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SLAH3 SLAC1 homologue 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832468, updated on 18-Sep-2024

Summary

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Official Symbol
SLAH3
Official Full Name
SLAC1 homologue 3
Primary source
TAIR:AT5G24030
Locus tag
AT5G24030
See related
Araport:AT5G24030
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MZF18.9; MZF18_9; SLAC1 homologue 3
Summary
Encodes a protein with ten predicted transmembrane helices. The SLAH3 protein has similarity to the SLAC1 protein involved in ion homeostasis in guard cells. Although it is not expressed in guard cells, it can complement an slac1-2 mutant suggesting that it performs a similar function. SLAH3:GFP localizes to the plasma membrane.
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Genomic context

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See SLAH3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Sequence:
Chromosome: 5; NC_003076.8 (8118317..8122914, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene septum site-determining protein (MIND) Neighboring gene F-box SKIP23-like protein (DUF295) Neighboring gene plant-specific B3-DNA-binding domain protein (DUF313)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Acidosis-induced activation of anion channel SLAH3 in the flooding-related stress response of Arabidopsis. Lehmann J, et al. Curr Biol, 2021 Aug 23. PMID 34233161
  2. Anion channel SLAH3 functions in nitrate-dependent alleviation of ammonium toxicity in Arabidopsis. Zheng X, et al. Plant Cell Environ, 2015 Mar. PMID 24944085
  3. Kinase SnRK1.1 regulates nitrate channel SLAH3 engaged in nitrate-dependent alleviation of ammonium toxicity. Sun D, et al. Plant Physiol, 2021 May 27. PMID 33560419, Free PMC Article
  4. Anion channel SLAH3 is a regulatory target of chitin receptor-associated kinase PBL27 in microbial stomatal closure. Liu Y, et al. Elife, 2019 Sep 16. PMID 31524595, Free PMC Article
  5. Silent S-Type Anion Channel Subunit SLAH1 Gates SLAH3 Open for Chloride Root-to-Shoot Translocation. Cubero-Font P, et al. Curr Biol, 2016 Aug 22. PMID 27397895

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Acidosis-induced activation of anion channel SLAH3 in the flooding-related stress response of Arabidopsis.
    Title: Acidosis-induced activation of anion channel SLAH3 in the flooding-related stress response of Arabidopsis.
  2. Kinase SnRK1.1 regulates nitrate channel SLAH3 engaged in nitrate-dependent alleviation of ammonium toxicity.
    Title: Kinase SnRK1.1 regulates nitrate channel SLAH3 engaged in nitrate-dependent alleviation of ammonium toxicity.
  3. Here, the authors show that stomatal closure to fungal chitin is conferred by the major PRRs for chitin recognition, LYK5 and CERK1, the receptor-like cytoplasmic kinase PBL27, and the SLAH3 anion channel. PBL27 has the capacity to phosphorylate SLAH3, of which S127 and S189 are required to activate SLAH3.
    Title: Anion channel SLAH3 is a regulatory target of chitin receptor-associated kinase PBL27 in microbial stomatal closure.
  4. The AtSLAH1 gene is expressed in the root xylem-pole pericycle, where it co-localizes with AtSLAH3. Under high soil salinity, AtSLAH1 expression markedly declined and the chloride content of the xylem sap in AtSLAH1 loss-of-function mutants was half of the wild-type level only. S
    Title: Silent S-Type Anion Channel Subunit SLAH1 Gates SLAH3 Open for Chloride Root-to-Shoot Translocation.
  5. SLAH3, a nitrate efflux channel, plays a role in nitrate-dependent alleviation of ammonium toxicity in plants.
    Title: Anion channel SLAH3 functions in nitrate-dependent alleviation of ammonium toxicity in Arabidopsis.
  6. Pollen tube growth regulation by free anions depends on the interaction between the anion channel SLAH3 and calcium-dependent protein kinases CPK2 and CPK20.
    Title: Pollen tube growth regulation by free anions depends on the interaction between the anion channel SLAH3 and calcium-dependent protein kinases CPK2 and CPK20.
  7. the anion channel SLAH3 is regulated by the ABA signaling pathway
    Title: Arabidopsis nanodomain-delimited ABA signaling pathway regulates the anion channel SLAH3.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001343836.1
NM_122308.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables voltage-gated monoatomic anion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated monoatomic anion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chloride transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular monoatomic ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular monoatomic ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
SLAC1 homologue 3
NP_197791.1
  • SLAC1 homologue 3 (SLAH3); FUNCTIONS IN: transporter activity; INVOLVED IN: cellular ion homeostasis; LOCATED IN: integral to membrane, plasma membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: C4-dicarboxylate transporter/malic acid transport protein (InterPro:IPR004695); BEST Arabidopsis thaliana protein match is: SLAC1 homologue 2 (TAIR:AT4G27970.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    8118317..8122914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_122308.5 → NP_197791.1  SLAC1 homologue 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197791.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FLV9
    UniProtKB/TrEMBL
    A0A178USC2, A0A5S9Y795
    Conserved Domains (1) summary
    cd09323
    Location:257 → 560
    TDT_SLAC1_like; Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1)

  2. NM_001343836.1 → NP_001332637.1  SLAC1 homologue 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1R7T388
    Conserved Domains (1) summary
    cd09323
    Location:257 → 507
    TDT_SLAC1_like; Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FLV9.1

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