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Agxt2 alanine-glyoxylate aminotransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83784, updated on 18-Sep-2024

Summary

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Official Symbol
Agxt2provided by RGD
Official Full Name
alanine-glyoxylate aminotransferase 2provided by RGD
Primary source
RGD:621767
See related
EnsemblRapid:ENSRNOG00000017821 AllianceGenome:RGD:621767
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AGT2
Summary
Predicted to enable alanine-glyoxylate transaminase activity and beta-alanine-pyruvate transaminase activity. Predicted to be involved in carboxylic acid metabolic process and positive regulation of nitric oxide biosynthetic process. Predicted to be located in mitochondrion. Orthologous to human AGXT2 (alanine--glyoxylate aminotransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 3234.4) See more
Orthologs
human mouse all
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Genomic context

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See Agxt2 in Genome Data Viewer
Location:
2q16
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (61063416..61104828)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (59336252..59377664)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (60337667..60379144)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485719 Neighboring gene prolactin receptor Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene biogenesis of ribosomes BRX1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Distribution of D-3-aminoisobutyrate-pyruvate aminotransferase in the rat brain. Abe M, et al. BMC Neurosci, 2014 Apr 27. PMID 24766736, Free PMC Article
  2. Purification, characterization and inhibition of D-3-aminoisobutyrate aminotransferase from the rat liver. Tamaki N, et al. Eur J Biochem, 1990 Apr 20. PMID 2158891
  3. Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and β-aminoisobutyrate metabolism in healthy volunteers. Kittel A, et al. PLoS One, 2014. PMID 24586340, Free PMC Article
  4. Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production. Rodionov RN, et al. J Biol Chem, 2010 Feb 19. PMID 20018850, Free PMC Article
  5. Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver. Tamaki N, et al. Methods Enzymol, 2000. PMID 10989446

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of acute kidney injury by WGCNA.
    Title: Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of acute kidney injury by WGCNA.
  2. Our results suggest that D-AIB AT is distributed in the examined- just the regions and may play an important role there.
    Title: Distribution of D-3-aminoisobutyrate-pyruvate aminotransferase in the rat brain.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables (R)-3-amino-2-methylpropionate-pyruvate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (R)-3-amino-2-methylpropionate-pyruvate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables alanine-glyoxylate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alanine-glyoxylate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alanine-glyoxylate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables alanine-glyoxylate transaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables beta-alanine:pyruvate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-alanine:pyruvate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-alanine catabolic process, by transamination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-alanine catabolic process, by transamination ISO
Inferred from Sequence Orthology
more info
  
involved_in N(omega),N(omega)-dimethyl-L-arginine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycine biosynthetic process, by transamination of glyoxylate ISO
Inferred from Sequence Orthology
more info
  
involved_in glyoxylate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glyoxylate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
alanine--glyoxylate aminotransferase 2, mitochondrial
Names
(R)-3-amino-2-methylpropionate--pyruvate transaminase
AGT 2
D-3-aminoisobutyrate-pyruvate aminotransferase
D-AIBAT
D-beta-aminoisobutyrate-pyruvate aminotransferase
beta-ALAAT II
beta-alanine-pyruvate aminotransferase
NP_114023.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031835.2 → NP_114023.1  alanine--glyoxylate aminotransferase 2, mitochondrial

    See identical proteins and their annotated locations for NP_114023.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081765
    UniProtKB/Swiss-Prot
    O08616, Q642F1, Q64565
    UniProtKB/TrEMBL
    A6KJT6, A6KJT7
    Related
    ENSRNOP00000024035.5, ENSRNOT00000024035.9
    Conserved Domains (2) summary
    cd00610
    Location:65 → 503
    OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
    TIGR00707
    Location:79 → 503
    argD; transaminase, acetylornithine/succinylornithine family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    61063416..61104828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64565.2 GenPept UniProtKB/Swiss-Prot:Q64565

Gene LinkOut

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