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CAC1 chloroplastic acetylcoenzyme A carboxylase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831500, updated on 18-Sep-2024

Summary

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Official Symbol
CAC1
Official Full Name
chloroplastic acetylcoenzyme A carboxylase 1
Primary source
TAIR:AT5G16390
Locus tag
AT5G16390
See related
Araport:AT5G16390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
BCCP; BCCP-1; BCCP1; BIOTIN CARBOXYL CARRIER PROTEIN; BIOTIN CARBOXYL-CARRIER PROTEIN; BIOTIN CARBOXYL-CARRIER PROTEIN 1; CAC1-A; CAC1A; chloroplastic acetylcoenzyme A carboxylase 1; MQK4.12; MQK4_12
Summary
Encodes for the biotin carboxyl-carrier subunit of the multi-enzyme plastidial acetyl-coenzyme A carboxylase complex.
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Genomic context

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See CAC1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Sequence:
Chromosome: 5; NC_003076.8 (5360789..5363297, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene autophagy-like protein, putative (Protein of unknown function, DUF538) Neighboring gene thioredoxin F2 Neighboring gene HXXXD-type acyl-transferase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of the cDNA coding for the biotin-containing subunit of the chloroplastic acetyl-coenzyme A carboxylase. Choi JK, et al. Plant Physiol, 1995 Oct. PMID 7480350, Free PMC Article
  2. Reverse-genetic analysis of the two biotin-containing subunit genes of the heteromeric acetyl-coenzyme A carboxylase in Arabidopsis indicates a unidirectional functional redundancy. Li X, et al. Plant Physiol, 2011 Jan. PMID 21030508, Free PMC Article
  3. Brassicaceae express multiple isoforms of biotin carboxyl carrier protein in a tissue-specific manner. Thelen JJ, et al. Plant Physiol, 2001 Apr. PMID 11299381, Free PMC Article
  4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
  5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BCCP1 protein can compensate for the lack of BCCP2, the absence of BCCP1 cannot be tolerated as BCCP2 levels are not sufficient to support heteromeric acetyl-coenzyme A carboxylase activity at a level that is required for normal growth and development.
    Title: Reverse-genetic analysis of the two biotin-containing subunit genes of the heteromeric acetyl-coenzyme A carboxylase in Arabidopsis indicates a unidirectional functional redundancy.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_121644.4
NM_203060.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables acetyl-CoA carboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetyl-CoA carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables biotin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of acetyl-CoA carboxylase complex IEA
Inferred from Electronic Annotation
more info
  
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in chloroplast envelope HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in plastid HDA PubMed 

General protein information

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Preferred Names
chloroplastic acetylcoenzyme A carboxylase 1
NP_197143.1
  • chloroplastic acetylcoenzyme A carboxylase 1 (CAC1); FUNCTIONS IN: acetyl-CoA carboxylase activity, biotin binding; INVOLVED IN: fatty acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Biotin-binding site (InterPro:IPR001882), Single hybrid motif (InterPro:IPR011053), Acetyl-CoA biotin carboxyl carrier (InterPro:IPR001249), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: biotin carboxyl carrier protein 2 (TAIR:AT5G15530.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
NP_974789.1
  • BIOTIN CARBOXYL-CARRIER PROTEIN 1 (BCCP-1); FUNCTIONS IN: acetyl-CoA carboxylase activity, biotin binding; INVOLVED IN: fatty acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Acetyl-CoA biotin carboxyl carrier (InterPro:IPR001249), Single hybrid motif (InterPro:IPR011053), Biotin/lipoyl attachment (InterPro:IPR000089); BEST Arabidopsis thaliana protein match is: biotin carboxyl carrier protein 2 (TAIR:AT5G15530.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    5360789..5363297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121644.4 → NP_197143.1  chloroplastic acetylcoenzyme A carboxylase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197143.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04845, Q42533, Q9LL78
    UniProtKB/TrEMBL
    A0A178ULU5, A0A5S9Y5B4
    Conserved Domains (1) summary
    PLN02983
    Location:1 → 280
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase

  2. NM_203060.2 → NP_974789.1  chloroplastic acetylcoenzyme A carboxylase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974789.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178ULR4, F4KE21
    Conserved Domains (2) summary
    PLN02983
    Location:1 → 251
    PLN02983; biotin carboxyl carrier protein of acetyl-CoA carboxylase
    pfam00364
    Location:205 → 251
    Biotin_lipoyl; Biotin-requiring enzyme
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q42533.2

Gene LinkOut

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