CDCA3 cell division cycle associated 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDCA3provided by HGNC
Official Full Name: cell division cycle associated 3provided by HGNC
Primary source: HGNC:HGNC:14624
See related: Ensembl:ENSG00000111665 MIM:607749; AllianceGenome:HGNC:14624
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GRCC8; TOME1; TOME-1
Summary: Predicted to be involved in cell division and protein ubiquitination. Located in adherens junction. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis (RPKM 6.4), duodenum (RPKM 3.8) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p13.31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (6844798..6851286, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (6854092..6860585, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (6953962..6960450, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of circ_0038632 as a Promoter of Breast Cancer through miR-520a-3p-Dependent Modulation of CDCA3.
Title: Identification of circ_0038632 as a Promoter of Breast Cancer through miR-520a-3p-Dependent Modulation of CDCA3.
MiRNA-144-5p down-modulates CDCA3 to regulate proliferation and apoptosis of lung adenocarcinoma cells.
Title: MiRNA-144-5p down-modulates CDCA3 to regulate proliferation and apoptosis of lung adenocarcinoma cells.
CDCA3 exhibits a role in promoting the progression of ovarian cancer.
Title: CDCA3 exhibits a role in promoting the progression of ovarian cancer.
MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3.
Title: MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3.
LncCDCA3L inhibits cell proliferation via a novel RNA structure-based crosstalk with CDCA3 in hepatocellular carcinoma.
Title: LncCDCA3L inhibits cell proliferation via a novel RNA structure-based crosstalk with CDCA3 in hepatocellular carcinoma.
Prognostic value of CDCA3 in kidney renal papillary cell carcinoma.
Title: Prognostic value of CDCA3 in kidney renal papillary cell carcinoma.
Suppression of CDCA3 inhibits prostate cancer progression via NFkappaB/cyclin D1 signaling inactivation and p21 accumulation.
Title: Suppression of CDCA3 inhibits prostate cancer progression via NF‑κB/cyclin D1 signaling inactivation and p21 accumulation.
Circ_0001421 facilitates glycolysis and lung cancer development by regulating miR-4677-3p/CDCA3.
Title: Circ_0001421 facilitates glycolysis and lung cancer development by regulating miR-4677-3p/CDCA3.
Circular RNA hsa_circ_101555 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-145-5p and regulating CDCA3 expression.
Title: Circular RNA hsa_circ_101555 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-145-5p and regulating CDCA3 expression.
Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy.
Title: Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell division cycle-associated protein 3

Names: gene-rich cluster protein C8; trigger of mitotic entry protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001297602.3 → NP_001284531.1 cell division cycle-associated protein 3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

U47924

Consensus CDS

CCDS76512.1

UniProtKB/TrEMBL

B2R749, J3KMY0

Related

ENSP00000229265.5, ENST00000229265.10

Conserved Domains (1) summary

PHA03247
Location:2 → 156

PHA03247; large tegument protein UL36; Provisional
NM_001297603.3 → NP_001284532.1 cell division cycle-associated protein 3 isoform 3

See identical proteins and their annotated locations for NP_001284532.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' structure, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (3) has a distinct C-terminus, and is shorter, compared to isoform 1.

Source sequence(s)

AK092246, AK291421, U47924

Consensus CDS

CCDS76513.1

UniProtKB/TrEMBL

F8WDL1

Related

ENSP00000415142.2, ENST00000422785.7
NM_001297604.3 → NP_001284533.1 cell division cycle-associated protein 3 isoform 4

See identical proteins and their annotated locations for NP_001284533.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (4) has a distinct C-terminus, and is shorter, compared to isoform 1.

Source sequence(s)

AK291421, BQ961607, U47924

Consensus CDS

CCDS73428.1

UniProtKB/TrEMBL

F5GX58

Related

ENSP00000441120.1, ENST00000540683.1
NM_001331019.2 → NP_001317948.1 cell division cycle-associated protein 3 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the both the 5' and 3' coding regions and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus and distict, shorter C-terminus compared to isoform 1.

Source sequence(s)

AK291421, AV714087, U47924

UniProtKB/Swiss-Prot

Q99618
NM_031299.7 → NP_112589.1 cell division cycle-associated protein 3 isoform 1

See identical proteins and their annotated locations for NP_112589.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK291421, U47924

Consensus CDS

CCDS8565.1

UniProtKB/Swiss-Prot

A8K5V6, D3DUS6, Q99618

UniProtKB/TrEMBL

B2R749

Related

ENSP00000442068.1, ENST00000538862.7

RNA

NR_123727.3 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK291421, DA735127, U47924
NR_138531.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks an exon in the 5' region and uses an alternate splice site in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 6, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

U47924