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St3gal5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83505, updated on 2-Nov-2024

Summary

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Official Symbol
St3gal5provided by RGD
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 5provided by RGD
Primary source
RGD:620875
See related
EnsemblRapid:ENSRNOG00000010284 AllianceGenome:RGD:620875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siat9
Summary
Predicted to enable lactosylceramide alpha-2,3-sialyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in Golgi membrane. Human ortholog(s) of this gene implicated in salt and pepper syndrome. Orthologous to human ST3GAL5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Heart (RPKM 221.1), Spleen (RPKM 174.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See St3gal5 in Genome Data Viewer
Location:
4q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (105692840..105750774)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (104134613..104192558)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (99937499..99999905)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102169 Neighboring gene uncharacterized LOC102556495 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102546367 Neighboring gene uncharacterized LOC120102308 Neighboring gene atonal bHLH transcription factor 8 Neighboring gene surfactant protein B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase. Ishii A, et al. J Biol Chem, 1998 Nov 27. PMID 9822625
  2. Molecular cloning and functional expression of a fifth-type alpha 2,3-sialyltransferase (mST3Gal V: GM3 synthase). Kono M, et al. Biochem Biophys Res Commun, 1998 Dec 9. PMID 9875239
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lactosylceramide alpha-2,3-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lactosylceramide alpha-2,3-sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables lactosylceramide alpha-2,3-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables lactosylceramide alpha-2,3-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lactosylceramide alpha-2,3-sialyltransferase
Names
CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
GM3 synthase
ST3Gal V
ST3GalV
ganglioside GM3 synthase
sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase)
sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase)
NP_001385641.1
NP_001385642.1
NP_001385643.1
NP_112627.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398712.1 → NP_001385641.1  lactosylceramide alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2K3X7
    Related
    ENSRNOP00000072818.3, ENSRNOT00000078793.3
    Conserved Domains (1) summary
    pfam00777
    Location:142 → 409
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. NM_001398713.1 → NP_001385642.1  lactosylceramide alpha-2,3-sialyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    O88830, Q68G12
    UniProtKB/TrEMBL
    A6IA96
    Related
    ENSRNOP00000082302.1, ENSRNOT00000115948.2
    Conserved Domains (1) summary
    pfam00777
    Location:115 → 382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. NM_001398714.2 → NP_001385643.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    Conserved Domains (1) summary
    pfam00777
    Location:15 → 282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. NM_031337.3 → NP_112627.2  lactosylceramide alpha-2,3-sialyltransferase isoform 2

    See identical proteins and their annotated locations for NP_112627.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    O88830, Q68G12
    UniProtKB/TrEMBL
    A0A8I5ZTQ4, A6IA96
    Related
    ENSRNOP00000042426.1, ENSRNOT00000050249.4
    Conserved Domains (1) summary
    pfam00777
    Location:115 → 382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_174121.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    105692840..105750774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68G12.1 GenPept UniProtKB/Swiss-Prot:Q68G12

Gene LinkOut

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