U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GLT1 NADH-dependent glutamate synthase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835427, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
GLT1
Official Full Name
NADH-dependent glutamate synthase 1
Primary source
TAIR:AT5G53460
Locus tag
AT5G53460
See related
Araport:AT5G53460
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MYN8.7; MYN8_7; NADH-dependent glutamate synthase 1; NADH-GOGAT
Summary
NADH-dependent glutamate synthase
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GLT1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
20
Sequence:
Chromosome: 5; NC_003076.8 (21700187..21710296)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene OBP3-responsive protein 1 Neighboring gene ncRNA Neighboring gene acyl-CoA binding protein 1 Neighboring gene ARM repeat superfamily protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Arabidopsis glt1-T mutant defines a role for NADH-GOGAT in the non-photorespiratory ammonium assimilatory pathway. Lancien M, et al. Plant J, 2002 Feb. PMID 11844111
  2. Use of Arabidopsis mutants and genes to study amide amino acid biosynthesis. Lam HM, et al. Plant Cell, 1995 Jul. PMID 7640525, Free PMC Article
  3. The Arabidopsis GTL1 transcription factor regulates water use efficiency and drought tolerance by modulating stomatal density via transrepression of SDD1. Yoo CY, et al. Plant Cell, 2010 Dec. PMID 21169508, Free PMC Article
  4. Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase. Van Leene J, et al. Nat Plants, 2019 Mar. PMID 30833711
  5. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help
NM_001203600.1
NM_001203601.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables glutamate synthase (NADH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate synthase (NADH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-glutamate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ammonia assimilation cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in developmental growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glutamate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutamate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nitrate assimilation TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in plastid HDA PubMed 
located_in plastid TAS
Traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
NADH-dependent glutamate synthase 1
NP_001190529.1
  • NADH-dependent glutamate synthase 1 (GLT1); CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Glutamine amidotransferase, class-II (InterPro:IPR000583), Aldolase-type TIM barrel (InterPro:IPR013785), Glutamate synthase, alpha subunit, C-terminal (InterPro:IPR002489), Adrenodoxin reductase (InterPro:IPR000759), Glutamate synthase, NADH/NADPH, small subunit 1 (InterPro:IPR006005), Fumarate reductase, C-terminal (InterPro:IPR012285), Glutamate synthase, central-N (InterPro:IPR006982), NAD(P)-binding domain (InterPro:IPR016040), Alpha-helical ferredoxin (InterPro:IPR009051), Glutamate synthase, eukaryotic (InterPro:IPR012220), Glutamate synthase, central-C (InterPro:IPR002932), Glutamine amidotransferase, type II (InterPro:IPR017932); BEST Arabidopsis thaliana protein match is: glutamate synthase 1 (TAIR:AT5G04140.1).
NP_001190530.1
  • NADH-dependent glutamate synthase 1 (GLT1); CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Glutamine amidotransferase, class-II (InterPro:IPR000583), Aldolase-type TIM barrel (InterPro:IPR013785), Glutamate synthase, alpha subunit, C-terminal (InterPro:IPR002489), Glutamate synthase, NADH/NADPH, small subunit 1 (InterPro:IPR006005), Adrenodoxin reductase (InterPro:IPR000759), Fumarate reductase, C-terminal (InterPro:IPR012285), Glutamate synthase, central-N (InterPro:IPR006982), NAD(P)-binding domain (InterPro:IPR016040), Glutamate synthase, eukaryotic (InterPro:IPR012220), Alpha-helical ferredoxin (InterPro:IPR009051), Glutamate synthase, central-C (InterPro:IPR002932), Glutamine amidotransferase, type II (InterPro:IPR017932); BEST Arabidopsis thaliana protein match is: glutamate synthase 1 (TAIR:AT5G04140.1).
