TGG1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TGG1
Primary source: Araport:AT5G26000
Locus tag: AT5G26000
See related: TAIR:AT5G26000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtTGG1; BETA GLUCOSIDASE 38; BGLU38; THIOGLUCOSIDE GLUCOHYDROLASE; thioglucoside glucohydrolase 1
Summary: member of Glycoside Hydrolase Family 1. encodes one of two known functional myrosinase enzymes in Arabidopsis. The enzyme catalyzes the hydrolysis of glucosinolates into compounds that are toxic to various microbes and herbivores.
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Genomic context

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Location:: chromosome: 5

Exon count:: 12

Sequence:: Chromosome: 5; NC_003076.8 (9079452..9082384, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Jasmonate regulates the FAMA/mediator complex subunit 8-THIOGLUCOSIDE GLUCOHYDROLASE 1 cascade and myrosinase activity.
Title: Jasmonate regulates the FAMA/mediator complex subunit 8-THIOGLUCOSIDE GLUCOHYDROLASE 1 cascade and myrosinase activity.
The Imaging of Guard Cells of thioglucosidase (tgg) Mutants of Arabidopsis Further Links Plant Chemical Defence Systems with Physical Defence Barriers.
Title: The Imaging of Guard Cells of thioglucosidase (tgg) Mutants of Arabidopsis Further Links Plant Chemical Defence Systems with Physical Defence Barriers.
The Myrosinases TGG1 and TGG2 Function Redundantly in Reactive Carbonyl Species Signaling in Arabidopsis Guard Cells.
Title: The Myrosinases TGG1 and TGG2 Function Redundantly in Reactive Carbonyl Species Signaling in Arabidopsis Guard Cells.
The tgg1, single and tgg1 tgg2 double mutants showed morphological changes compared to wild-type plants visible as changes in pavement cells, stomatal cells and the ultrastructure of the cuticle.
Title: Arabidopsis myrosinases link the glucosinolate-myrosinase system and the cuticle.
Data indicate that loss of the basic helix-loop-helix transcription factor FAMA function abolishes myrosin idioblasts (MIs) fate as well as the expression of the myrosinase genes TGG1 and TGG2.
Title: Myrosin idioblast cell fate and development are regulated by the Arabidopsis transcription factor FAMA, the auxin pathway, and vesicular trafficking.
These results demonstrate that TGG1 and TGG2 have the ability to function in environments like the digestive tract of insect herbivores that are significantly different from the environment in a damaged plant.
Title: Properties of β-thioglucoside hydrolases (TGG1 and TGG2) from leaves of Arabidopsis thaliana.
TGG1 and TGG2 function redundantly downstream of ROS production and upstream of cytosolic Ca2+ elevation in abscisic acid and methyl jasmonate signaling in guard cells.
Title: Myrosinases, TGG1 and TGG2, redundantly function in ABA and MeJA signaling in Arabidopsis guard cells.
TGG1 showed striking abundance in the guard cell and tgg1 mutants were hyposensitive to abscisic acid inhibition of guard cell inward K(+) channels and stomatal opening, revealing TGG1 is required for key ABA responses of guard cells.
Title: Functional proteomics of Arabidopsis thaliana guard cells uncovers new stomatal signaling pathways.
The molecular bases underlying differences of the glucosinolate-myrosinase system in suspension cells and hypocotyls are reported.
Title: Comparative investigations of the glucosinolate-myrosinase system in Arabidopsis suspension cells and hypocotyls.
Arabidopsis myrosinases TGG1 and TGG2 are functionally redundant.
Title: Arabidopsis myrosinases TGG1 and TGG2 have redundant function in glucosinolate breakdown and insect defense.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_122501.3

Supported by ESTs:

NM_180746.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables beta-glucosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucosinolate glucohydrolase activity	IEA Inferred from Electronic Annotation more info
enables scopolin beta-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables thioglucosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables thioglucosidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables thioglucosidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in defense response to insect	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucosinolate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucosinolate catabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of stomatal movement	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to insect	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in cytosolic ribosome	HDA more info	PubMed
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in peroxisome	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plastid	HDA more info	PubMed
located_in secretory vesicle	HDA more info	PubMed
located_in thylakoid	HDA more info	PubMed

General protein information

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Preferred Names: thioglucoside glucohydrolase 1

NP_197972.2

thioglucoside glucohydrolase 1 (TGG1); FUNCTIONS IN: thioglucosidase activity, beta-glucosidase activity, hydrolase activity, hydrolyzing O-glycosyl compounds; INVOLVED IN: glucosinolate catabolic process; LOCATED IN: in 7 components; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 1 (InterPro:IPR001360), Glycoside hydrolase, family 1, active site (InterPro:IPR018120), Glycoside hydrolase, catalytic core (InterPro:IPR017853), Glycoside hydrolase, subgroup, catalytic core (InterPro:IPR013781); BEST Arabidopsis thaliana protein match is: glucoside glucohydrolase 2 (TAIR:AT5G25980.2); Has 10598 Blast hits to 10348 proteins in 1443 species: Archae - 123; Bacteria - 7528; Metazoa - 688; Fungi - 189; Plants - 1364; Viruses - 0; Other Eukaryotes - 706 (source: NCBI BLink).

NP_851077.1

thioglucoside glucohydrolase 1 (TGG1); FUNCTIONS IN: thioglucosidase activity, beta-glucosidase activity, hydrolase activity, hydrolyzing O-glycosyl compounds; INVOLVED IN: glucosinolate catabolic process; LOCATED IN: in 7 components; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 1 (InterPro:IPR001360), Glycoside hydrolase, family 1, active site (InterPro:IPR018120), Glycoside hydrolase, catalytic core (InterPro:IPR017853), Glycoside hydrolase, subgroup, catalytic core (InterPro:IPR013781); BEST Arabidopsis thaliana protein match is: glucoside glucohydrolase 2 (TAIR:AT5G25980.2); Has 11138 Blast hits to 10810 proteins in 1458 species: Archae - 132; Bacteria - 7708; Metazoa - 712; Fungi - 191; Plants - 1422; Viruses - 0; Other Eukaryotes - 973 (source: NCBI BLink).