ROC1 rotamase CYP 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ROC1
Official Full Name: rotamase CYP 1
Primary source: TAIR:AT4G38740
Locus tag: AT4G38740
See related: Araport:AT4G38740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CYCLOPHILIN; rotamase CYP 1; T9A14.20; T9A14_20
Summary: Encodes cytosolic cyclophilin ROC1.
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Genomic context

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See ROC1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (18083395..18084630, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Consistent with this, RIN4 Pro149 undergoes cis/trans isomerization in the presence of ROC1.
Title: Proline isomerization of the immune receptor-interacting protein RIN4 by a cyclophilin inhibits effector-triggered immunity in Arabidopsis.
Roc1, and Roc2 binds to the Tomato bushy stunt tombusvirus RNA and replication proteins, resulting in inhibition of virus repication.
Title: Cyclophilin A binds to the viral RNA and replication proteins, resulting in inhibition of tombusviral replicase assembly.
A gain-of-function mutation in a highly conserved Arabidopsis CyP gene, ROC1, causes a dramatic alteration of plant architecture.
Title: A gain-of-function mutation in the ROC1 gene alters plant architecture in Arabidopsis.
Perception of light by phyA, cry1 or phyB activates ROC1; this in turn reduces the intensity of brassinosteroid signalling and fine-tunes seedling de-etiolation.
Title: The cyclophilin ROC1 links phytochrome and cryptochrome to brassinosteroid sensitivity.
activates Pseudomonas syringiae AvrRpt2
Title: Activation of a phytopathogenic bacterial effector protein by a eukaryotic cyclophilin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_120034.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables peptidyl-prolyl cis-trans isomerase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within blue light signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within brassinosteroid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within de-etiolation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within red, far-red light phototransduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: rotamase CYP 1

NP_195585.1

rotamase CYP 1 (ROC1); FUNCTIONS IN: peptidyl-prolyl cis-trans isomerase activity; INVOLVED IN: protein folding, response to cadmium ion, signal transduction; LOCATED IN: cytosol, apoplast, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (InterPro:IPR020892); BEST Arabidopsis thaliana protein match is: Cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein (TAIR:AT2G21130.1); Has 16514 Blast hits to 16480 proteins in 2670 species: Archae - 108; Bacteria - 6825; Metazoa - 2927; Fungi - 1383; Plants - 1289; Viruses - 4; Other Eukaryotes - 3978 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

18083395..18084630 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120034.2 → NP_195585.1 rotamase CYP 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195585.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34790, Q0WWG0

UniProtKB/TrEMBL

A0A178V2S8, A0A178VU06, A0A5S9Y0A1

Conserved Domains (1) summary

cd01926
Location:4 → 169

cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...