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SLC35G5 solute carrier family 35 member G5 [ Homo sapiens (human) ]

Gene ID: 83650, updated on 11-Apr-2024

Summary

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Official Symbol
SLC35G5provided by HGNC
Official Full Name
solute carrier family 35 member G5provided by HGNC
Primary source
HGNC:HGNC:15546
See related
Ensembl:ENSG00000177710 MIM:615199; AllianceGenome:HGNC:15546
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMAC; AMAC1L2
Summary
This gene is intronless and probably arose from retrotransposition of a similar gene. It has high sequence similarity to the gene encoding acyl-malonyl condensing enzyme on chromosome 17. [provided by RefSeq, Aug 2011]
Orthologs
all
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Genomic context

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Location:
8p23.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (11331012..11332360)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (8406654..8408002, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (11188521..11189869)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene XK related 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18925 Neighboring gene ribosomal protein L17 pseudogene 29 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27002 Neighboring gene Sharpr-MPRA regulatory region 9232 Neighboring gene long intergenic non-protein coding RNA 529 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27004 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:11141809-11142310 Neighboring gene ribosomal protein L19 pseudogene 13 Neighboring gene myotubularin related protein 9 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:11204715-11205338 Neighboring gene FAM167A antisense RNA 1 Neighboring gene TDH antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 293, pseudogene Neighboring gene L-threonine dehydrogenase (pseudogene)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Emergence of primate genes by retrotransposon-mediated sequence transduction. Xing J, et al. Proc Natl Acad Sci U S A, 2006 Nov 21. PMID 17101974, Free PMC Article
  2. Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759. Appel S, et al. Eur J Hum Genet, 2002 Jan. PMID 11896452
  3. Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. Weissglas-Volkov D, et al. Circ Cardiovasc Genet, 2010 Feb. PMID 20160193, Free PMC Article
  4. Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. Park MH, et al. J Med Genet, 2011 Jan. PMID 20972250
  5. Common variants at 30 loci contribute to polygenic dyslipidemia. Kathiresan S, et al. Nat Genet, 2009 Jan. PMID 19060906, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population.
  3. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Common variants at 30 loci contribute to polygenic dyslipidemia.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 35 member G5
Names
acyl-malonyl condensing enzyme 1-like 2
acyl-malonyl-condensing enzyme 1-like protein 2
protein AMAC1L2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054028.2 → NP_473369.1  solute carrier family 35 member G5

    See identical proteins and their annotated locations for NP_473369.1

    Status: REVIEWED

    Source sequence(s)
    AF131216
    Consensus CDS
    CCDS5980.1
    UniProtKB/Swiss-Prot
    A2RRL6, Q96KT7
    Related
    ENSP00000371872.5, ENST00000382435.5
    Conserved Domains (1) summary
    COG0697
    Location:52 → 326
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    11331012..11332360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    2014485..2015833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    8406654..8408002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96KT7.1 GenPept UniProtKB/Swiss-Prot:Q96KT7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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