ATR1 P450 reductase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: ATR1
Official Full Name: P450 reductase 1
Primary source: TAIR:AT4G24520
Locus tag: AT4G24520
See related: Araport:AT4G24520
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AR1; ARABIDOPSIS CYTOCHROME REDUCTASE; F22K18.280; F22K18_280; P450 reductase 1
Summary: Encodes a cyp450 reductase likely to be involved in phenylpropanoid metabolism.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ATR1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 17

Sequence:: Chromosome: 4; NC_003075.7 (12662561..12667262, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability.
Title: G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_118585.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NADPH-hemoprotein reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables NADPH-hemoprotein reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phenylpropanoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: P450 reductase 1

NP_001190823.1

P450 reductase 1 (ATR1); CONTAINS InterPro DOMAIN/s: Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), FAD-binding, type 1 (InterPro:IPR003097), Flavodoxin/nitric oxide synthase (InterPro:IPR008254), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709), NADPH Cytochrome P450 Reductase (InterPro:IPR015702); BEST Arabidopsis thaliana protein match is: P450 reductase 2 (TAIR:AT4G30210.2).

NP_194183.1

P450 reductase 1 (ATR1); FUNCTIONS IN: NADPH-hemoprotein reductase activity; INVOLVED IN: response to oxidative stress, phenylpropanoid metabolic process; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Flavodoxin/nitric oxide synthase (InterPro:IPR008254), Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), FAD-binding, type 1 (InterPro:IPR003097), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709), NADPH Cytochrome P450 Reductase (InterPro:IPR015702); BEST Arabidopsis thaliana protein match is: P450 reductase 2 (TAIR:AT4G30210.2); Has 6349 Blast hits to 5969 proteins in 1541 species: Archae - 6; Bacteria - 2994; Metazoa - 1048; Fungi - 898; Plants - 566; Viruses - 0; Other Eukaryotes - 837 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

12662561..12667262 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001203894.1 → NP_001190823.1 P450 reductase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190823.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XW56, F4JQY4

Conserved Domains (3) summary

cd06204
Location:284 → 688

CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...

COG0369
Location:82 → 688

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

pfam00258
Location:87 → 226

Flavodoxin_1; Flavodoxin
NM_118585.4 → NP_194183.1 P450 reductase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194183.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q39035, Q9SB48

UniProtKB/TrEMBL

A0A178UWR2, A0A5S9XW56

Conserved Domains (2) summary

cd06204
Location:288 → 692

CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...

pfam00258
Location:87 → 230

Flavodoxin_1