RPS2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RPS2
Primary source: Araport:AT4G26090
Locus tag: AT4G26090
See related: TAIR:AT4G26090
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: DISEASE RESISTANCE PROTEIN RPS2; F20B18.200; F20B18_200; RESISTANT TO P. SYRINGAE 2
Summary: Encodes a plasma membrane protein with leucine-rich repeat, leucine zipper, and P loop domains that confers resistance to Pseudomonas syringae infection by interacting with the avirulence gene avrRpt2. RPS2 protein interacts directly with plasma membrane associated protein RIN4 and this interaction is disrupted by avrRpt2.
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Genomic context

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See RPS2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (13224338..13227872)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Homeostasis of Arabidopsis R protein RPS2 is negatively regulated by the RING-type E3 ligase MUSE16.
Title: Homeostasis of Arabidopsis R protein RPS2 is negatively regulated by the RING-type E3 ligase MUSE16.
Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity.
Title: Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity.
Rps2 segregates for two expressed clades of alleles, one resistant and one susceptible. Plants with resistant Rps2 are not less fit than those with a susceptible Rps2 allele in the absence of disease. Instead, all alleles provide a fitness benefit relative to an artificial deletion because of the role of RPS2 as a negative regulator of defence.
Title: Genetic architecture and pleiotropy shape costs of Rps2-mediated resistance in Arabidopsis thaliana.
Our results indicate that AtMBD6 is involved in RNA-mediated gene silencing and it binds to RNA binding proteins like AtRPS2C, AtAGO4 and AtNTF2. AtMBD6 also interacts with histone deacetylase AtHDA6 that might have a role in chromatin condensation at the targets of RdDM
Title: AtMBD6, a methyl CpG binding domain protein, maintains gene silencing in Arabidopsis by interacting with RNA binding proteins.
MUSE13 and MUSE14 contribute to the turnover of nucleotide-binding domain and leucine-rich repeat-containing (NLR) immune receptors SNC1 and RPS2.
Title: Plant TRAF Proteins Regulate NLR Immune Receptor Turnover.
Site-directed mutagenesis in the putative catalytic triad of AvrRpm1 results in loss of both AvrRpm1-dependent virulence and AvrRpm1-mediated activation of RPM1 but causes the ability to activate the RPS2 nucleotide binding leucine-rich repeat sensor.
Title: AvrRpm1 missense mutations weakly activate RPS2-mediated immune response in Arabidopsis thaliana.
Tobacco rattle virus based virus-induce gene silencing which require RPS2-mediated resistance.
Title: Development of a virus-induced gene-silencing system for functional analysis of the RPS2-dependent resistance signalling pathways in Arabidopsis.
Two closely related RPM1-interacting proteins, RIN2 and RIN3, are characterized in A. thaliana.
Title: A duplicated pair of Arabidopsis RING-finger E3 ligases contribute to the RPM1- and RPS2-mediated hypersensitive response.
The fitness costs of disease resistance in A. thaliana plants homozygous for RPS2 or RPP5 are reported.
Title: A novel cost of R gene resistance in the presence of disease.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MASC_STS16338 (e-PCR)
- UniSTS:258866

Homology

Orthologs from OrthoDB

NM_118742.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ADP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NB-ARC domain-containing disease resistance protein

NP_194339.1

RESISTANT TO P. SYRINGAE 2 (RPS2); CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: RPS5-like 1 (TAIR:AT1G12210.1); Has 21906 Blast hits to 18242 proteins in 683 species: Archae - 18; Bacteria - 1169; Metazoa - 4701; Fungi - 258; Plants - 15223; Viruses - 0; Other Eukaryotes - 537 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

13224338..13227872

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118742.2 → NP_194339.1 NB-ARC domain-containing disease resistance protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194339.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O82096, Q42484, Q8L3R0, Q8L3W3, Q8L4X9, Q8L4Y0, Q8L587, Q8L5B3, Q8LKZ8, Q8LKZ9, Q8LL00, Q8LL01, Q9ASP5

UniProtKB/TrEMBL

A0A5S9XVY2, A0A654FSW4

Conserved Domains (4) summary

COG4886
Location:520 → 775

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:535 → 559

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:680 → 704

LRR_RI; leucine-rich repeat [structural motif]

pfam00931
Location:158 → 398

NB-ARC; NB-ARC domain