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SGT1A phosphatase-like protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828457, updated on 18-Sep-2024

Summary

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Official Symbol
SGT1A
Official Full Name
phosphatase-like protein
Primary source
TAIR:AT4G23570
Locus tag
AT4G23570
See related
Araport:AT4G23570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F9D16.40; F9D16_40
Summary
Closely related to SGT1B, may function in SCF(TIR1) mediated protein degradation. AtSGT1a and AtSGT1b are functionally redundant in the resistance to pathogenes. AtSGT1b was more highly expressed than AtSGT1. The N-terminal TPR domain of AtSGT1a reduces the steady-state level of Arabidopsis SGT1 proteins whereas the same domain from AtSGT1b enhances SGT1 accumulation. The TPR domain is dispensable for SGT1 resistance. AtSGT1a is induced upon pathogen infection and can function in R gene-mediated resistance.
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Genomic context

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See SGT1A in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Sequence:
Chromosome: 4; NC_003075.7 (12299749..12302935)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene WRKY family transcription factor Neighboring gene glycosyl hydrolase 9B15 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of SGT1 in resistance protein accumulation in plant immunity. Azevedo C, et al. EMBO J, 2006 May 3. PMID 16619029, Free PMC Article
  2. Regulatory role of SGT1 in early R gene-mediated plant defenses. Austin MJ, et al. Science, 2002 Mar 15. PMID 11847308
  3. SRFR1 negatively regulates plant NB-LRR resistance protein accumulation to prevent autoimmunity. Li Y, et al. PLoS Pathog, 2010 Sep 16. PMID 20862316, Free PMC Article
  4. Structural and functional analysis of SGT1 reveals that its interaction with HSP90 is required for the accumulation of Rx, an R protein involved in plant immunity. Botër M, et al. Plant Cell, 2007 Nov. PMID 18032631, Free PMC Article
  5. The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance. Azevedo C, et al. Science, 2002 Mar 15. PMID 11847307

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nuclear magnetic resonance spectroscopy and mutational analyses of HSP90 revealed the nature of its binding with the CS domain of SGT1.
    Title: Structural and functional analysis of SGT1-HSP90 core complex required for innate immunity in plants.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001036627.2
NM_118488.6
NM_179098.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to auxin stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
acts_upstream_of_or_within defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo development ending in seed dormancy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
phosphatase-like protein
NP_001031704.1
  • SGT1A; CONTAINS InterPro DOMAIN/s: CS-like domain (InterPro:IPR007052), Tetratricopeptide-like helical (InterPro:IPR011990), SGS (InterPro:IPR007699), Tetratricopeptide repeat-containing (InterPro:IPR013026), HSP20-like chaperone (InterPro:IPR008978), Tetratricopeptide repeat (InterPro:IPR019734), CS domain (InterPro:IPR017447); BEST Arabidopsis thaliana protein match is: phosphatase-related (TAIR:AT4G11260.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_194088.1
  • SGT1A; FUNCTIONS IN: protein binding; INVOLVED IN: defense response, ubiquitin-dependent protein catabolic process, embryo development ending in seed dormancy; LOCATED IN: SCF ubiquitin ligase complex, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), SGS (InterPro:IPR007699), HSP20-like chaperone (InterPro:IPR008978), CS domain (InterPro:IPR017447), CS-like domain (InterPro:IPR007052), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: phosphatase-related (TAIR:AT4G11260.1); Has 12440 Blast hits to 8629 proteins in 714 species: Archae - 442; Bacteria - 3949; Metazoa - 2875; Fungi - 1120; Plants - 1288; Viruses - 0; Other Eukaryotes - 2766 (source: NCBI BLink).
NP_849429.1
  • SGT1A; FUNCTIONS IN: protein binding; INVOLVED IN: defense response, ubiquitin-dependent protein catabolic process, embryo development ending in seed dormancy; LOCATED IN: SCF ubiquitin ligase complex, nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), SGS (InterPro:IPR007699), HSP20-like chaperone (InterPro:IPR008978), CS domain (InterPro:IPR017447), CS-like domain (InterPro:IPR007052), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: phosphatase-related (TAIR:AT4G11260.1); Has 12440 Blast hits to 8629 proteins in 714 species: Archae - 442; Bacteria - 3949; Metazoa - 2875; Fungi - 1120; Plants - 1288; Viruses - 0; Other Eukaryotes - 2766 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    12299749..12302935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_179098.3 → NP_849429.1  phosphatase-like protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849429.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q84LL4, Q8W515, Q9SUR9
    UniProtKB/TrEMBL
    A0A178UUN8
    Conserved Domains (5) summary
    cd06466
    Location:155 → 238
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    PLN03088
    Location:1 → 350
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:35 → 65
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:36 → 68
    TPR_1; Tetratricopeptide repeat
    pfam05002
    Location:268 → 348
    SGS; SGS domain

  2. NM_118488.6 → NP_194088.1  phosphatase-like protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_194088.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q84LL4, Q8W515, Q9SUR9
    UniProtKB/TrEMBL
    A0A178UUN8
    Conserved Domains (5) summary
    cd06466
    Location:155 → 238
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    PLN03088
    Location:1 → 350
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:35 → 65
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:36 → 68
    TPR_1; Tetratricopeptide repeat
    pfam05002
    Location:268 → 348
    SGS; SGS domain

  3. NM_001036627.2 → NP_001031704.1  phosphatase-like protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031704.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9XVM6, A0A654FSC1
    Conserved Domains (4) summary
    cd06466
    Location:156 → 239
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    PLN03088
    Location:1 → 351
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:35 → 66
    TPR; TPR repeat [structural motif]
    pfam05002
    Location:269 → 349
    SGS; SGS domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SUR9.1

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