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ZIF1 zinc induced facilitator 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831219, updated on 18-Sep-2024

Summary

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Official Symbol
ZIF1
Official Full Name
zinc induced facilitator 1
Primary source
TAIR:AT5G13740
Locus tag
AT5G13740
See related
Araport:AT5G13740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MSH12.21; MSH12_21; zinc induced facilitator 1
Summary
Encodes ZIF1 (ZINC-INDUCED FACILITATOR1), a member of the Major Facilitator Superfamily (MFS) of membrane proteins which are found in all organisms and transport a wide range of small, organic molecules. Involved in a mechanism of Zn sequestration, possibly by transport of a Zn ligand or Zn-ligand complex into vacuoles.
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Genomic context

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See ZIF1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
18
Sequence:
Chromosome: 5; NC_003076.8 (4432297..4437148)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene sterol methyltransferase 1 Neighboring gene Uncharacterized protein family (UPF0114) Neighboring gene sigma factor 4 Neighboring gene zinc induced facilitator-like 1 Neighboring gene Plasma-membrane choline transporter family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vacuolar nicotianamine has critical and distinct roles under iron deficiency and for zinc sequestration in Arabidopsis. Haydon MJ, et al. Plant Cell, 2012 Feb. PMID 22374397, Free PMC Article
  2. A novel major facilitator superfamily protein at the tonoplast influences zinc tolerance and accumulation in Arabidopsis. Haydon MJ, et al. Plant Physiol, 2007 Apr. PMID 17277087, Free PMC Article
  3. Functional overlap of two major facilitator superfamily transporter, ZIF1, and ZIFL1 in zinc and iron homeostasis. Lee S, et al. Biochem Biophys Res Commun, 2021 Jun 30. PMID 33964505
  4. Nematode-induced changes of transporter gene expression in Arabidopsis roots. Hammes UZ, et al. Mol Plant Microbe Interact, 2005 Dec. PMID 16478044
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

General gene information

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NM_121377.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to nematode HEP PubMed 
acts_upstream_of_or_within response to zinc ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in plant-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc induced facilitator 1
NP_196878.2
  • zinc induced facilitator 1 (ZIF1); FUNCTIONS IN: carbohydrate transmembrane transporter activity, tetracycline:hydrogen antiporter activity, sugar:hydrogen symporter activity; INVOLVED IN: response to zinc ion, zinc ion homeostasis, response to nematode; LOCATED IN: plant-type vacuole membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Major facilitator superfamily (InterPro:IPR020846), Tetracycline resistance protein, TetA (InterPro:IPR001958), Major facilitator superfamily MFS-1 (InterPro:IPR011701), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: zinc induced facilitator-like 1 (TAIR:AT5G13750.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    4432297..4437148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001343291.1 → NP_001331803.1  zinc induced facilitator 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UIX9, A0A1P8BEY5, A0A5S9Y3V4

  2. NM_121377.5 → NP_196878.2  zinc induced facilitator 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196878.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RWN2, Q9FKI8
    UniProtKB/TrEMBL
    A0A178UIX9, A0A5S9Y3V4, A0A654G0R7
    Conserved Domains (1) summary
    cd17330
    Location:42 → 444
    MFS_SLC46_TetA_like; Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8RWN2.2

Gene LinkOut

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