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CDC7 cell division cycle 7 [ Homo sapiens (human) ]

Gene ID: 8317, updated on 3-Apr-2024

Summary

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Official Symbol
CDC7provided by HGNC
Official Full Name
cell division cycle 7provided by HGNC
Primary source
HGNC:HGNC:1745
See related
Ensembl:ENSG00000097046 MIM:603311; AllianceGenome:HGNC:1745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Hsk1; CDC7L1; HsCDC7; huCDC7
Summary
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]
Expression
Broad expression in testis (RPKM 10.5), lymph node (RPKM 4.8) and 19 other tissues See more
Orthologs
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Genomic context

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See CDC7 in Genome Data Viewer
Location:
1p22.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (91500851..91525764)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (91343613..91370396)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (91966408..91991321)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985417 Neighboring gene uncharacterized LOC105378856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1303 Neighboring gene uncharacterized LOC102723436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1304 Neighboring gene WD repeat domain 82 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1305 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:92047752-92048951 Neighboring gene ribosomal protein L39 pseudogene 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel insights into the roles of Cdc7 in response to replication stress. González-Garrido C, et al. FEBS J, 2023 Jun. PMID 35398961
  2. Upregulation of CDC7 Associated with Cervical Cancer Incidence and Development. Wang Q, et al. Biomed Res Int, 2021. PMID 33763482, Free PMC Article
  3. CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage. Rainey MD, et al. EMBO Rep, 2020 Aug 5. PMID 32496651, Free PMC Article
  4. Immunohistochemical Expression of CDC7 in Dentigerous Cyst, Odontogenic Keratocyst and Radicular Cyst. Jaafari-Ashkavandi Z, et al. Acta Medica (Hradec Kralove), 2018. PMID 30012245
  5. Cell division cycle 7 is a potential therapeutic target in oral squamous cell carcinoma and is regulated by E2F1. Jin S, et al. J Mol Med (Berl), 2018 Jun. PMID 29713760

See all (122) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase.
    Title: Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase.
  2. DBF4 Dependent Kinase Inhibition Suppresses Hepatocellular Carcinoma Progression and Potentiates Anti-Programmed Cell Death-1 Therapy.
    Title: DBF4 Dependent Kinase Inhibition Suppresses Hepatocellular Carcinoma Progression and Potentiates Anti-Programmed Cell Death-1 Therapy.
  3. Novel insights into the roles of Cdc7 in response to replication stress.
    Title: Novel insights into the roles of Cdc7 in response to replication stress.
  4. Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer.
    Title: Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer.
  5. MiR-200a with CDC7 as a direct target declines cell viability and promotes cell apoptosis in Wilm's tumor via Wnt/beta-catenin signaling pathway.
    Title: MiR-200a with CDC7 as a direct target declines cell viability and promotes cell apoptosis in Wilm's tumor via Wnt/β-catenin signaling pathway.
  6. Upregulation of CDC7 Associated with Cervical Cancer Incidence and Development.
    Title: Upregulation of CDC7 Associated with Cervical Cancer Incidence and Development.
  7. ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition.
    Title: ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition.
  8. CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage.
    Title: CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage.
  9. Cdc7 kinase stimulates Aurora B kinase in M-phase.
    Title: Cdc7 kinase stimulates Aurora B kinase in M-phase.
  10. Targeting CDC7 sensitizes resistance melanoma cells to BRAF(V600E)-specific inhibitor by blocking the CDC7/MCM2-7 pathway.
    Title: Targeting CDC7 sensitizes resistance melanoma cells to BRAF(V600E)-specific inhibitor by blocking the CDC7/MCM2-7 pathway.
Submit: New GeneRIF Correction See all GeneRIFs (64)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of optic disc parameters.
EBI GWAS Catalog
Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117361, MGC126237, MGC126238

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nuclear cell cycle DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell division cycle 7-related protein kinase
Names
CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1
CDC7-related kinase
cell division cycle 7 homolog
cell division cycle 7-like protein 1
epididymis secretory sperm binding protein
NP_001127891.1
NP_001127892.1
NP_003494.1
XP_005271298.1
XP_005271301.1
XP_016857914.1
XP_016857915.1
XP_016857916.1
XP_024305858.1
XP_047287315.1
XP_047287320.1
XP_047287321.1
XP_047287328.1
XP_047287329.1
XP_047287330.1
XP_047287331.1
XP_047287332.1
XP_054194913.1
XP_054194914.1
XP_054194915.1
XP_054194916.1
XP_054194917.1
XP_054194918.1
XP_054194919.1
XP_054194920.1
XP_054194921.1
XP_054194922.1
XP_054194923.1
XP_054194924.1
XP_054194925.1
XP_054194926.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134419.2 → NP_001127891.1  cell division cycle 7-related protein kinase

    See identical proteins and their annotated locations for NP_001127891.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI672674, BC110526, BC111044, DA791490, N62245
    Consensus CDS
    CCDS734.1
    UniProtKB/Swiss-Prot
    D3DT31, O00311, O00558, Q5T5U5
    UniProtKB/TrEMBL
    A0A384MTU6, B2R6V2
    Conserved Domains (2) summary
    cd14019
    Location:56 → 438
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:293 → 419
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001134420.2 → NP_001127892.1  cell division cycle 7-related protein kinase

    See identical proteins and their annotated locations for NP_001127892.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses a different segment for part of its 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI672674, AK312726, BC111044, DA127303, N62245
    Consensus CDS
    CCDS734.1
    UniProtKB/Swiss-Prot
    D3DT31, O00311, O00558, Q5T5U5
    UniProtKB/TrEMBL
    A0A384MTU6, B2R6V2
    Related
    ENSP00000393139.1, ENST00000428239.5
    Conserved Domains (2) summary
    cd14019
    Location:56 → 438
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:293 → 419
    PKc_like; Protein Kinases, catalytic domain

  3. NM_003503.4 → NP_003494.1  cell division cycle 7-related protein kinase

    See identical proteins and their annotated locations for NP_003494.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the most commonly occurring transcript. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI672674, BC111044, DA791490, N62245
    Consensus CDS
    CCDS734.1
    UniProtKB/Swiss-Prot
    D3DT31, O00311, O00558, Q5T5U5
    UniProtKB/TrEMBL
    A0A384MTU6, B2R6V2
    Related
    ENSP00000234626.6, ENST00000234626.11
    Conserved Domains (2) summary
    cd14019
    Location:56 → 438
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:293 → 419
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    91500851..91525764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271244.4 → XP_005271301.1  cell division cycle 7-related protein kinase isoform X2

    UniProtKB/TrEMBL
    B2R6V2
    Conserved Domains (3) summary
    cd14019
    Location:56 → 406
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    pfam00069
    Location:58 → 417
    Pkinase; Protein kinase domain
    cl21453
    Location:314 → 537
    PKc_like; Protein Kinases, catalytic domain

  2. XM_017002426.2 → XP_016857915.1  cell division cycle 7-related protein kinase isoform X2

    UniProtKB/TrEMBL
    B2R6V2
    Conserved Domains (3) summary
    cd14019
    Location:56 → 406
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    pfam00069
    Location:58 → 417
    Pkinase; Protein kinase domain
    cl21453
    Location:314 → 537
    PKc_like; Protein Kinases, catalytic domain

  3. XM_017002427.3 → XP_016857916.1  cell division cycle 7-related protein kinase isoform X3

    UniProtKB/TrEMBL
    B7Z5H7
    Conserved Domains (1) summary
    cl21453
    Location:1 → 321
    PKc_like; Protein Kinases, catalytic domain

  4. XM_047431372.1 → XP_047287328.1  cell division cycle 7-related protein kinase isoform X4

  5. XM_005271241.3 → XP_005271298.1  cell division cycle 7-related protein kinase isoform X1

    See identical proteins and their annotated locations for XP_005271298.1

    UniProtKB/Swiss-Prot
    D3DT31, O00311, O00558, Q5T5U5
    UniProtKB/TrEMBL
    A0A384MTU6, B2R6V2
    Conserved Domains (2) summary
    cd14019
    Location:56 → 438
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:293 → 419
    PKc_like; Protein Kinases, catalytic domain

