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CGL1 alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829981, updated on 18-Sep-2024

Summary

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Official Symbol
CGL1
Official Full Name
alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Primary source
TAIR:AT4G38240
Locus tag
AT4G38240
See related
Araport:AT4G38240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
CGL; COMPLEX GLYCAN LESS; COMPLEX GLYCAN LESS 1; F20D10.360; F20D10_360; GNTI; N-ACETYLGLUCOSAMINYLTRANSFERASE I
Summary
Encodes N-acetyl glucosaminyl transferase I, the first enzyme in the pathway of complex glycan biosynthesis.
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Genomic context

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See CGL1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
19
Sequence:
Chromosome: 4; NC_003075.7 (17931570..17935325, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Peptidase M20/M25/M40 family protein Neighboring gene glycerol kinase Neighboring gene calcium-dependent protein kinase 26 Neighboring gene Transmembrane amino acid transporter family protein Neighboring gene ncRNA Neighboring gene transport/golgi organization-like protein (DUF833) Neighboring gene galacturonosyltransferase 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Golgi Localization of GnTI Requires a Polar Amino Acid Residue within Its Transmembrane Domain. Schoberer J, et al. Plant Physiol, 2019 Jun. PMID 30971450, Free PMC Article
  2. Comparative analyses of Arabidopsis complex glycan1 mutants and genetic interaction with staurosporin and temperature sensitive3a. Frank J, et al. Plant Physiol, 2008 Nov. PMID 18768906, Free PMC Article
  3. Molecular basis of N-acetylglucosaminyltransferase I deficiency in Arabidopsis thaliana plants lacking complex N-glycans. Strasser R, et al. Biochem J, 2005 Apr 15. PMID 15537386, Free PMC Article
  4. An Arabidopsis thaliana cDNA complements the N-acetylglucosaminyltransferase I deficiency of CHO Lec1 cells. Bakker H, et al. Biochem Biophys Res Commun, 1999 Aug 11. PMID 10441510
  5. Isolation of a mutant Arabidopsis plant that lacks N-acetyl glucosaminyl transferase I and is unable to synthesize Golgi-modified complex N-linked glycans. von Schaewen A, et al. Plant Physiol, 1993 Aug. PMID 8278542, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001204022.1
NM_119986.3
NM_179186.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein N-acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within N-glycan processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hyperosmotic response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in Golgi apparatus IC
Inferred by Curator
more info
 PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISM
Inferred from Sequence Model
more info
  
located_in Golgi apparatus TAS
Traceable Author Statement
more info
 PubMed 
located_in Golgi medial cisterna HDA PubMed 
located_in endosome HDA PubMed 
located_in trans-Golgi network HDA PubMed 

General protein information

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Preferred Names
alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NP_001190951.1
  • COMPLEX GLYCAN LESS 1 (CGL1); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 13 (InterPro:IPR004139).
NP_195537.2
  • COMPLEX GLYCAN LESS 1 (CGL1); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 13 (InterPro:IPR004139); Has 453 Blast hits to 453 proteins in 90 species: Archae - 0; Bacteria - 4; Metazoa - 330; Fungi - 0; Plants - 71; Viruses - 0; Other Eukaryotes - 48 (source: NCBI BLink).
NP_849517.1
  • COMPLEX GLYCAN LESS 1 (CGL1); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 13 (InterPro:IPR004139); Has 453 Blast hits to 453 proteins in 90 species: Archae - 0; Bacteria - 4; Metazoa - 330; Fungi - 0; Plants - 71; Viruses - 0; Other Eukaryotes - 48 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    17931570..17935325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_119986.3 → NP_195537.2  alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_195537.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8VWR5, Q9SVG1, Q9SZM4, Q9XGM8
    UniProtKB/TrEMBL
    A0A178UU47, W8Q2W3
    Conserved Domains (2) summary
    pfam03071
    Location:13 → 443
    GNT-I; GNT-I family
    pfam13641
    Location:107 → 310
    Glyco_tranf_2_3; Glycosyltransferase like family 2

  2. NM_179186.1 → NP_849517.1  alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849517.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8VWR5, Q9SVG1, Q9SZM4, Q9XGM8
    UniProtKB/TrEMBL
    A0A178UU47, W8Q2W3
    Conserved Domains (2) summary
    pfam03071
    Location:13 → 443
    GNT-I; GNT-I family
    pfam13641
    Location:107 → 310
    Glyco_tranf_2_3; Glycosyltransferase like family 2

  3. NM_001204022.1 → NP_001190951.1  alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190951.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FWP6, A0A7G2F5N7, F4JTL6
    Conserved Domains (1) summary
    pfam03071
    Location:13 → 432
    GNT-I; GNT-I family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XGM8.1

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