NP_200158.2
  • NADH-dependent glutamate synthase 1 (GLT1); FUNCTIONS IN: glutamate synthase (NADH) activity; INVOLVED IN: nitrate assimilation, response to cadmium ion, glutamate biosynthetic process; LOCATED IN: chloroplast stroma, chloroplast, plastid; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Glutamine amidotransferase, class-II (InterPro:IPR000583), Glutamate synthase, alpha subunit, C-terminal (InterPro:IPR002489), Aldolase-type TIM barrel (InterPro:IPR013785), Adrenodoxin reductase (InterPro:IPR000759), Glutamate synthase, NADH/NADPH, small subunit 1 (InterPro:IPR006005), Fumarate reductase, C-terminal (InterPro:IPR012285), Glutamate synthase, central-N (InterPro:IPR006982), Glutamate synthase, eukaryotic (InterPro:IPR012220), NAD(P)-binding domain (InterPro:IPR016040), Alpha-helical ferredoxin (InterPro:IPR009051), Glutamate synthase, central-C (InterPro:IPR002932), Glutamine amidotransferase, type II (InterPro:IPR017932); BEST Arabidopsis thaliana protein match is: glutamate synthase 1 (TAIR:AT5G04140.1); Has 36461 Blast hits to 36289 proteins in 2576 species: Archae - 608; Bacteria - 18616; Metazoa - 663; Fungi - 406; Plants - 546; Viruses - 0; Other Eukaryotes - 15622 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    21700187..21710296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124725.5 → NP_200158.2  NADH-dependent glutamate synthase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200158.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WL27, Q56W62, Q8LPH2, Q9LV03
    UniProtKB/TrEMBL
    A0A5S9YDS4, A0A654GAI8
    Conserved Domains (8) summary
    PRK11750
    Location:106 → 1627
    gltB; glutamate synthase subunit alpha; Provisional
    PRK12810
    Location:1704 → 2186
    gltD; glutamate synthase subunit beta; Reviewed
    cd00982
    Location:1378 → 1627
    gltB_C; gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the ...
    cd02808
    Location:951 → 1332
    GltS_FMN; Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast ...
    pfam00310
    Location:117 → 544
    GATase_2; Glutamine amidotransferases class-II
    pfam04898
    Location:594 → 882
    Glu_syn_central; Glutamate synthase central domain
    pfam13450
    Location:1850 → 1884
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl19102
    Location:1741 → 1834
    Fer4_8; 4Fe-4S dicluster domain

  2. NM_001203601.1 → NP_001190530.1  NADH-dependent glutamate synthase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190530.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WL27, Q56W62, Q8LPH2, Q9LV03
    UniProtKB/TrEMBL
    A0A5S9YDS4, A0A654GAI8
    Conserved Domains (8) summary
    PRK11750
    Location:106 → 1627
    gltB; glutamate synthase subunit alpha; Provisional
    PRK12810
    Location:1704 → 2186
    gltD; glutamate synthase subunit beta; Reviewed
    cd00982
    Location:1378 → 1627
    gltB_C; gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the ...
    cd02808
    Location:951 → 1332
    GltS_FMN; Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast ...
    pfam00310
    Location:117 → 544
    GATase_2; Glutamine amidotransferases class-II
    pfam04898
    Location:594 → 882
    Glu_syn_central; Glutamate synthase central domain
    pfam13450
    Location:1850 → 1884
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl19102
    Location:1741 → 1834
    Fer4_8; 4Fe-4S dicluster domain

  3. NM_001203600.1 → NP_001190529.1  NADH-dependent glutamate synthase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190529.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WL27, Q56W62, Q8LPH2, Q9LV03
    UniProtKB/TrEMBL
    A0A5S9YDS4, A0A654GAI8
    Conserved Domains (8) summary
    PRK11750
    Location:106 → 1627
    gltB; glutamate synthase subunit alpha; Provisional
    PRK12810
    Location:1704 → 2186
    gltD; glutamate synthase subunit beta; Reviewed
    cd00982
    Location:1378 → 1627
    gltB_C; gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the ...
    cd02808
    Location:951 → 1332
    GltS_FMN; Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast ...
    pfam00310
    Location:117 → 544
    GATase_2; Glutamine amidotransferases class-II
    pfam04898
    Location:594 → 882
    Glu_syn_central; Glutamate synthase central domain
    pfam13450
    Location:1850 → 1884
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    cl19102
    Location:1741 → 1834
    Fer4_8; 4Fe-4S dicluster domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LV03.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools