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KAT5 peroxisomal 3-keto-acyl-CoA thiolase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834946, updated on 18-Sep-2024

Summary

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Official Symbol
KAT5
Official Full Name
peroxisomal 3-keto-acyl-CoA thiolase 2
Primary source
TAIR:AT5G48880
Locus tag
AT5G48880
See related
Araport:AT5G48880
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
3-KETO-ACYL-COA THIOLASE; 3-KETO-ACYL-COENZYME A THIOLASE 5; K24G6.22; K24G6_22; peroxisomal 3-keto-acyl-CoA thiolase 2; PEROXISOMAL 3-KETO-ACYL-COA THIOLASE 2; PEROXISOMAL-3-KETO-ACYL-COA THIOLASE 1; PKT1; PKT2
Summary
Encodes a peroxisomal 3-keto-acyl-CoA thiolase 2 precursor. EC2.3.1.16 thiolases. AT5G48880.1 is named PKT1 and AT5G48880.2 is named PKT2.
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Genomic context

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See KAT5 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
14
Sequence:
Chromosome: 5; NC_003076.8 (19814395..19817955, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene Small nuclear ribonucleoprotein family protein Neighboring gene C2H2-like zinc finger protein Neighboring gene Pectin lyase-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Peroxisomal plant 3-ketoacyl-CoA thiolase structure and activity are regulated by a sensitive redox switch. Pye VE, et al. J Biol Chem, 2010 Jul 30. PMID 20463027, Free PMC Article
  2. Knockout of the two evolutionarily conserved peroxisomal 3-ketoacyl-CoA thiolases in Arabidopsis recapitulates the abnormal inflorescence meristem 1 phenotype. Wiszniewski AA, et al. J Exp Bot, 2014 Dec. PMID 25297549, Free PMC Article
  3. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Peroxisomal KAT2 and KAT5 have partially redundant functions and operate downstream of AIM1 to provide beta-oxidation functions essential for inflorescence development and fertility.
    Title: Knockout of the two evolutionarily conserved peroxisomal 3-ketoacyl-CoA thiolases in Arabidopsis recapitulates the abnormal inflorescence meristem 1 phenotype.
  2. Peroxisomal plant 3-ketoacyl-CoA thiolase structure and activity are regulated by a sensitive redox swit
    Title: Peroxisomal plant 3-ketoacyl-CoA thiolase structure and activity are regulated by a sensitive redox switch.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_001036960.2
NM_001344808.1
NM_124265.5
NM_180826.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables acetyl-CoA C-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid oxidation TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in peroxisome HDA PubMed 

General protein information

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Preferred Names
peroxisomal 3-keto-acyl-CoA thiolase 2
NP_001032037.1
  • peroxisomal 3-keto-acyl-CoA thiolase 2; FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity, acetyl-CoA C-acyltransferase activity; INVOLVED IN: fatty acid oxidation; LOCATED IN: peroxisome; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, conserved site (InterPro:IPR020613), Thiolase, C-terminal (InterPro:IPR020617), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039), Thiolase, acyl-enzyme intermediate active site (InterPro:IPR020615); BEST Arabidopsis thaliana protein match is: peroxisomal 3-ketoacyl-CoA thiolase 3 (TAIR:AT2G33150.1); Has 22215 Blast hits to 22197 proteins in 2240 species: Archae - 413; Bacteria - 13972; Metazoa - 985; Fungi - 661; Plants - 288; Viruses - 0; Other Eukaryotes - 5896 (source: NCBI BLink).
NP_568704.2
  • peroxisomal 3-keto-acyl-CoA thiolase 2 (PKT2); FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity, acetyl-CoA C-acyltransferase activity; INVOLVED IN: fatty acid oxidation; LOCATED IN: peroxisome; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, conserved site (InterPro:IPR020613), Thiolase, C-terminal (InterPro:IPR020617), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039), Thiolase, acyl-enzyme intermediate active site (InterPro:IPR020615); BEST Arabidopsis thaliana protein match is: peroxisomal 3-ketoacyl-CoA thiolase 3 (TAIR:AT2G33150.1); Has 22215 Blast hits to 22197 proteins in 2240 species: Archae - 413; Bacteria - 13972; Metazoa - 985; Fungi - 661; Plants - 288; Viruses - 0; Other Eukaryotes - 5896 (source: NCBI BLink).
NP_851157.1
  • PEROXISOMAL-3-KETO-ACYL-COA THIOLASE 1 (PKT1); FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity, acetyl-CoA C-acyltransferase activity; INVOLVED IN: fatty acid oxidation; LOCATED IN: peroxisome; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase (InterPro:IPR002155), Thiolase, active site (InterPro:IPR020610), Thiolase, N-terminal (InterPro:IPR020616), Thiolase, conserved site (InterPro:IPR020613), Thiolase, C-terminal (InterPro:IPR020617), Thiolase-like, subgroup (InterPro:IPR016038), Thiolase-like (InterPro:IPR016039), Thiolase, acyl-enzyme intermediate active site (InterPro:IPR020615); BEST Arabidopsis thaliana protein match is: peroxisomal 3-ketoacyl-CoA thiolase 4 (TAIR:AT1G04710.1); Has 22254 Blast hits to 22236 proteins in 2248 species: Archae - 414; Bacteria - 14009; Metazoa - 985; Fungi - 662; Plants - 288; Viruses - 0; Other Eukaryotes - 5896 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    19814395..19817955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180826.4 → NP_851157.1  peroxisomal 3-keto-acyl-CoA thiolase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851157.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UD50, Q0WLJ0
    Conserved Domains (2) summary
    PLN02287
    Location:1 → 414
    PLN02287; 3-ketoacyl-CoA thiolase
    cd00751
    Location:9 → 396
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

  2. NM_124265.5 → NP_568704.2  peroxisomal 3-keto-acyl-CoA thiolase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568704.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O65339, Q570C8, Q9S774
    UniProtKB/TrEMBL
    A0A178UEC0, A0A5S9YCB1, A0A654G9U6
    Conserved Domains (1) summary
    PLN02287
    Location:1 → 457
    PLN02287; 3-ketoacyl-CoA thiolase

  3. NM_001036960.2 → NP_001032037.1  peroxisomal 3-keto-acyl-CoA thiolase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001032037.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O65339, Q570C8, Q9S774
    UniProtKB/TrEMBL
    A0A178UEC0, A0A5S9YCB1, A0A654G9U6
    Conserved Domains (1) summary
    PLN02287
    Location:1 → 457
    PLN02287; 3-ketoacyl-CoA thiolase

  4. NM_001344808.1 → NP_001331840.1  peroxisomal 3-keto-acyl-CoA thiolase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O65339, Q570C8, Q9S774
    UniProtKB/TrEMBL
    A0A178UEC0, A0A5S9YCB1, A0A654G9U6
    Conserved Domains (1) summary
    PLN02287
    Location:1 → 457
    PLN02287; 3-ketoacyl-CoA thiolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q570C8.2

Gene LinkOut

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