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RPS6KL1 ribosomal protein S6 kinase like 1 [ Homo sapiens (human) ]

Gene ID: 83694, updated on 3-Apr-2024

Summary

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Official Symbol
RPS6KL1provided by HGNC
Official Full Name
ribosomal protein S6 kinase like 1provided by HGNC
Primary source
HGNC:HGNC:20222
See related
Ensembl:ENSG00000198208 AllianceGenome:HGNC:20222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSKL2
Summary
Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in ribosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 4.6), testis (RPKM 3.0) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
14q24.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (74903951..74923260, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (69113051..69132361, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75370654..75389963, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene prospero homeobox 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75342793-75343292 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:75348551-75348777 Neighboring gene METTL5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8732 Neighboring gene HNF4 motif-containing MPRA enhancer 140 Neighboring gene dihydrolipoamide S-succinyltransferase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75388716-75389487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75389488-75390258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75401143-75401710 Neighboring gene uncharacterized LOC107984690 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5937 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5938 Neighboring gene placental growth factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8733 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:75431938-75433137 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75446625-75447250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75447251-75447876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75447877-75448500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75469302-75469982 Neighboring gene eukaryotic translation initiation factor 2B subunit beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The protein kinase complement of the human genome. Manning G, et al. Science, 2002 Dec 6. PMID 12471243
  2. The DNA sequence and analysis of human chromosome 14. Heilig R, et al. Nature, 2003 Feb 6. PMID 12508121
  3. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624, Free PMC Article
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  5. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identified as a pseudokinase and named RSKL2.
    Title: The protein kinase complement of the human genome.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35734, MGC11287

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal protein S6 kinase-like 1
NP_001357181.1
NP_001357182.1
NP_001357184.1
NP_001357185.1
NP_001357186.1
NP_001357187.1
NP_113652.2
XP_011535508.1
XP_011535509.1
XP_011535513.1
XP_011535515.1
XP_016877169.1
XP_016877171.1
XP_016877172.1
XP_016877173.1
XP_016877174.1
XP_016877175.1
XP_016877177.1
XP_016877180.1
XP_024305484.1
XP_024305485.1
XP_047287752.1
XP_047287753.1
XP_047287754.1
XP_047287755.1
XP_047287756.1
XP_047287757.1
XP_054232751.1
XP_054232752.1
XP_054232753.1
XP_054232754.1
XP_054232755.1
XP_054232756.1
XP_054232757.1
XP_054232758.1
XP_054232759.1
XP_054232760.1
XP_054232761.1
XP_054232762.1
XP_054232763.1
XP_054232764.1
XP_054232765.1
XP_054232766.1
XP_054232767.1
XP_054232768.1
XP_054232769.1
XP_054232770.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034007.1 RefSeqGene

    Range
    4183..23492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001370252.1 → NP_001357181.1  ribosomal protein S6 kinase-like 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC006530
    UniProtKB/TrEMBL
    B4DSP6
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148 → 508
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  2. NM_001370253.1 → NP_001357182.1  ribosomal protein S6 kinase-like 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC006530
    UniProtKB/TrEMBL
    B4DSP6
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:146 → 499
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  3. NM_001370255.1 → NP_001357184.1  ribosomal protein S6 kinase-like 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC006530
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:148 → 305
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001370256.1 → NP_001357185.1  ribosomal protein S6 kinase-like 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC006530
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:148 → 307
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001370257.1 → NP_001357186.1  ribosomal protein S6 kinase-like 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC006530
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:131 → 249
    PKc_like; Protein Kinases, catalytic domain

  6. NM_001370258.1 → NP_001357187.1  ribosomal protein S6 kinase-like 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC006530
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:131 → 219
    PKc_like; Protein Kinases, catalytic domain

  7. NM_031464.5 → NP_113652.2  ribosomal protein S6 kinase-like 1 isoform 2

    See identical proteins and their annotated locations for NP_113652.2

    Status: VALIDATED

    Source sequence(s)
    AC006530, AK299846
    Consensus CDS
    CCDS9834.2
    UniProtKB/Swiss-Prot
    A6NGM9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9, Q9Y6S9
    UniProtKB/TrEMBL
    B4DSP6
    Related
    ENSP00000450567.1, ENST00000557413.6
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148 → 539
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

RNA

  1. NR_163404.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006530

  2. NR_163405.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006530

  3. NR_163406.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC006530

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    74903951..74923260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431797.1 → XP_047287753.1  ribosomal protein S6 kinase-like 1 isoform X6

  2. XM_017021682.2 → XP_016877171.1  ribosomal protein S6 kinase-like 1 isoform X2

    UniProtKB/TrEMBL
    B4DSP6
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148 → 539
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  3. XM_047431796.1 → XP_047287752.1  ribosomal protein S6 kinase-like 1 isoform X2

  4. XM_024449717.2 → XP_024305485.1  ribosomal protein S6 kinase-like 1 isoform X2

    UniProtKB/TrEMBL
    B4DSP6
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148 → 539
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  5. XM_011537206.4 → XP_011535508.1  ribosomal protein S6 kinase-like 1 isoform X1

    See identical proteins and their annotated locations for XP_011535508.1

    UniProtKB/TrEMBL
    B4DSP6
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148 → 555
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  6. XM_011537213.4 → XP_011535515.1  ribosomal protein S6 kinase-like 1 isoform X7

    UniProtKB/TrEMBL
    B4DSP6
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:131 → 492
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  7. XM_017021691.3 → XP_016877180.1  ribosomal protein S6 kinase-like 1 isoform X14

  8. XM_047431800.1 → XP_047287756.1  ribosomal protein S6 kinase-like 1 isoform X12

  9. XM_011537211.4 → XP_011535513.1  ribosomal protein S6 kinase-like 1 isoform X6

    UniProtKB/TrEMBL
    B4DSP6
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:131 → 508
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  10. XM_047431801.1 → XP_047287757.1  ribosomal protein S6 kinase-like 1 isoform X13

  11. XM_024449716.2 → XP_024305484.1  ribosomal protein S6 kinase-like 1 isoform X2

    UniProtKB/TrEMBL
    B4DSP6
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148 → 539
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  12. XM_017021688.3 → XP_016877177.1  ribosomal protein S6 kinase-like 1 isoform X11

    Conserved Domains (3) summary
    smart00220
    Location:177 → 353
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:148 → 353
    PKc_like; Protein Kinases, catalytic domain

  13. XM_017021683.3 → XP_016877172.1  ribosomal protein S6 kinase-like 1 isoform X3

    UniProtKB/TrEMBL
    B4DSP6
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:148 → 525
    PKc_like; Protein Kinases, catalytic domain

  14. XM_017021684.3 → XP_016877173.1  ribosomal protein S6 kinase-like 1 isoform X4

    UniProtKB/TrEMBL
    B4DSP6
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148 → 523
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  15. XM_017021680.3 → XP_016877169.1  ribosomal protein S6 kinase-like 1 isoform X1

    UniProtKB/TrEMBL
    B4DSP6
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148 → 555
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  16. XM_011537207.3 → XP_011535509.1  ribosomal protein S6 kinase-like 1 isoform X1

    See identical proteins and their annotated locations for XP_011535509.1

    UniProtKB/TrEMBL
    B4DSP6
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148 → 555
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  17. XM_047431799.1 → XP_047287755.1  ribosomal protein S6 kinase-like 1 isoform X9

    Related
    ENSP00000450660.1, ENST00000555009.5

  18. XM_047431798.1 → XP_047287754.1  ribosomal protein S6 kinase-like 1 isoform X8

  19. XM_017021685.3 → XP_016877174.1  ribosomal protein S6 kinase-like 1 isoform X5

    UniProtKB/TrEMBL
    B4DSP6
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148 → 555
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  20. XM_017021686.3 → XP_016877175.1  ribosomal protein S6 kinase-like 1 isoform X10

    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cl21453
    Location:148 → 439
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    69113051..69132361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376787.1 → XP_054232762.1  ribosomal protein S6 kinase-like 1 isoform X6

  2. XM_054376781.1 → XP_054232756.1  ribosomal protein S6 kinase-like 1 isoform X2

  3. XM_054376782.1 → XP_054232757.1  ribosomal protein S6 kinase-like 1 isoform X2

  4. XM_054376780.1 → XP_054232755.1  ribosomal protein S6 kinase-like 1 isoform X2

  5. XM_054376778.1 → XP_054232753.1  ribosomal protein S6 kinase-like 1 isoform X1

  6. XM_054376788.1 → XP_054232763.1  ribosomal protein S6 kinase-like 1 isoform X7

  7. XM_054376795.1 → XP_054232770.1  ribosomal protein S6 kinase-like 1 isoform X14

  8. XM_054376793.1 → XP_054232768.1  ribosomal protein S6 kinase-like 1 isoform X12

  9. XM_054376786.1 → XP_054232761.1  ribosomal protein S6 kinase-like 1 isoform X6

  10. XM_054376794.1 → XP_054232769.1  ribosomal protein S6 kinase-like 1 isoform X13

  11. XM_054376779.1 → XP_054232754.1  ribosomal protein S6 kinase-like 1 isoform X2

  12. XM_054376792.1 → XP_054232767.1  ribosomal protein S6 kinase-like 1 isoform X11

  13. XM_054376783.1 → XP_054232758.1  ribosomal protein S6 kinase-like 1 isoform X3

  14. XM_054376784.1 → XP_054232759.1  ribosomal protein S6 kinase-like 1 isoform X4

  15. XM_054376776.1 → XP_054232751.1  ribosomal protein S6 kinase-like 1 isoform X1

  16. XM_054376777.1 → XP_054232752.1  ribosomal protein S6 kinase-like 1 isoform X1

  17. XM_054376790.1 → XP_054232765.1  ribosomal protein S6 kinase-like 1 isoform X9

  18. XM_054376789.1 → XP_054232764.1  ribosomal protein S6 kinase-like 1 isoform X8

  19. XM_054376785.1 → XP_054232760.1  ribosomal protein S6 kinase-like 1 isoform X5

  20. XM_054376791.1 → XP_054232766.1  ribosomal protein S6 kinase-like 1 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6S9.1 GenPept UniProtKB/Swiss-Prot:Q9Y6S9

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