DET3 vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DET3
Official Full Name: vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3)
Primary source: TAIR:AT1G12840
Locus tag: AT1G12840
See related: Araport:AT1G12840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA VACUOLAR ATP SYNTHASE SUBUNIT C; ATVHA-C; DE-ETIOLATED 3; F13K23.9; F13K23_9; VACUOLAR ATP SYNTHASE SUBUNIT C
Summary: Encodes subunit C of the vacuolar H(+)-ATPase (V-ATPase). Bound and phosphorylated by AtWNK8.
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Genomic context

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See DET3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 11

Sequence:: Chromosome: 1; NC_003070.9 (4374205..4378514)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The A. thaliana mutants det3, pom-pom1, and eli1 were compared to determine if the shared mutant phenotype arose by perturbing a common regulatory mechanism.
Title: Comparison of lignin deposition in three ectopic lignification mutants.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_101154.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to proton-transporting ATPase activity, rotational mechanism	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within lignin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of carbohydrate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within unidimensional cell growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in extracellular region	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vacuolar membrane	HDA more info	PubMed
part_of vacuolar proton-transporting V-type ATPase, V1 domain	IDA Inferred from Direct Assay more info	PubMed
located_in vacuole	HDA more info	PubMed

General protein information

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Preferred Names: vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3)

NP_563916.1

DE-ETIOLATED 3 (DET3); FUNCTIONS IN: proton-transporting ATPase activity, rotational mechanism; INVOLVED IN: lignin biosynthetic process, regulation of carbohydrate biosynthetic process, unidimensional cell growth; LOCATED IN: in 6 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, V1 complex, subunit C (InterPro:IPR004907); Has 563 Blast hits to 541 proteins in 227 species: Archae - 0; Bacteria - 0; Metazoa - 263; Fungi - 140; Plants - 72; Viruses - 0; Other Eukaryotes - 88 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

4374205..4378514

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101154.4 → NP_563916.1 vacuolar ATP synthase subunit C (VATC) / V-ATPase C subunit / vacuolar proton pump C subunit (DET3) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_563916.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SDS7

UniProtKB/TrEMBL

A0A178WM16, A0A384KX64, C0SUV0

Conserved Domains (2) summary

cd14785
Location:57 → 77

V-ATPase_C; 3-helical coiled coil [structural motif]

pfam03223
Location:6 → 368

V-ATPase_C; V-ATPase subunit C