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CYP707A3 cytochrome P450, family 707, subfamily A, polypeptide 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834570, updated on 18-Sep-2024

Summary

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Official Symbol
CYP707A3
Official Full Name
cytochrome P450, family 707, subfamily A, polypeptide 3
Primary source
TAIR:AT5G45340
Locus tag
AT5G45340
See related
Araport:AT5G45340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
''cytochrome P450; cytochrome P450; family 707; K9E15.12; K9E15_12; polypeptide 3; polypeptide 3''; subfamily A
Summary
Encodes a protein with ABA 8'-hydroxylase activity; involved in ABA catabolism. Mutant analyses show that disruption in the gene results in more drought tolerance whereas overexpression results in increased transpiration rate and reduced drought tolerance. Gene involved in postgermination growth. Plant P450 CYP707A3, ABA 8'-hydroxylase, binds enantioselectively (+)-ABA but not (-)-ABA, whereas the enzyme binds both enantiomers of AHI1 (a structural ABA analogue used as ABA 8'-hydroxylase competitive inhibitor).
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Genomic context

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See CYP707A3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
5
Sequence:
Chromosome: 5; NC_003076.8 (18368532..18371021, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene late embryogenesis abundant protein Neighboring gene decapping 5-like protein Neighboring gene proline-rich family protein Neighboring gene F-box family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CYP707A3, a major ABA 8'-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana. Umezawa T, et al. Plant J, 2006 Apr. PMID 16623881
  2. High humidity induces abscisic acid 8'-hydroxylase in stomata and vasculature to regulate local and systemic abscisic acid responses in Arabidopsis. Okamoto M, et al. Plant Physiol, 2009 Feb. PMID 19036833, Free PMC Article
  3. Arabidopsis CYP707As encode (+)-abscisic acid 8'-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid. Saito S, et al. Plant Physiol, 2004 Apr. PMID 15064374, Free PMC Article
  4. Regulation of hormone metabolism in Arabidopsis seeds: phytochrome regulation of abscisic acid metabolism and abscisic acid regulation of gibberellin metabolism. Seo M, et al. Plant J, 2006 Nov. PMID 17010113
  5. Integrative Analysis from the Epigenome to Translatome Uncovers Patterns of Dominant Nuclear Regulation during Transient Stress. Lee TA, et al. Plant Cell, 2019 Nov. PMID 31519798, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CYP707A3 reduces the amount of mobile abscisic acid in vacular tissues in response to high humidity in Arabidopsis.
    Title: High humidity induces abscisic acid 8'-hydroxylase in stomata and vasculature to regulate local and systemic abscisic acid responses in Arabidopsis.
  2. Determins threshold levels of abscisic acid during dehydration and after rehydration.
    Title: CYP707A3, a major ABA 8'-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_123902.3
NM_180805.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables (+)-abscisic acid 8'-hydroxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within abscisic acid catabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
acts_upstream_of_or_within response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to red or far red light IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in extracellular region ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
cytochrome P450, family 707, subfamily A, polypeptide 3
NP_199347.2
  • ''cytochrome P450, family 707, subfamily A, polypeptide 3'' (CYP707A3); FUNCTIONS IN: oxygen binding, (+)-abscisic acid 8'-hydroxylase activity; INVOLVED IN: in 8 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 707, subfamily A, polypeptide 1 (TAIR:AT4G19230.2); Has 36434 Blast hits to 36316 proteins in 1856 species: Archae - 82; Bacteria - 8479; Metazoa - 11318; Fungi - 6149; Plants - 8238; Viruses - 6; Other Eukaryotes - 2162 (source: NCBI BLink).
NP_851136.1
  • ''cytochrome P450, family 707, subfamily A, polypeptide 3'' (CYP707A3); FUNCTIONS IN: oxygen binding, (+)-abscisic acid 8'-hydroxylase activity; INVOLVED IN: in 8 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 707, subfamily A, polypeptide 1 (TAIR:AT4G19230.1); Has 36672 Blast hits to 36553 proteins in 1858 species: Archae - 82; Bacteria - 8489; Metazoa - 11350; Fungi - 6268; Plants - 8323; Viruses - 6; Other Eukaryotes - 2154 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    18368532..18371021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_180805.4 → NP_851136.1  cytochrome P450, family 707, subfamily A, polypeptide 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_851136.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3E8G7, Q9FH76
    UniProtKB/TrEMBL
    A0A178UJX7, A0A5S9YCB8
    Conserved Domains (1) summary
    PLN02196
    Location:1 → 463
    PLN02196; abscisic acid 8'-hydroxylase

  2. NM_123902.3 → NP_199347.2  cytochrome P450, family 707, subfamily A, polypeptide 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199347.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UJX7, A0A5S9YCB8
    Conserved Domains (1) summary
    PLN02196
    Location:1 → 446
    PLN02196; abscisic acid 8'-hydroxylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FH76.1

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