CNGC1 cyclic nucleotide gated channel 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CNGC1
Official Full Name: cyclic nucleotide gated channel 1
Primary source: TAIR:AT5G53130
Locus tag: AT5G53130
See related: Araport:AT5G53130
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCNGC1; cyclic nucleotide gated channel 1; CYCLIC NUCLEOTIDE-GATED CHANNEL 1; MFH8.6; MFH8_6
Summary: member of Cyclic nucleotide gated channel family
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Genomic context

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See CNGC1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 8

Sequence:: Chromosome: 5; NC_003076.8 (21537721..21541029, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Channels formed (at least in part) by AtCNGC1 contribute (along with other channels) to Ca(2+) uptake into plants, and that Ca(2+) uptake into roots through AtCNGC1 affects some aspects of growth in the primary root of Arabidopsis seedlings.
Title: Characterization of plant phenotypes associated with loss-of-function of AtCNGC1, a plant cyclic nucleotide gated cation channel.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_124692.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calmodulin binding	TAS Traceable Author Statement more info	PubMed
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables inward rectifier potassium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within potassium ion transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclic nucleotide gated channel 1

NP_200125.1

cyclic nucleotide gated channel 1 (CNGC1); FUNCTIONS IN: inward rectifier potassium channel activity, cyclic nucleotide binding, intracellular cyclic nucleotide activated cation channel activity, calmodulin binding, cation channel activity; INVOLVED IN: potassium ion transport, calcium ion transport; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710); BEST Arabidopsis thaliana protein match is: cyclic nucleotide-gated channel 13 (TAIR:AT4G01010.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

21537721..21541029 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_124692.3 → NP_200125.1 cyclic nucleotide gated channel 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_200125.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O65717

UniProtKB/TrEMBL

A0A178UG34, A0A5S9YFV6, A0A654GAP0

Conserved Domains (2) summary

PLN03192
Location:78 → 557

PLN03192; Voltage-dependent potassium channel; Provisional

cd00038
Location:486 → 617

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...