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RBOHD respiratory burst oxidase homologue D [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834842, updated on 14-Feb-2024

Summary

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Gene symbol
RBOHD
Gene description
respiratory burst oxidase homologue D
Primary source
Araport:AT5G47910
Locus tag
AT5G47910
See related
TAIR:AT5G47910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATRBOHD; MCA23.25; MCA23_25; RESPIRATORY BURST OXIDASE; respiratory burst oxidase homologue D
Summary
NADPH/respiratory burst oxidase protein D (RbohD).Interacts with AtrbohF gene to fine tune the spatial control of ROI production and hypersensitive response to cell in and around infection site.
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Genomic context

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See RBOHD in Genome Data Viewer
Location:
chromosome: 5
Exon count:
8
Sequence:
Chromosome: 5; NC_003076.8 (19397041..19402061)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene NADH-ubiquinone oxidoreductase B8 subunit Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase-like protein (DUF1624) Neighboring gene transcription elongation factor Neighboring gene Zinc-binding ribosomal protein family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The plant NADPH oxidase RBOHD is required for microbiota homeostasis in leaves. Pfeilmeier S, et al. Nat Microbiol, 2021 Jul. PMID 34194036, Free PMC Article
  2. Vascular Bundles Mediate Systemic Reactive Oxygen Signaling during Light Stress. Zandalinas SI, et al. Plant Cell, 2020 Nov. PMID 32938754, Free PMC Article
  3. Antepenultimate residue at the C-terminus of NADPH oxidase RBOHD is critical for its function in the production of reactive oxygen species in Arabidopsis. Li QY, et al. J Zhejiang Univ Sci B, 2019 Sept.. PMID 31379142, Free PMC Article
  4. Local and Systemic Metabolic Responses during Light-Induced Rapid Systemic Signaling. Choudhury FK, et al. Plant Physiol, 2018 Dec. PMID 30279198, Free PMC Article
  5. A stress recovery signaling network for enhanced flooding tolerance in Arabidopsis thaliana. Yeung E, et al. Proc Natl Acad Sci U S A, 2018 Jun 26. PMID 29891679, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The phagocytosis oxidase/Bem1p domain-containing protein PB1CP negatively regulates the NADPH oxidase RBOHD in plant immunity.
    Title: The phagocytosis oxidase/Bem1p domain-containing protein PB1CP negatively regulates the NADPH oxidase RBOHD in plant immunity.
  2. Spatial regulation of RBOHD via AtECA4-mediated recycling and clathrin-mediated endocytosis contributes to ROS accumulation during salt stress response but not flg22-induced immune response.
    Title: Spatial regulation of RBOHD via AtECA4-mediated recycling and clathrin-mediated endocytosis contributes to ROS accumulation during salt stress response but not flg22-induced immune response.
  3. FLS2-RBOHD-PIF4 Module Regulates Plant Response to Drought and Salt Stress.
    Title: FLS2-RBOHD-PIF4 Module Regulates Plant Response to Drought and Salt Stress.
  4. The plant NADPH oxidase RBOHD is required for microbiota homeostasis in leaves.
    Title: The plant NADPH oxidase RBOHD is required for microbiota homeostasis in leaves.
  5. Vascular Bundles Mediate Systemic Reactive Oxygen Signaling during Light Stress.
    Title: Vascular Bundles Mediate Systemic Reactive Oxygen Signaling during Light Stress.
  6. CRK2 and C-terminal Phosphorylation of NADPH Oxidase RBOHD Regulate Reactive Oxygen Species Production in Arabidopsis.
    Title: CRK2 and C-terminal Phosphorylation of NADPH Oxidase RBOHD Regulate Reactive Oxygen Species Production in Arabidopsis.
  7. Persulfidation-based Modification of Cysteine Desulfhydrase and the NADPH Oxidase RBOHD Controls Guard Cell Abscisic Acid Signaling.
    Title: Persulfidation-based Modification of Cysteine Desulfhydrase and the NADPH Oxidase RBOHD Controls Guard Cell Abscisic Acid Signaling.
  8. Decrease of Arabidopsis PAO activity entails increased RBOH activity, ROS content and altered responses to Pseudomonas.
    Title: Decrease of Arabidopsis PAO activity entails increased RBOH activity, ROS content and altered responses to Pseudomonas.
  9. residue E919 is indispensable for RBOHD function in the microbe-associated molecular pattern-induced reactive oxygen species burst and stomatal closure
    Title: Antepenultimate residue at the C-terminus of NADPH oxidase RBOHD is critical for its function in the production of reactive oxygen species in Arabidopsis.
  10. data suggest that AtrbohD functions downstream of ROP2 to positively regulate the response to waterlogging stress in Arabidopsis.
    Title: AtrbohD functions downstream of ROP2 and positively regulates waterlogging response in Arabidopsis.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_124165.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables NAD(P)H oxidase H2O2-forming activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables NAD(P)H oxidase H2O2-forming activity TAS
Traceable Author Statement
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
acts_upstream_of_or_within defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within osmosensory signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within reactive oxygen species metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within reactive oxygen species metabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane HDA PubMed 
located_in plastid HDA PubMed 

General protein information

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Preferred Names
respiratory burst oxidase homologue D
NP_199602.1
  • respiratory burst oxidase homologue D (RBOHD); FUNCTIONS IN: NAD(P)H oxidase activity; INVOLVED IN: oxygen and reactive oxygen species metabolic process, defense response to fungus, response to heat, defense response, negative regulation of programmed cell death; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Cytochrome b245, heavy chain (InterPro:IPR000778), EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-hand-like domain (InterPro:IPR011992), Ferric reductase-like transmembrane component, N-terminal (InterPro:IPR013130), NADPH oxidase Respiratory burst (InterPro:IPR013623), Ferric reductase, NAD binding (InterPro:IPR013121), EF-HAND 2 (InterPro:IPR018249), FAD-binding 8 (InterPro:IPR013112), Riboflavin synthase-like beta-barrel (InterPro:IPR017938); BEST Arabidopsis thaliana protein match is: NADPH/respiratory burst oxidase protein D (TAIR:AT5G51060.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    19397041..19402061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124165.3 → NP_199602.1  respiratory burst oxidase homologue D [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199602.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81212, Q9FIJ0
    UniProtKB/TrEMBL
    A0A178U7Y0
    Conserved Domains (5) summary
    cd06186
    Location:619 → 921
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd00051
    Location:237 → 283
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:424 → 571
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam08030
    Location:736 → 903
    NAD_binding_6; Ferric reductase NAD binding domain
    pfam08414
    Location:161 → 255
    NADPH_Ox; Respiratory burst NADPH oxidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FIJ0.1

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