Trem2 triggering receptor expressed on myeloid cells 2 [ Mus musculus (house mouse) ]

Gene ID: 83433, updated on 17-Nov-2024

Summary

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Official Symbol: Trem2provided by MGI
Official Full Name: triggering receptor expressed on myeloid cells 2provided by MGI
Primary source: MGI:MGI:1913150
See related: Ensembl:ENSMUSG00000023992 AllianceGenome:MGI:1913150
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TREM-2; Trem2a; Trem2b; Trem2c
Summary: The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 19.6), ovary adult (RPKM 10.2) and 20 other tissues See more
Orthologs: human all
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Genomic context

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See Trem2 in Genome Data Viewer

Location:: 17 C; 17 23.99 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (48653429..48659304)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (48346401..48352276)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of TREM2 on BV2 inflammation through PI3K/AKT/mTOR pathway.
Title: Regulation of TREM2 on BV2 inflammation through PI3K/AKT/mTOR pathway.
Targeting TREM2 signaling shows limited impact on cerebrovascular calcification.
Title: Targeting TREM2 signaling shows limited impact on cerebrovascular calcification.
Distinct roles of TREM2 in central nervous system cancers and peripheral cancers.
Title: Distinct roles of TREM2 in central nervous system cancers and peripheral cancers.
Clusterin from endometrial glands plays a critical role in decidualization via Trem2.
Title: Clusterin from endometrial glands plays a critical role in decidualization via Trem2.
Trem2 acts as a non-classical receptor of interleukin-4 to promote diabetic wound healing.
Title: Trem2 acts as a non-classical receptor of interleukin-4 to promote diabetic wound healing.
Mechanism of the effect of TREM2 on cognitive function in autistic mice.
Title: Mechanism of the effect of TREM2 on cognitive function in autistic mice.
Intermittent hypoxia training enhances Abeta endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease.
Title: Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease.
Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2.
Title: Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2.
Trem2-deficiency aggravates and accelerates age-related myelin degeneration.
Title: Trem2-deficiency aggravates and accelerates age-related myelin degeneration.
TREM2-dependent activation of microglial cell protects photoreceptor cell during retinal degeneration via PPARgamma and CD36.
Title: TREM2-dependent activation of microglial cell protects photoreceptor cell during retinal degeneration via PPARγ and CD36.

Submit: New GeneRIF Correction See all GeneRIFs (243)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (29) 1 citation
Spontaneous (1)
Targeted (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables apolipoprotein A-I binding	IEA Inferred from Electronic Annotation more info
enables apolipoprotein A-I binding	ISO Inferred from Sequence Orthology more info
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle binding	IEA Inferred from Electronic Annotation more info
enables high-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables kinase activator activity	ISO Inferred from Sequence Orthology more info
enables kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables lipoteichoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables low-density lipoprotein particle binding	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables peptidoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylethanolamine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylethanolamine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables semaphorin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables semaphorin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables sulfatide binding	ISO Inferred from Sequence Orthology more info
enables sulfatide binding	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables very-low-density lipoprotein particle binding	IEA Inferred from Electronic Annotation more info
enables very-low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within_positive_effect CXCL12-activated CXCR4 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect CXCL12-activated CXCR4 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IDA Inferred from Direct Assay more info	PubMed
involved_in amyloid-beta clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid-beta clearance by cellular catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid-beta clearance by cellular catabolic process	ISO Inferred from Sequence Orthology more info
involved_in amyloid-beta clearance by cellular catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in astrocyte activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to amyloid-beta	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipoteichoic acid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidised low-density lipoprotein particle stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidised low-density lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to peptidoglycan	IDA Inferred from Direct Assay more info	PubMed
involved_in complement-mediated synapse pruning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of lipoteichoic acid	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of peptidoglycan	IDA Inferred from Direct Assay more info	PubMed
involved_in excitatory synapse pruning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in import into cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in innate immune response	IC Inferred by Curator more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipopolysaccharide-mediated signaling pathway	IC Inferred by Curator more info	PubMed
involved_in memory	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect memory	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microglial cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microglial cell activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microglial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of NLRP3 inflammasome complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid fibril formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of astrocyte activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of autophagic cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of autophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cholesterol storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fat cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macrophage colony-stimulating factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage colony-stimulating factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuroinflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuroinflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sequestering of triglyceride	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of toll-like receptor 2 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of toll-like receptor 4 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroinflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoclast differentiation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis, engulfment	IDA Inferred from Direct Assay more info	PubMed
involved_in phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis, recognition	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis, recognition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of C-C chemokine receptor CCR7 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of C-C chemokine receptor CCR7 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CAMKK-AMPK signaling cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of CD40 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of CD40 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TOR signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of amyloid-beta clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of antigen processing and presentation of peptide antigen via MHC class II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of antigen processing and presentation of peptide antigen via MHC class II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cholesterol efflux	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of complement activation, classical pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of engulfment of apoptotic cell	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of engulfment of apoptotic cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of high-density lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inward rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of low-density lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microglial cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of microglial cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of microglial cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microglial cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of microglial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microglial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microglial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuroinflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis, engulfment	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis, engulfment	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse pruning	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse pruning	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_negative_effect pyroptotic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hippocampal neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of intracellular signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of macrophage inflammatory protein 1 alpha production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of peptidyl-tyrosine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of plasma membrane bounded cell projection organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of plasma membrane bounded cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of plasma membrane bounded cell projection organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of resting membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of toll-like receptor 6 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in respiratory burst after phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to axon injury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to axon injury	ISO Inferred from Sequence Orthology more info
involved_in response to ischemia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semaphorin-plexin signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_positive_effect social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect social behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane raft	IEA Inferred from Electronic Annotation more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: triggering receptor expressed on myeloid cells 2

Names: triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2a; triggering receptor expressed on myeloid cells 2b; triggering receptor expressed on myeloid cells 2c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.