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CDC45 cell division cycle 45 [ Homo sapiens (human) ]

Gene ID: 8318, updated on 3-Apr-2024

Summary

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Official Symbol
CDC45provided by HGNC
Official Full Name
cell division cycle 45provided by HGNC
Primary source
HGNC:HGNC:1739
See related
Ensembl:ENSG00000093009 MIM:603465; AllianceGenome:HGNC:1739
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC45L; MGORS7; CDC45L2; PORC-PI-1
Summary
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Biased expression in testis (RPKM 11.5), bone marrow (RPKM 6.8) and 11 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
22q11.21
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (19479466..19520612)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (19856299..19897453)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (19466989..19508135)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:19434430-19435332 Neighboring gene chromosome 22 open reading frame 39 Neighboring gene UFD1 antisense RNA 1 Neighboring gene ubiquitin recognition factor in ER associated degradation 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13463 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:19486137-19486353 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19493394-19493894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19493895-19494395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19502006-19502506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19502507-19503007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19509616-19510548 Neighboring gene claudin 5 Neighboring gene MPRA-validated peak4453 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19531837-19532336 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19542168-19542870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19542871-19543573 Neighboring gene long intergenic non-protein coding RNA 895

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Systematic pan‑cancer analysis identifies CDC45 as having an oncogenic role in human cancers. Lu Y, et al. Oncol Rep, 2022 Oct. PMID 36082823, Free PMC Article
  2. Knockdown of circular RNA hsa_circ_0062270 suppresses the progression of melanoma via downregulation of CDC45. Hao T, et al. Histol Histopathol, 2022 Apr. PMID 34931691
  3. A synonymous variant in a non-canonical exon of CDC45 disrupts splicing in two affected sibs with Meier-Gorlin syndrome with craniosynostosis. Knapp KM, et al. Eur J Med Genet, 2021 Apr. PMID 33639314
  4. Expression of Cell Division Cycle Protein 45 in Tissue Microarrays and the CDC45 Gene by Bioinformatics Analysis in Human Hepatocellular Carcinoma and Patient Outcomes. Lu HP, et al. Med Sci Monit, 2021 Feb 24. PMID 33622998, Free PMC Article
  5. Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45). Perl AL, et al. J Biol Chem, 2019 Nov 8. PMID 31562245, Free PMC Article

See all (118) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Validation of CDC45 as a novel biomarker for diagnosis and prognosis of gastric cancer.
    Title: Validation of CDC45 as a novel biomarker for diagnosis and prognosis of gastric cancer.
  2. IGF2BP2 promotes glycolysis and hepatocellular carcinoma stemness by stabilizing CDC45 mRNA via m6A modification.
    Title: IGF2BP2 promotes glycolysis and hepatocellular carcinoma stemness by stabilizing CDC45 mRNA via m6A modification.
  3. Systematic pancancer analysis identifies CDC45 as having an oncogenic role in human cancers.
    Title: Systematic pan‑cancer analysis identifies CDC45 as having an oncogenic role in human cancers.
  4. Knockdown of circular RNA hsa_circ_0062270 suppresses the progression of melanoma via downregulation of CDC45.
    Title: Knockdown of circular RNA hsa_circ_0062270 suppresses the progression of melanoma via downregulation of CDC45.
  5. CircCDC45 promotes the malignant progression of glioblastoma by modulating the miR-485-5p/CSF-1 axis.
    Title: CircCDC45 promotes the malignant progression of glioblastoma by modulating the miR-485-5p/CSF-1 axis.
  6. A synonymous variant in a non-canonical exon of CDC45 disrupts splicing in two affected sibs with Meier-Gorlin syndrome with craniosynostosis.
    Title: A synonymous variant in a non-canonical exon of CDC45 disrupts splicing in two affected sibs with Meier-Gorlin syndrome with craniosynostosis.
  7. Expression of Cell Division Cycle Protein 45 in Tissue Microarrays and the CDC45 Gene by Bioinformatics Analysis in Human Hepatocellular Carcinoma and Patient Outcomes.
    Title: Expression of Cell Division Cycle Protein 45 in Tissue Microarrays and the CDC45 Gene by Bioinformatics Analysis in Human Hepatocellular Carcinoma and Patient Outcomes.
  8. Pathogenic variants in CDC45 on the remaining allele in patients with a chromosome 22q11.2 deletion result in a novel autosomal recessive condition.
    Title: Pathogenic variants in CDC45 on the remaining allele in patients with a chromosome 22q11.2 deletion result in a novel autosomal recessive condition.
  9. Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45
    Title: Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45).
  10. RYBP suppresses esophageal squamous cell carcinoma proliferation by downregulating CDC6 and CDC45, thus inhibiting the G1-S transition
    Title: RYBP inhibits esophageal squamous cell carcinoma proliferation through downregulating CDC6 and CDC45 in G1-S phase transition process.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Meier-Gorlin syndrome 7
MedGen: C4310738 OMIM: 617063 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA replication checkpoint signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA unwinding involved in DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CMG complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of DNA replication preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell division control protein 45 homolog
Names
CDC45 cell division cycle 45 homolog
CDC45 cell division cycle 45-like
CDC45-related protein
cell division cycle 45 homolog
cell division cycle 45-like 2
human CDC45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052958.1 RefSeqGene

