116.1
  • high chlorophyll fluorescence phenotype 173 (HCF173); FUNCTIONS IN: binding, catalytic activity; INVOLVED IN: photosystem II assembly, translational initiation; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), NADH:ubiquinone oxidoreductase intermediate-associated protein 30 (InterPro:IPR013857), NmrA-like (InterPro:IPR008030); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT4G18810.2); Has 1950 Blast hits to 1792 proteins in 453 species: Archae - 27; Bacteria - 1263; Metazoa - 9; Fungi - 6; Plants - 464; Viruses - 0; Other Eukaryotes - 181 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    5722891..5726478
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_101533.4 → NP_173116.1  high chlorophyll fluorescence phenotype 173 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_173116.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8W4D6
    UniProtKB/TrEMBL
    A0A178WDD3, A0A5S9USS8
    Conserved Domains (2) summary
    cl21454
    Location:164 → 560
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    cl21728
    Location:285 → 420
    CIA30; Complex I intermediate-associated protein 30 (CIA30)

  2. NM_001332253.1 → NP_001323375.1  high chlorophyll fluorescence phenotype 173 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WDD3, A0A1P8AWU9, A0A5S9USS8

  3. NM_001332254.1 → NP_001323376.1  high chlorophyll fluorescence phenotype 173 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178WDD3, A0A1P8AWY1, A0A5S9USS8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8W4D6.1

Gene LinkOut

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