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PAA2 uncharacterized protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 832253, updated on 18-Sep-2024

Summary

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Official Symbol
PAA2
Official Full Name
uncharacterized protein
Primary source
TAIR:AT5G21930
Locus tag
AT5G21930
See related
Araport:AT5G21930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS HEAVY METAL ATPASE 8; ATHMA8; HEAVY METAL ATPASE 8; HMA8; P-type ATPase of Arabidopsis 2
Summary
P-Type ATPase, mediates copper transport to chloroplast thylakoid lumen. Required for accumulation of copper-containing plastocyanin in the thylakoid lumen and for effective photosynthetic electron transport
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Genomic context

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See PAA2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
17
Sequence:
Chromosome: 5; NC_003076.8 (7243002..7249170)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RNI-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene YGGT family protein Neighboring gene hybrid signal transduction histidine kinase M-like protein Neighboring gene miscRNA Neighboring gene alpha/beta-Hydrolases superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural Insights into the Nucleotide-Binding Domains of the P1B-type ATPases HMA6 and HMA8 from Arabidopsis thaliana. Mayerhofer H, et al. PLoS One, 2016. PMID 27802305, Free PMC Article
  2. Identification of Two Conserved Residues Involved in Copper Release from Chloroplast PIB-1-ATPases. Sautron E, et al. J Biol Chem, 2016 Sep 16. PMID 27493208, Free PMC Article
  3. HMA6 and HMA8 are two chloroplast Cu+-ATPases with different enzymatic properties. Sautron E, et al. Biosci Rep, 2015 Apr 20. PMID 26182363, Free PMC Article
  4. Two P-type ATPases are required for copper delivery in Arabidopsis thaliana chloroplasts. Abdel-Ghany SE, et al. Plant Cell, 2005 Apr. PMID 15772282, Free PMC Article
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The crystal structures of the nucleotide binding domain of HMA6 and HMA8 from Arabidopsis thaliana are reported at 1.5A and 1.75A resolution, respectively, providing the first structural information on plants Cu+-ATPases.
    Title: Structural Insights into the Nucleotide-Binding Domains of the P1B-type ATPases HMA6 and HMA8 from Arabidopsis thaliana.
  2. Combining functional and structural data, we highlight the importance of the cysteine and the first histidine of the CX3HX2H motif in the process of copper release from HMA6 and HMA8 and propose a copper pathway through the membrane domain of these transporters.
    Title: Identification of Two Conserved Residues Involved in Copper Release from Chloroplast PIB-1-ATPases.
  3. HMA8 is transiently phosphorylated from ATP. HMA8 enzymatic properties and affinity for Cu
    Title: HMA6 and HMA8 are two chloroplast Cu+-ATPases with different enzymatic properties.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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NM_001036843.1
NM_001203428.1
NM_001343706.1
NM_147876.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type divalent copper transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables copper ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within copper ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photosynthetic electron transport chain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast thylakoid membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
NP_001031920.1
  • P-type ATPase of Arabidopsis 2 (PAA2); CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121), ATPase, P type, cation/copper-transporter (InterPro:IPR006403), ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type, heavy metal translocating (InterPro:IPR006416), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: P-type ATP-ase 1 (TAIR:AT4G33520.2); Has 37090 Blast hits to 31889 proteins in 3147 species: Archae - 785; Bacteria - 23835; Metazoa - 3811; Fungi - 2543; Plants - 1791; Viruses - 5; Other Eukaryotes - 4320 (source: NCBI BLink).
NP_001190357.1
  • P-type ATPase of Arabidopsis 2 (PAA2); CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121), ATPase, P type, cation/copper-transporter (InterPro:IPR006403), ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type, heavy metal translocating (InterPro:IPR006416), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: P-type ATP-ase 1 (TAIR:AT4G33520.2).
NP_001331520.1
  • P-type ATPase of Arabidopsis 2
NP_680181.2
  • P-type ATPase of Arabidopsis 2 (PAA2); CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121), ATPase, P type, cation/copper-transporter (InterPro:IPR006403), ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type, heavy metal translocating (InterPro:IPR006416), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: P-type ATP-ase 1 (TAIR:AT4G33520.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    7243002..7249170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001203428.1 → NP_001190357.1  uncharacterized protein AT5G21930 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190357.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2FG72, F4K8C8
    Conserved Domains (4) summary
    COG2217
    Location:80 → 848
    ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
    COG4087
    Location:658 → 776
    COG4087; Soluble P-type ATPase [General function prediction only]
    cd00371
    Location:80 → 146
    HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
    pfam00122
    Location:285 → 514
    E1-E2_ATPase; E1-E2 ATPase

  2. NM_001343706.1 → NP_001331520.1  uncharacterized protein AT5G21930 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BE56, A0A7G2FG72

  3. NM_147876.5 → NP_680181.2  uncharacterized protein AT5G21930 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_680181.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DFX7, Q7Y051, Q9C594
    UniProtKB/TrEMBL
    A0A7G2FG72
    Conserved Domains (4) summary
    COG2217
    Location:80 → 871
    ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
    COG4087
    Location:681 → 799
    COG4087; Soluble P-type ATPase [General function prediction only]
    cd00371
    Location:80 → 146
    HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
    pfam00122
    Location:285 → 537
    E1-E2_ATPase; E1-E2 ATPase

  4. NM_001036843.1 → NP_001031920.1  uncharacterized protein AT5G21930 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031920.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DFX7, Q7Y051, Q9C594
    UniProtKB/TrEMBL
    A0A7G2FG72
    Conserved Domains (4) summary
    COG2217
    Location:80 → 871
    ZntA; Cation transport ATPase [Inorganic ion transport and metabolism]
    COG4087
    Location:681 → 799
    COG4087; Soluble P-type ATPase [General function prediction only]
    cd00371
    Location:80 → 146
    HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...
    pfam00122
    Location:285 → 537
    E1-E2_ATPase; E1-E2 ATPase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B9DFX7.1

Gene LinkOut

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