U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FZD8 frizzled class receptor 8 [ Homo sapiens (human) ]

Gene ID: 8325, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
FZD8provided by HGNC
Official Full Name
frizzled class receptor 8provided by HGNC
Primary source
HGNC:HGNC:4046
See related
Ensembl:ENSG00000177283 MIM:606146; AllianceGenome:HGNC:4046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FZ-8; hFZ8
Summary
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See FZD8 in Genome Data Viewer
Location:
10p11.21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (35638247..35642296, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (35668401..35672451, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35927175..35931224, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984221 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:35883203-35883845 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:35889926-35890176 Neighboring gene gap junction protein delta 4 Neighboring gene VISTA enhancer hs1588 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:35927732-35928593 Neighboring gene Sharpr-MPRA regulatory region 6098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3269 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2308 Neighboring gene zinc finger protein 469-like Neighboring gene uncharacterized LOC105376494 Neighboring gene microRNA 4683 Neighboring gene uncharacterized LOC124902411 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:35952948-35953138

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Molecular model of the Wnt protein binding site on the surface of dimeric CRD domain of the hFzd8 receptor. Voronkov AE, et al. Dokl Biochem Biophys, 2008 Mar-Apr. PMID 18505162
  2. A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis. Spanjer AI, et al. Thorax, 2016 Apr. PMID 26797711
  3. Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2. Saitoh T, et al. Int J Oncol, 2001 May. PMID 11295046
  4. Wnt receptor Frizzled 8 is a target of ERG in prostate cancer. Chakravarthi BVSK, et al. Prostate, 2018 Dec. PMID 30051493
  5. MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8. Xu L, et al. Oncotarget, 2016 Jun 28. PMID 27276676, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis.
    Title: CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis.
  2. Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.
    Title: Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.
  3. MiR-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting FZD8.
    Title: MiR-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting FZD8.
  4. Frizzled-4 is required for normal bone acquisition despite compensation by Frizzled-8.
    Title: Frizzled-4 is required for normal bone acquisition despite compensation by Frizzled-8.
  5. FZD8 Indicates a Poor Prognosis and Promotes Gastric Cancer Invasion and Metastasis via B-Catenin Signaling Pathway.
    Title: FZD8 Indicates a Poor Prognosis and Promotes Gastric Cancer Invasion and Metastasis via B-Catenin Signaling Pathway.
  6. Expression of FZD8 is directly correlated with ERG expression in prostate cancer. Furthermore, we show that ERG directly targets and activates FZD8 by binding to its promoter. This activation is specific to ETS transcription factor ERG and not ETV1.
    Title: Wnt receptor Frizzled 8 is a target of ERG in prostate cancer.
  7. FZD8 forms a TGF-beta-regulated complex with TGF-beta receptors that is mediated by the extracellular domains of FZD8 and TGFBR1
    Title: Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer.
  8. miR-375 functions as a tumor-suppressive microRNA by directly acting upon FZD8, which may serve as a new therapeutic target to inhibit tumor metastasis in colorectal cancer
    Title: MicroRNA-375 suppresses human colorectal cancer metastasis by targeting Frizzled 8.
  9. Elevated expression of TP53 target FZD8 promoted prostate cancer bone metastasis by activating the canonical Wnt/beta-catenin signaling pathway.
    Title: FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt/β-catenin signaling.
  10. these findings suggest that miR-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/b-catenin signaling pathway and manipulation of miR-100 may provide a promoting therapeutic strategy for cancer breast treatment.
    Title: MicroRNA-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/β-catenin signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
EBI GWAS Catalog
Genetically distinct subsets within ANCA-associated vasculitis.
EBI GWAS Catalog
Genome-wide association study of periodontal pathogen colonization.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables Wnt receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Wnt receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
  
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of Wnt-Frizzled-LRP5/6 complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in neuronal dense core vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
frizzled-8
Names
frizzled 8, seven transmembrane spanning receptor
frizzled family receptor 8
frizzled homolog 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029968.1 RefSeqGene

    Range
    4139..8188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_031866.3 → NP_114072.1  frizzled-8 precursor

    See identical proteins and their annotated locations for NP_114072.1

    Status: REVIEWED

    Source sequence(s)
    AL121749
    Consensus CDS
    CCDS7192.1
    UniProtKB/Swiss-Prot
    Q9H461
    Related
    ENSP00000363826.1, ENST00000374694.3
    Conserved Domains (2) summary
    cd07461
    Location:31 → 155
    CRD_FZ8; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 8 (Fz8) receptor
    cd15250
    Location:267 → 618
    7tmF_FZD8; class F frizzled subfamily 8, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    35638247..35642296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    35668401..35672451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H461.1 GenPept UniProtKB/Swiss-Prot:Q9H461

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous