CBL1 calcineurin B-like protein 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CBL1
Official Full Name: calcineurin B-like protein 1
Primary source: TAIR:AT4G17615
Locus tag: AT4G17615
See related: Araport:AT4G17615
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA CALCINEURIN B-LIKE PROTEIN; ATCBL1; calcineurin B-like protein 1; FCAALL.122; SCABP5; SOS3-LIKE CALCIUM BINDING PROTEIN 5
Summary: Member of AtCBL (Calcineurin B-like Calcium Sensor Proteins) family. Protein level is increased upon high salt, mannitol, and cold stresses. CBL1 interacts with CIPK23 and recruits the kinase to the plasma membrane where the substrate(s) of CIPK23 may reside. CBL1 localization is regulated by protein modification including myristolation and acylation.
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Genomic context

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See CBL1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 9

Sequence:: Chromosome: 4; NC_003075.7 (9816278..9819368)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calcium binding of AtCBL1: Structural and functional insights.
Title: Calcium binding of AtCBL1: Structural and functional insights.
CBL1/9-CIPK23-NRAMP1 axis regulates manganese toxicity.
Title: CBL1/9-CIPK23-NRAMP1 axis regulates manganese toxicity.
A novel role of the calcium sensor CBL1 in response to phosphate deficiency in Arabidopsis thaliana.
Title: A novel role of the calcium sensor CBL1 in response to phosphate deficiency in Arabidopsis thaliana.
These analyses reveal not only the fundamental role of CBL1 in the adjustment of central transcriptomic networks involved in maintaining adequate physiological homeostasis processes, but also that a high shoot-root dynamics is required for the proper deployment of Al resistance responses in the root.
Title: Loss-of-function mutation of the calcium sensor CBL1 increases aluminum sensitivity in Arabidopsis.
Data indicate that both voltage-dependent anion channel 1 (AtVDAC1) and calcium sensor CBL1 regulate cold stress responses during seed germination and plant development.
Title: The voltage-dependent anion channel 1 (AtVDAC1) negatively regulates plant cold responses during germination and seedling development in Arabidopsis and interacts with calcium sensor CBL1.
a crucial function for CBL1 and CBL9 in pollen germination and tube growth
Title: The calcineurin B-like Ca2+ sensors CBL1 and CBL9 function in pollen germination and pollen tube growth in Arabidopsis.
These results indicate a novel role for CBL1 in modulating responses to glucose and gibberellic acid signals.
Title: A novel role for Arabidopsis CBL1 in affecting plant responses to glucose and gibberellin during germination and seedling development.
a novel general regulatory mechanism of CBL-CIPK complexes in that CBL phosphorylation at their flexible C terminus likely provokes conformational changes that enhance specificity and activity of CBL-CIPK complexes toward their target proteins
Title: Phosphorylation of calcineurin B-like (CBL) calcium sensor proteins by their CBL-interacting protein kinases (CIPKs) is required for full activity of CBL-CIPK complexes toward their target proteins.
These findings provide further insights into the signaling network consisting of CBL-CIPK-PP2C interactions in the activation of the AKT1 channel.
Title: Mechanistic analysis of AKT1 regulation by the CBL-CIPK-PP2CA interactions.
Deletion of CBL1 may disturb the perception of calcium influx by cold stress and results in altered cold-induced signaling and adaption.
Title: CIPK7 is involved in cold response by interacting with CBL1 in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001341236.1

Supported by ESTs:

NM_001341237.1

Supported by ESTs:

NM_001341238.1

Supported by ESTs:

NM_117870.4

Supported by ESTs:

NM_202837.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within abscisic acid-activated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within calcium-mediated signaling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular response to phosphate starvation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen tube growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within potassium ion import across plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to osmotic stress	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stomatal movement	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in pollen tube	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcineurin B-like protein 1

NP_567533.1

calcineurin B-like protein 1 (CBL1); FUNCTIONS IN: calcium ion binding; INVOLVED IN: in 9 processes; LOCATED IN: plasma membrane, cytoplasm; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), Calcineurin B protein (InterPro:IPR015757), Recoverin (InterPro:IPR001125), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: calcineurin B-like protein 9 (TAIR:AT5G47100.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_974566.1

calcineurin B-like protein 1 (CBL1); FUNCTIONS IN: calcium ion binding; INVOLVED IN: in 8 processes; LOCATED IN: plasma membrane, cytoplasm; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), Recoverin (InterPro:IPR001125), EF-HAND 2 (InterPro:IPR018249), Calcineurin B protein (InterPro:IPR015757), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: calcineurin B-like protein 9 (TAIR:AT5G47100.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

9816278..9819368

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117870.4 → NP_567533.1 calcineurin B-like protein 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567533.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O23603, O81445

UniProtKB/TrEMBL

A0A178UV60, A0A5S9XTH4

Conserved Domains (1) summary

COG5126
Location:25 → 183

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001341236.1 → NP_001329533.1 calcineurin B-like protein 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B7Z8
NM_001341237.1 → NP_001329535.1 calcineurin B-like protein 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O23603, O81445

UniProtKB/TrEMBL

A0A178UV60, A0A5S9XTH4

Conserved Domains (1) summary

COG5126
Location:25 → 183

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_202837.1 → NP_974566.1 calcineurin B-like protein 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974566.1

Status: REVIEWED

UniProtKB/TrEMBL

F4JP88

Conserved Domains (3) summary

cd00051
Location:66 → 135

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:67 → 130

EF-hand_7; EF-hand domain pair

cl08302
Location:32 → 91

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001341238.1 → NP_001329534.1 calcineurin B-like protein 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O23603, O81445

UniProtKB/TrEMBL

A0A178UV60, A0A5S9XTH4

Conserved Domains (1) summary

COG5126
Location:25 → 183

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]