LAP2 Cytosol aminopeptidase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: LAP2
Official Full Name: Cytosol aminopeptidase family protein
Primary source: TAIR:AT4G30920
Locus tag: AT4G30920
See related: Araport:AT4G30920
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtLAP2; F6I18.170; F6I18_170; leucyl aminopeptidase 2
Summary: Encodes LAP2, an aminopeptidase playing key roles in senescence, stress response and amino acid turnover.
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Genomic context

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See LAP2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 10

Sequence:: Chromosome: 4; NC_003075.7 (15046457..15049438, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

M17.20 (AT4G30920) is specific towards non-polar and aromatic amino acids; is dually-targeted to mitochondria and chloroplasts; in chloroplasts M17.20 plays a role in amino acid recovery as a part of a multi-step peptidolytic cascade. [M17.20]
Title: A multi-step peptidolytic cascade for amino acid recovery in chloroplasts.
This work indicates an important in planta role for AtLAP2 contributing to a further understanding of the proteases having several implications in higher plants.
Title: Role of the Arabidopsis leucine aminopeptidase 2.
LAP2 (AT4G30920) influences cell wall metabolism and components of cell growth, photosynthesis, and nitrogen metabolism. Loss of function accelerates leaf senescence and renders plants more sensitive to various stresses.
Title: The Arabidopsis aminopeptidase LAP2 regulates plant growth, leaf longevity and stress response.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_119239.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables aminopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within leaf senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in vacuole	HDA more info	PubMed

General protein information

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Preferred Names: Cytosol aminopeptidase family protein

NP_194821.1

Cytosol aminopeptidase family protein; FUNCTIONS IN: manganese ion binding, metalloexopeptidase activity, aminopeptidase activity; INVOLVED IN: proteolysis, protein metabolic process; LOCATED IN: chloroplast, vacuole; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: Peptidase M17, leucyl aminopeptidase, C-terminal (InterPro:IPR000819), Peptidase M17, leucyl aminopeptidase, N-terminal (InterPro:IPR008283), Peptidase M17, leucyl aminopeptidase (InterPro:IPR011356); BEST Arabidopsis thaliana protein match is: Cytosol aminopeptidase family protein (TAIR:AT4G30910.1); Has 9817 Blast hits to 9813 proteins in 2024 species: Archae - 18; Bacteria - 5432; Metazoa - 663; Fungi - 36; Plants - 122; Viruses - 1; Other Eukaryotes - 3545 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

15046457..15049438 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119239.3 → NP_194821.1 Cytosol aminopeptidase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194821.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O65557, Q944P7

UniProtKB/TrEMBL

A0A5S9XXW6, A0A654FUF0

Conserved Domains (1) summary

PRK00913
Location:81 → 579

PRK00913; multifunctional aminopeptidase A; Provisional