OZS1 C4-dicarboxylate transporter/malic acid transport protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: OZS1
Gene description: C4-dicarboxylate transporter/malic acid transport protein
Primary source: Araport:AT1G12480
Locus tag: AT1G12480
See related: TAIR:AT1G12480
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CARBON DIOXIDE INSENSITIVE 3; CDI3; F5O11.23; F5O11_23; OZONE-SENSITIVE 1; RADICAL-INDUCED CELL DEATH 3; RCD3; SLAC1; SLOW ANION CHANNEL-ASSOCIATED 1
Summary: Encodes a membrane protein with 10 predicted transmembrane helices. SLAC1 is a multispanning membrane protein expressed predominantly in guard cells that plays a role in regulating cellular ion homeostasis and S-type anion currents. SLAC1 is important for normal stomatal closure in response to a variety of signals including elevated CO2, ozone, ABA, darkness, and humidity. SLAC1:GFP localizes to the plasma membrane.
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Genomic context

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See OZS1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 3

Sequence:: Chromosome: 1; NC_003070.9 (4257268..4259300, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
Title: Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model.
The CIPK23 protein kinase represses SLAC1-type anion channels in Arabidopsis guard cells and stimulates stomatal opening.
Title: The CIPK23 protein kinase represses SLAC1-type anion channels in Arabidopsis guard cells and stimulates stomatal opening.
Structure and activity of SLAC1 channels for stomatal signaling in leaves.
Title: Structure and activity of SLAC1 channels for stomatal signaling in leaves.
STRESS INDUCED FACTOR 2 Regulates Arabidopsis Stomatal Immunity through Phosphorylation of the Anion Channel SLAC1.
Title: STRESS INDUCED FACTOR 2 Regulates Arabidopsis Stomatal Immunity through Phosphorylation of the Anion Channel SLAC1.
SLAC1 activation by CPK6 or CBL5-CIPK11 was strictly dependent on dual lipid modification.
Title: N-myristoylation and S-acylation are common modifications of Ca(2+) -regulated Arabidopsis kinases and are required for activation of the SLAC1 anion channel.
Surveying in the locus, we extrapolated that the SLAC1 gene, which is associated with stomatal closure, was likely responsible for the difference of drought tolerance.
Title: Alteration of Arabidopsis SLAC1 promoter and its association with natural variation in drought tolerance.
SLAC1 is required for rapid stomatal closure in response to ozone, reduced air humidity and darkness.
Title: PYR/RCAR receptors contribute to ozone-, reduced air humidity-, darkness-, and CO2-induced stomatal regulation.
The predictive power of a systems dynamic model in Arabidopsis, is demonstrated to explain the paradoxical suppression of channels that facilitate K(+) uptake, slowing stomatal opening, by mutation of the SLAC1 anion channel.
Title: Systems dynamic modeling of a guard cell Cl- channel mutant uncovers an emergent homeostatic network regulating stomatal transpiration.
Guard cells with mutations in slac1 exhibit dramatically reduced inwardly-rectifying K+ channel currents. Decreasing the cytosolic Ca2+ concentration rapidly restores K+ channel currents in slac1 guard cells.
Title: Mutations in the SLAC1 anion channel slow stomatal opening and severely reduce K+ uptake channel activity via enhanced cytosolic [Ca2+] and increased Ca2+ sensitivity of K+ uptake channels.
Data suggest that SLAC1 may be a pathway providing CO(2) for photosynthesis in the guard cells.
Title: A possible CO2 conducting and concentrating mechanism in plant stomata SLAC1 channel.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_101120.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables monoatomic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic anion channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular monoatomic ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic anion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal-level water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stomatal closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of stomatal opening	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to carbon dioxide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to humidity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ozone	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stomatal closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stomatal movement	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C4-dicarboxylate transporter/malic acid transport protein

NP_563909.1

OZONE-SENSITIVE 1 (OZS1); CONTAINS InterPro DOMAIN/s: C4-dicarboxylate transporter/malic acid transport protein (InterPro:IPR004695); BEST Arabidopsis thaliana protein match is: SLAC1 homologue 3 (TAIR:AT5G24030.1); Has 903 Blast hits to 900 proteins in 365 species: Archae - 17; Bacteria - 650; Metazoa - 0; Fungi - 31; Plants - 165; Viruses - 0; Other Eukaryotes - 40 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

4257268..4259300 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101120.3 → NP_563909.1 C4-dicarboxylate transporter/malic acid transport protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_563909.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LD83

UniProtKB/TrEMBL

A0A178WLC1, A0A5S9U2E9, A0A654EA22

Conserved Domains (1) summary

cd09323
Location:187 → 493

TDT_SLAC1_like; Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1)