CIB1 cryptochrome-interacting basic-helix-loop-helix 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CIB1
Official Full Name: cryptochrome-interacting basic-helix-loop-helix 1
Primary source: TAIR:AT4G34530
Locus tag: AT4G34530
See related: Araport:AT4G34530
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: cryptochrome-interacting basic-helix-loop-helix 1; T4L20.110; T4L20_110
Summary: Encodes a transcription factor CIB1 (cryptochrome-interacting basic-helix-loop-helix). CIB1 interacts with CRY2 (cryptochrome 2) in a blue light-specific manner in yeast and Arabidopsis cells, and it acts together with additional CIB1-related proteins to promote CRY2-dependent floral initiation. CIB1 positively regulates FT expression.
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Genomic context

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See CIB1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 6

Sequence:: Chromosome: 4; NC_003075.7 (16498391..16500174)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The CIB1 transcription factor regulates light- and heat-inducible cell elongation via a two-step HLH/bHLH system.
Title: The CIB1 transcription factor regulates light- and heat-inducible cell elongation via a two-step HLH/bHLH system.
We also determined that CRY2 was recruited to the FT chromatin by CIB1 and CO and that all three proteins are bound to the same region within the FT promoter. Therefore, there is crosstalk between the CRY2-CO and CRY2-CIBs pathways, and CIB1 and CO act together to regulate FT transcription and flowering.
Title: CIB1 and CO interact to mediate CRY2-dependent regulation of flowering.
CRY2-CIB1 and CRY2-CRY2 interactions are governed by well-separated protein interfaces at the two termini of CRY2.
Title: Understanding CRY2 interactions for optical control of intracellular signaling.
It describes minimal functional CRY2 and CIB1 domains maintaining light-dependent interaction and new signaling mutations affecting Arabidopsis thaliana cryptochrome 2 (AtCRY2) photocycle kinetics.
Title: Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase.
Data indicate that although cryptochrome 2 physically interacts with CIB1 in response to blue light, ZEITLUPE and LOV KELCH PROTEIN 2 are required for the function and blue-light suppression of degradation of CIB1.
Title: Arabidopsis CRY2 and ZTL mediate blue-light regulation of the transcription factor CIB1 by distinct mechanisms.
identification & characterization of CIB1 (At4g34530) protein; CIB1 interacts with CRY2 in a blue light-specific manner & acts with additional CIB1-related proteins to promote CRY2-dependent floral initiation; CIB1 stimulates FT messenger RNA expression.
Title: Photoexcited CRY2 interacts with CIB1 to regulate transcription and floral initiation in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_119618.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of flower development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in response to blue light	IDA Inferred from Direct Assay more info	PubMed
involved_in response to blue light	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: cryptochrome-interacting basic-helix-loop-helix 1

NP_195179.2

cryptochrome-interacting basic-helix-loop-helix 1 (CIB1); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT1G68920.2); Has 2243 Blast hits to 2231 proteins in 129 species: Archae - 0; Bacteria - 9; Metazoa - 30; Fungi - 27; Plants - 2139; Viruses - 0; Other Eukaryotes - 38 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

16498391..16500174

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119618.3 → NP_195179.2 cryptochrome-interacting basic-helix-loop-helix 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195179.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O65678, Q8GY61, Q8L851, Q8S3D9

UniProtKB/TrEMBL

A0A178V495, A0A5S9XZB2

Conserved Domains (1) summary

cd18919
Location:168 → 253

bHLH_AtBPE_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BIG PETAL (BPE) and similar proteins