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CPL2 carboxyl-terminal domain (ctd) phosphatase-like 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831743, updated on 18-Sep-2024

Summary

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Official Symbol
CPL2
Official Full Name
carboxyl-terminal domain (ctd) phosphatase-like 2
Primary source
TAIR:AT5G01270
Locus tag
AT5G01270
See related
Araport:AT5G01270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATCPL2; carboxyl-terminal domain (ctd) phosphatase-like 2; F7J8.250; F7J8_250
Summary
Encodes CPL2, a carboxyl-terminal domain (CTD) phosphatase that dephosphorylates CTD Ser5-PO4 of the RNA polymerase II complex. Regulates plant growth, stress and auxin responses.
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Genomic context

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See CPL2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
14
Sequence:
Chromosome: 5; NC_003076.8 (107547..112324, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene alpha 1,4-glycosyltransferase family protein Neighboring gene Carbohydrate-binding-like fold Neighboring gene GPI-anchored protein Neighboring gene mRNA capping enzyme family protein Neighboring gene PEBP (phosphatidylethanolamine-binding protein) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CPL2 and CPL3 act redundantly in FLC activation and flowering time regulation in Arabidopsis. Zhang Y, et al. Plant Signal Behav, 2022 Dec 31. PMID 35112651, Free PMC Article
  2. The Arabidopsis thaliana carboxyl-terminal domain phosphatase-like 2 regulates plant growth, stress and auxin responses. Ueda A, et al. Plant Mol Biol, 2008 Aug. PMID 18506580
  3. KH domain protein RCF3 is a tissue-biased regulator of the plant miRNA biogenesis cofactor HYL1. Karlsson P, et al. Proc Natl Acad Sci U S A, 2015 Nov 10. PMID 26512101, Free PMC Article
  4. Arabidopsis C-terminal domain phosphatase-like 1 and 2 are essential Ser-5-specific C-terminal domain phosphatases. Koiwa H, et al. Proc Natl Acad Sci U S A, 2004 Oct 5. PMID 15388846, Free PMC Article
  5. Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis. Zhang YZ, et al. Nat Commun, 2020 Dec 4. PMID 33277495, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis plants that express CPL2 mutants exhibited leaf expansion defects, early flowering, low fertility, and increased salt sensitivity.
    Title: The Arabidopsis thaliana carboxyl-terminal domain phosphatase-like 2 regulates plant growth, stress and auxin responses.
  2. The mechanisms of reading the CTD code by two classes of protein phosphatases, plant CPLs and yeast Ssu72, that specifically dephosphorylate Ser(5) in vitro are reported.
    Title: Different strategies for carboxyl-terminal domain (CTD) recognition by serine 5-specific CTD phosphatases.
Submit: New GeneRIF Correction

General gene information

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NM_001203270.1
NM_120205.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in auxin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within developmental growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of gene expression, epigenetic IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of photoperiodism, flowering IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within_negative_effect regulation of photoperiodism, flowering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to auxin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within wax biosynthetic process IMP
Inferred from Mutant Phenotype
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
carboxyl-terminal domain (ctd) phosphatase-like 2
NP_001190199.1
  • carboxyl-terminal domain (ctd) phosphatase-like 2 (CPL2); FUNCTIONS IN: double-stranded RNA binding, phosphatase activity; INVOLVED IN: response to auxin stimulus, response to osmotic stress, developmental growth; LOCATED IN: intracellular; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Double-stranded RNA-binding (InterPro:IPR001159), Double-stranded RNA-binding-like (InterPro:IPR014720), NLI interacting factor (InterPro:IPR004274); BEST Arabidopsis thaliana protein match is: C-terminal domain phosphatase-like 1 (TAIR:AT4G21670.1).
NP_195747.2
  • carboxyl-terminal domain (ctd) phosphatase-like 2 (CPL2); FUNCTIONS IN: double-stranded RNA binding, phosphatase activity; INVOLVED IN: response to auxin stimulus, response to osmotic stress, developmental growth; LOCATED IN: intracellular; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Double-stranded RNA-binding (InterPro:IPR001159), Double-stranded RNA-binding-like (InterPro:IPR014720), NLI interacting factor (InterPro:IPR004274); BEST Arabidopsis thaliana protein match is: C-terminal domain phosphatase-like 1 (TAIR:AT4G21670.1); Has 234 Blast hits to 223 proteins in 82 species: Archae - 0; Bacteria - 8; Metazoa - 40; Fungi - 61; Plants - 110; Viruses - 0; Other Eukaryotes - 15 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    107547..112324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120205.5 → NP_195747.2  carboxyl-terminal domain (ctd) phosphatase-like 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195747.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4K803, Q5YDB5, Q9LFA9
    UniProtKB/TrEMBL
    A0A178UG98, A0A7G2F9J5
    Conserved Domains (3) summary
    PHA03247
    Location:461 → 654
    PHA03247; large tegument protein UL36; Provisional
    cd07521
    Location:244 → 355
    HAD_FCP1-like; human CTD phosphatase subunit 1 (CTDP1/FCP1) and related proteins; belongs to the haloacid dehalogenase-like superfamily
    cd10845
    Location:657 → 720
    DSRM_RNAse_III_family; double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins

  2. NM_001203270.1 → NP_001190199.1  carboxyl-terminal domain (ctd) phosphatase-like 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190199.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2F9J5, F4K802
    Conserved Domains (2) summary
    pfam00035
    Location:658 → 720
    dsrm; Double-stranded RNA binding motif
    cl21460
    Location:255 → 348
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5YDB5.3

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