  6. XM_017002425.3 → XP_016857914.1  cell division cycle 7-related protein kinase isoform X2

    UniProtKB/TrEMBL
    B2R6V2
    Conserved Domains (3) summary
    cd14019
    Location:56 → 406
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    pfam00069
    Location:58 → 417
    Pkinase; Protein kinase domain
    cl21453
    Location:314 → 537
    PKc_like; Protein Kinases, catalytic domain

  7. XM_047431374.1 → XP_047287330.1  cell division cycle 7-related protein kinase isoform X5

  8. XM_047431373.1 → XP_047287329.1  cell division cycle 7-related protein kinase isoform X5

  9. XM_047431376.1 → XP_047287332.1  cell division cycle 7-related protein kinase isoform X6

  10. XM_047431375.1 → XP_047287331.1  cell division cycle 7-related protein kinase isoform X5

  11. XM_047431364.1 → XP_047287320.1  cell division cycle 7-related protein kinase isoform X2

  12. XM_047431359.1 → XP_047287315.1  cell division cycle 7-related protein kinase isoform X1

    UniProtKB/Swiss-Prot
    D3DT31, O00311, O00558, Q5T5U5
    UniProtKB/TrEMBL
    A0A384MTU6

  13. XM_024450090.2 → XP_024305858.1  cell division cycle 7-related protein kinase isoform X1

    UniProtKB/Swiss-Prot
    D3DT31, O00311, O00558, Q5T5U5
    UniProtKB/TrEMBL
    A0A384MTU6, B2R6V2
    Conserved Domains (2) summary
    cd14019
    Location:56 → 438
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:293 → 419
    PKc_like; Protein Kinases, catalytic domain

  14. XM_047431365.1 → XP_047287321.1  cell division cycle 7-related protein kinase isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    91343613..91370396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338941.1 → XP_054194916.1  cell division cycle 7-related protein kinase isoform X1

    UniProtKB/Swiss-Prot
    D3DT31, O00311, O00558, Q5T5U5
    UniProtKB/TrEMBL
    A0A384MTU6

  2. XM_054338940.1 → XP_054194915.1  cell division cycle 7-related protein kinase isoform X1

    UniProtKB/Swiss-Prot
    D3DT31, O00311, O00558, Q5T5U5
    UniProtKB/TrEMBL
    A0A384MTU6

  3. XM_054338946.1 → XP_054194921.1  cell division cycle 7-related protein kinase isoform X2

  4. XM_054338942.1 → XP_054194917.1  cell division cycle 7-related protein kinase isoform X2

  5. XM_054338944.1 → XP_054194919.1  cell division cycle 7-related protein kinase isoform X2

  6. XM_054338947.1 → XP_054194922.1  cell division cycle 7-related protein kinase isoform X3

  7. XM_054338948.1 → XP_054194923.1  cell division cycle 7-related protein kinase isoform X4

  8. XM_054338949.1 → XP_054194924.1  cell division cycle 7-related protein kinase isoform X5

  9. XM_054338951.1 → XP_054194926.1  cell division cycle 7-related protein kinase isoform X6

  10. XM_054338950.1 → XP_054194925.1  cell division cycle 7-related protein kinase isoform X5

  11. XM_054338938.1 → XP_054194913.1  cell division cycle 7-related protein kinase isoform X1

    UniProtKB/Swiss-Prot
    D3DT31, O00311, O00558, Q5T5U5
    UniProtKB/TrEMBL
    A0A384MTU6

  12. XM_054338943.1 → XP_054194918.1  cell division cycle 7-related protein kinase isoform X2

  13. XM_054338939.1 → XP_054194914.1  cell division cycle 7-related protein kinase isoform X1

    UniProtKB/Swiss-Prot
    D3DT31, O00311, O00558, Q5T5U5
    UniProtKB/TrEMBL
    A0A384MTU6

  14. XM_054338945.1 → XP_054194920.1  cell division cycle 7-related protein kinase isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00311.1 GenPept UniProtKB/Swiss-Prot:O00311

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