KEU Sec1/munc18-like (SM) proteins superfamily [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: KEU
Official Full Name: Sec1/munc18-like (SM) proteins superfamily
Primary source: TAIR:AT1G12360
Locus tag: AT1G12360
See related: Araport:AT1G12360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F5O11.8; F5O11_8; keule; SEC11
Summary: encodes a Sec1 protein and expressed throughout the plant. physically interacts with Syntaxin1 and is required for cytokinesis.
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Genomic context

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See KEU in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 21

Sequence:: Chromosome: 1; NC_003070.9 (4200864..4206486)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles of the Arabidopsis KEULE Gene in Postembryonic Development.
Title: Roles of the Arabidopsis KEULE Gene in Postembryonic Development.
R(20)R(21) motif represents a secondary site of interaction for the SEC11 protein during the transition of SYP121 from the occluded to the open conformation that leads to SNARE complex assembly.
Title: Dual Sites for SEC11 on the SNARE SYP121 Implicate a Binding Exchange during Secretory Traffic.
SEC1/Munc18 protein KEULE as a central regulatory node in the coordination of membrane and microtubule dynamics during plant cytokinesis
Title: The Membrane-Associated Sec1/Munc18 KEULE is Required for Phragmoplast Microtubule Reorganization During Cytokinesis in Arabidopsis.
The domain of SEC11 that bound the SYP121 N terminus was itself able to block secretory traffic in the wild type and syp122 but not in syp121 mutant Arabidopsis.
Title: Binding of SEC11 indicates its role in SNARE recycling after vesicle fusion and identifies two pathways for vesicular traffic to the plasma membrane.
results demonstrated that, like KEULE, SEC6 plays a physiological role in cytokinesis, and the SEC6-KEULE interaction may serve as a novel molecular linkage between arriving vesicles and membrane fusion
Title: Regulation of cytokinesis by exocyst subunit SEC6 and KEULE in Arabidopsis thaliana.
Data indicate that SEC11 (At1g12360) binds directly with SYP121 (At3g11820) both in vitro and in vivo to affect secretory traffic.
Title: Arabidopsis Sec1/Munc18 protein SEC11 is a competitive and dynamic modulator of SNARE binding and SYP121-dependent vesicle traffic.
KEULE interacted with an open conformation of KNOLLE that complemented both knolle and keule mutants
Title: Sec1/Munc18 protein stabilizes fusion-competent syntaxin for membrane fusion in Arabidopsis cytokinesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_101108.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cytokinesis by cell plate formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with endomembrane system	IDA Inferred from Direct Assay more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed

General protein information

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Preferred Names: Sec1/munc18-like (SM) proteins superfamily

NP_563905.1

keule (KEU); FUNCTIONS IN: protein transporter activity; INVOLVED IN: protein secretion, cytokinesis; LOCATED IN: cytosol, peripheral to membrane of membrane fraction, plasma membrane, vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Sec1-like protein (InterPro:IPR001619); BEST Arabidopsis thaliana protein match is: Sec1/munc18-like (SM) proteins superfamily (TAIR:AT4G12120.1); Has 1791 Blast hits to 1770 proteins in 229 species: Archae - 0; Bacteria - 0; Metazoa - 744; Fungi - 510; Plants - 223; Viruses - 0; Other Eukaryotes - 314 (source: NCBI BLink).