CBL10 calcineurin B-like protein 10 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CBL10
Official Full Name: calcineurin B-like protein 10
Primary source: TAIR:AT4G33000
Locus tag: AT4G33000
See related: Araport:AT4G33000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCBL10; calcineurin B-like protein 10; F26P21.120; F26P21_120; SCABP8; SOS3-LIKE CALCIUM BINDING PROTEIN 8
Summary: Encodes a member of the calcineurin B-like calcium sensor gene family. Mediates salt tolerance by regulating ion homeostasis in Arabidopsis.
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Genomic context

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See CBL10 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 9

Sequence:: Chromosome: 4; NC_003075.7 (15924349..15926665)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The protein kinase complex CBL10-CIPK8-SOS1 functions in Arabidopsis to regulate salt tolerance.
Title: The protein kinase complex CBL10-CIPK8-SOS1 functions in Arabidopsis to regulate salt tolerance.
Duplication and functional divergence of a calcium sensor in the Brassicaceae.
Title: Duplication and functional divergence of a calcium sensor in the Brassicaceae.
S-acylation of CBL10/SCaBP8 by PAT10 is crucial for its tonoplast association and function in salt tolerance.
Title: S-acylation of CBL10/SCaBP8 by PAT10 is crucial for its tonoplast association and function in salt tolerance.
Interaction between CBL4 and CBL10 and found that the cbl4 cbl10 double mutant was dramatically more sensitive to salt as compared to the cbl4 and cbl10 single mutants, suggesting that CBL4 and CBL10 each directs a different salt-tolerance pathway.
Title: Calcineurin B-Like Proteins CBL4 and CBL10 Mediate Two Independent Salt Tolerance Pathways in Arabidopsis.
CBL10 is critical for reproductive development in the presence of salt and that it functions in different pathways during vegetative and reproductive development.
Title: Arabidopsis CALCINEURIN B-LIKE10 Functions Independently of the SOS Pathway during Reproductive Development in Saline Conditions.
CBL10 negatively affects tolerance to drought and is not mediated by abscisic acid-induced signaling. Ca(2+) signaling through CBL10 differently affects the response to abiotic stresses, partly by regulating BR sensitivity of plant tissues.
Title: Reverse function of ROS-induced CBL10 during salt and drought stress responses.
mutation of SCABP8 suppresses the ant-knockout salt-tolerant phenotype, implying that ANT functions as a negative transcriptional regulator of SCABP8 upon salt stress.
Title: Arabidopsis AINTEGUMENTA mediates salt tolerance by trans-repressing SCABP8.
The study revealed a CBL-interacting protein kinase-independent regulatory mechanism of calcineurin B-like proteins in which CBL10 directly regulates AKT1 activity and affects ion homeostasis in plant cells.
Title: Calcineurin B-like protein CBL10 directly interacts with AKT1 and modulates K+ homeostasis in Arabidopsis.
SCaBP8 phosphorylation is required for the activation of SOS1 and has a role in regulating salt tolerance in Arabidopsis.
Title: Phosphorylation of SOS3-LIKE CALCIUM BINDING PROTEIN8 by SOS2 protein kinase stabilizes their protein complex and regulates salt tolerance in Arabidopsis.
findings suggest that CBL10 and CIPK24 (SOS2) constitute a novel salt-tolerance pathway that regulates the sequestration/compartmentalization of Na(+) in plant cells
Title: The calcium sensor CBL10 mediates salt tolerance by regulating ion homeostasis in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001342191.1

Supported by ESTs:

NM_001342192.1

Supported by ESTs:

NM_001342193.1

Supported by ESTs:

NM_001342194.1

Supported by ESTs:

NM_119454.2

Supported by ESTs:

NM_179154.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hyperosmotic salinity response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plant-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: calcineurin B-like protein 10

NP_001320119.1

calcineurin B-like protein 10 (CBL10); CONTAINS InterPro DOMAIN/s: Recoverin (InterPro:IPR001125), EF-HAND 2 (InterPro:IPR018249), Calcineurin B protein (InterPro:IPR015757), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: calcineurin B-like 3 (TAIR:AT4G26570.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_195026.1

calcineurin B-like protein 10 (CBL10); CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), Recoverin (InterPro:IPR001125), EF-HAND 2 (InterPro:IPR018249), Calcineurin B protein (InterPro:IPR015757), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992); BEST Arabidopsis thaliana protein match is: calcineurin B-like 3 (TAIR:AT4G26570.1); Has 7647 Blast hits to 7617 proteins in 798 species: Archae - 0; Bacteria - 10; Metazoa - 3628; Fungi - 1210; Plants - 1915; Viruses - 0; Other Eukaryotes - 884 (source: NCBI BLink).

NP_849485.1

calcineurin B-like protein 10 (CBL10); CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), Recoverin (InterPro:IPR001125), EF-HAND 2 (InterPro:IPR018249), Calcineurin B protein (InterPro:IPR015757), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: calcineurin B-like 3 (TAIR:AT4G26570.1); Has 7642 Blast hits to 7612 proteins in 798 species: Archae - 0; Bacteria - 10; Metazoa - 3625; Fungi - 1210; Plants - 1913; Viruses - 0; Other Eukaryotes - 884 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

15924349..15926665

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119454.2 → NP_195026.1 calcineurin B-like protein 10 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195026.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O82641, Q2HIW7, Q7FRS8, Q8GYR3, Q8GZD7

UniProtKB/TrEMBL

M5BEI3, M5BEN2

Conserved Domains (1) summary

COG5126
Location:64 → 218

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001342192.1 → NP_001329201.1 calcineurin B-like protein 10 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B705

Conserved Domains (1) summary

COG5126
Location:54 → 191

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_179154.2 → NP_849485.1 calcineurin B-like protein 10 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849485.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UYF3, M5BFB5

Conserved Domains (1) summary

COG5126
Location:54 → 208

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001342193.1 → NP_001329200.1 calcineurin B-like protein 10 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B704
NM_001342191.1 → NP_001320119.1 calcineurin B-like protein 10 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UX95, B3H7L8
NM_001342194.1 → NP_001329199.1 calcineurin B-like protein 10 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B705

Conserved Domains (1) summary

COG5126
Location:54 → 191

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]