    Range
    5095..45783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178010.2 → NP_001171481.1  cell division control protein 45 homolog isoform 1

    See identical proteins and their annotated locations for NP_001171481.1

    Status: REVIEWED

    Source sequence(s)
    AC000088, AF081535, AK293338, HY016491
    Consensus CDS
    CCDS54499.1
    UniProtKB/Swiss-Prot
    O75419
    Related
    ENSP00000405726.2, ENST00000437685.6
    Conserved Domains (1) summary
    pfam02724
    Location:19 → 593
    CDC45; CDC45-like protein

  2. NM_001178011.2 → NP_001171482.1  cell division control protein 45 homolog isoform 3

    See identical proteins and their annotated locations for NP_001171482.1

    Status: REVIEWED

    Source sequence(s)
    AC000087, AF081535, AK293123, HY016491
    Consensus CDS
    CCDS54500.1
    UniProtKB/Swiss-Prot
    O75419
    Related
    ENSP00000384978.3, ENST00000404724.7
    Conserved Domains (1) summary
    pfam02724
    Location:19 → 515
    CDC45; CDC45-like protein

  3. NM_001369291.1 → NP_001356220.1  cell division control protein 45 homolog isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC000082, AC000087, AC000088
    Conserved Domains (1) summary
    pfam02724
    Location:7 → 549
    CDC45; CDC45-like protein

  4. NM_003504.5 → NP_003495.1  cell division control protein 45 homolog isoform 2

    See identical proteins and their annotated locations for NP_003495.1

    Status: REVIEWED

    Source sequence(s)
    AC000082, AC000087, AC000088
    Consensus CDS
    CCDS13762.1
    UniProtKB/Swiss-Prot
    B4DDB4, B4DDU3, E9PDH7, O60856, O75419, Q20WK8, Q6UW54, Q9UP68
    Related
    ENSP00000263201.2, ENST00000263201.7
    Conserved Domains (1) summary
    pfam02724
    Location:19 → 561
    CDC45; CDC45-like protein

RNA

  1. NR_161281.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC000082, AC000087, AC000088
    Related
    ENST00000438587.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    19479466..19520612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441534.1 → XP_047297490.1  cell division control protein 45 homolog isoform X8

  2. XM_047441531.1 → XP_047297487.1  cell division control protein 45 homolog isoform X1

  3. XM_047441532.1 → XP_047297488.1  cell division control protein 45 homolog isoform X2

    UniProtKB/Swiss-Prot
    B4DDB4, B4DDU3, E9PDH7, O60856, O75419, Q20WK8, Q6UW54, Q9UP68

  4. XM_011530417.4 → XP_011528719.1  cell division control protein 45 homolog isoform X4

    Conserved Domains (1) summary
    pfam02724
    Location:19 → 516
    CDC45; CDC45-like protein

  5. XM_011530418.4 → XP_011528720.1  cell division control protein 45 homolog isoform X5

    See identical proteins and their annotated locations for XP_011528720.1

    UniProtKB/Swiss-Prot
    O75419
    Conserved Domains (1) summary
    pfam02724
    Location:19 → 515
    CDC45; CDC45-like protein

  6. XM_011530416.2 → XP_011528718.1  cell division control protein 45 homolog isoform X3

    Conserved Domains (1) summary
    pfam02724
    Location:7 → 550
    CDC45; CDC45-like protein

  7. XM_047441533.1 → XP_047297489.1  cell division control protein 45 homolog isoform X6

    Related
    ENSP00000499976.1, ENST00000672837.1

  8. XM_017028966.2 → XP_016884455.1  cell division control protein 45 homolog isoform X7

    UniProtKB/TrEMBL
    A0A5K1VW85
    Related
    ENSP00000385240.2, ENST00000407835.6
    Conserved Domains (1) summary
    pfam02724
    Location:4 → 392
    CDC45; CDC45-like protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    19856299..19897453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325997.1 → XP_054181972.1  cell division control protein 45 homolog isoform X8

  2. XM_054325990.1 → XP_054181965.1  cell division control protein 45 homolog isoform X1

  3. XM_054325991.1 → XP_054181966.1  cell division control protein 45 homolog isoform X2

    UniProtKB/Swiss-Prot
    B4DDB4, B4DDU3, E9PDH7, O60856, O75419, Q20WK8, Q6UW54, Q9UP68

  4. XM_054325993.1 → XP_054181968.1  cell division control protein 45 homolog isoform X4

  5. XM_054325994.1 → XP_054181969.1  cell division control protein 45 homolog isoform X5

  6. XM_054325992.1 → XP_054181967.1  cell division control protein 45 homolog isoform X3

  7. XM_054325995.1 → XP_054181970.1  cell division control protein 45 homolog isoform X6

  8. XM_054325996.1 → XP_054181971.1  cell division control protein 45 homolog isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75419.1 GenPept UniProtKB/Swiss-Prot:O75419

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