HD2C histone deacetylase 2C [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: HD2C
Official Full Name: histone deacetylase 2C
Primary source: TAIR:AT5G03740
Locus tag: AT5G03740
See related: Araport:AT5G03740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F17C15.160; F17C15_160; HDT3; histone deacetylase 2C; HISTONE DEACETYLASE 3
Summary: HD2-type histone deacetylase HDAC. Involved in the ABA and stress responses. Mediates transcriptional repression
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

this study reveals a multifaceted role of HD2C in ribosome biogenesis.
Title: Canonical and Noncanonical Actions of Arabidopsis Histone Deacetylases in Ribosomal RNA Processing.
HD2C and BRM act in a common genetic pathway to regulate the Arabidopsis heat stress response.
Title: HD2C histone deacetylase and a SWI/SNF chromatin remodelling complex interact and both are involved in mediating the heat stress response in Arabidopsis.
HD2C functionally associates with HDA6 and regulates gene expression through histone modifications.
Title: HD2C interacts with HDA6 and is involved in ABA and salt stress response in Arabidopsis.
HD2A and HD2C may have different and opposing functions in germination with the glucose/HD2A pathway acting to restrain germination and the HD2C pathway acting to enhance germination.
Title: Role of HD2 genes in seed germination and early seedling growth in Arabidopsis.
AtHD2C can modulate abscisic acid and stress responses.
Title: Identification of AtHD2C as a novel regulator of abscisic acid responses in Arabidopsis.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_120455.4

Function	Evidence Code	Pubs
enables histone deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleolus	HDA more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	HDA more info	PubMed

NP_195994.3

histone deacetylase 2C (HD2C); FUNCTIONS IN: histone deacetylase activity, transcription repressor activity, zinc ion binding, nucleic acid binding; INVOLVED IN: response to water deprivation, response to salt stress, response to abscisic acid stimulus; LOCATED IN: nucleolus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, C2H2-like (InterPro:IPR015880), Zinc finger, C2H2-type (InterPro:IPR007087); BEST Arabidopsis thaliana protein match is: histone deacetylase 3 (TAIR:AT3G44750.2); Has 47549 Blast hits to 20091 proteins in 1212 species: Archae - 111; Bacteria - 17827; Metazoa - 12467; Fungi - 4889; Plants - 1882; Viruses - 518; Other Eukaryotes - 9855 (source: NCBI BLink).