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cry5 cryptochrome circadian regulator 5 [ Danio rerio (zebrafish) ]

Gene ID: 83776, updated on 2-Nov-2024

Summary

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Official Symbol
cry5provided by ZNC
Official Full Name
cryptochrome circadian regulator 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-010426-8
See related
Ensembl:ENSDARG00000019498 AllianceGenome:ZFIN:ZDB-GENE-010426-8
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
z64phr; z6-4phr
Summary
Enables DNA (6-4) photolyase activity. Acts upstream of or within DNA repair and response to light stimulus. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; eye; integument; liver; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See cry5 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (39268518..39283812, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (39347031..39362391, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene DNA ligase 1 Neighboring gene FAD-dependent oxidoreductase domain containing 1 Neighboring gene decapping enzyme, scavenger Neighboring gene potassium inwardly rectifying channel subfamily J member 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Early embryonic light detection improves survival. Tamai TK, et al. Curr Biol, 2004 Feb 3. PMID 14986634
  2. Diphenyleneiodonium chloride, an inhibitor of reduced nicotinamide adenine dinucleotide phosphate oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish. Osaki T, et al. Biol Pharm Bull, 2011. PMID 21804230
  3. ERK Signaling Regulates Light-Induced Gene Expression via D-Box Enhancers in a Differential, Wavelength-Dependent Manner. Mracek P, et al. PLoS One, 2013. PMID 23840779, Free PMC Article
  4. Regulation of ddb2 expression in blind cavefish and zebrafish reveals plasticity in the control of sunlight-induced DNA damage repair. Zhao H, et al. PLoS Genet, 2021 Feb. PMID 33544716, Free PMC Article
  5. Clock genes rescue nphp mutations in zebrafish. Kayser N, et al. Hum Mol Genet, 2022 Dec 16. PMID 35861640, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA (6-4) photolyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyribodipyrimidine photo-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in entrainment of circadian clock by photoperiod IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to light stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cryptochrome circadian regulator 5
Names
6-4 photolyase
cry5/6-4phr
cryptochrome 5
cryptochrome circadian clock 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131788.1 → NP_571863.1  cryptochrome circadian regulator 5

    See identical proteins and their annotated locations for NP_571863.1

    Status: PROVISIONAL

    Source sequence(s)
    AB042254
    UniProtKB/TrEMBL
    Q9I911
    Related
    ENSDARP00000144318.1, ENSDART00000175136.2
    Conserved Domains (3) summary
    COG0415
    Location:5 → 486
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam00875
    Location:5 → 170
    DNA_photolyase; DNA photolyase
    pfam03441
    Location:213 → 485
    FAD_binding_7; FAD binding domain of DNA photolyase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    39268518..39283812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155405.4 → XP_005155462.1  cryptochrome circadian regulator 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B1I7, F1QHM9
    Related
    ENSDARP00000015621.5, ENSDART00000023831.6
    Conserved Domains (3) summary
    COG0415
    Location:5 → 486
    PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
    pfam00875
    Location:5 → 170
    DNA_photolyase; DNA photolyase
    pfam03441
    Location:213 → 485
    FAD_binding_7; FAD binding domain of DNA photolyase
Nucleotide Protein Strain
Heading Accession and Version

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