Leucine-rich repeat transmembrane protein kinase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: Leucine-rich repeat transmembrane protein kinase family protein
Primary source: TAIR:AT4G28650
Locus tag: AT4G28650
See related: Araport:AT4G28650
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: PXL2; PXY-like2; T5F17.100; T5F17_100
Summary: Encodes one of the two putative eLRR kinase closely related to PXY (At1g08590/PXL1 and At4g28650/PXL2). Insertion mutants in either pxl1 or pxl2 do not exhibit an obvious phenotype in the stem; double-mutant combinations of a Col allele, of pxy (pxy-3) with pxl1 and pxl2, generate a more severe vascular phenotype than pxy-3 alone, suggesting that these genes act synergistically with PXY in regulating vascular-tissue development in the stem.
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 2

Sequence:: Chromosome: 4; NC_003075.7 (14143958..14147537, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It is hypothesized that MIK1 can also interact with CLE peptides and use the SERK family of proteins as a co-receptor for signal propagation. [MIK1].
Title: Expression, purification, and phylogenetic analysis of MDIS1-INTERACTING RECEPTOR-LIKE KINASE1 (MIK1).
Loss of function by T-DNA insertion in C-terminally encoded peptide receptor 2 (CEPR2) together with phloem intercalated with xylem (PXY) and PXY-Like 2 (PXL2) led to abscisic acid (ABA) hypersensitivity, while CEPR2 overexpression led to ABA insensitivity compared with the wild type, indicating the redundant and negative roles of CEPR2, PXY, and PXL2 in ABA signaling.
Title: CEPR2 phosphorylates and accelerates the degradation of PYR/PYLs in Arabidopsis.
CLE42 binding induces PXL2 interaction with SERK2.
Title: CLE42 binding induces PXL2 interaction with SERK2.
MDIS1-MIK is a cell-surface receptor heteromer on the pollen tube that perceives female attractant LURE1 in A. thaliana. LURE1 specifically binds the extracellular domains of MDIS1, MIK1 and MIK2, whereas mdis1 and mik1 mik2 mutant pollen tubes respond less sensitively to LURE1. [MIK1]
Title: A receptor heteromer mediates the male perception of female attractants in plants.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_119007.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phloem or xylem histogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen tube guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in procambium histogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in pollen tube	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Leucine-rich repeat transmembrane protein kinase family protein

NP_194594.1

Leucine-rich repeat transmembrane protein kinase family protein; FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, ATP binding; INVOLVED IN: transmembrane receptor protein tyrosine kinase signaling pathway, protein amino acid phosphorylation; LOCATED IN: endomembrane system; EXPRESSED IN: hypocotyl, root, guard cell; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich receptor-like protein kinase family protein (TAIR:AT1G08590.1); Has 236312 Blast hits to 142770 proteins in 4269 species: Archae - 150; Bacteria - 21752; Metazoa - 75925; Fungi - 11533; Plants - 97988; Viruses - 432; Other Eukaryotes - 28532 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

14143958..14147537 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119007.3 → NP_194594.1 Leucine-rich repeat transmembrane protein kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194594.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9M0G7

UniProtKB/TrEMBL

A0A178V5Y0, A0A5S9XYX1

Conserved Domains (2) summary

PLN00113
Location:27 → 986

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:334 → 354

LRR_RI; leucine-rich repeat [structural motif]