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MOS6 ARM repeat superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 827472, updated on 18-Sep-2024

Summary

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Official Symbol
MOS6
Official Full Name
ARM repeat superfamily protein
Primary source
TAIR:AT4G02150
Locus tag
AT4G02150
See related
Araport:AT4G02150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
6; ATIMPALPHA3; IMPA-3; IMPORTIN ALPHA 3; IMPORTIN ALPHA ISOFORM 3; MODIFIER OF SNC1; T10M13.16; T10M13_16
Summary
Encodes IMPORTIN ALPHA 3. Mutant plants act as suppressors of snc1 response and salicylic acid accumulation. Located in the nucleus. Involved in protein import. Protein interacts with Agrobacterium proteins VirD2 and VirE2. Is not individually essential for Agrobacterium-mediated root transformation, but when overexpressed can rescue the impa-4 decreased transformation susceptibility phenotype.
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Genomic context

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See MOS6 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Sequence:
Chromosome: 4; NC_003075.7 (950546..953690, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene CTP synthase family protein Neighboring gene galacturonosyltransferase 6 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene cotton fiber protein Neighboring gene cotton fiber protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Probing formation of cargo/importin-α transport complexes in plant cells using a pathogen effector. Wirthmueller L, et al. Plant J, 2015 Jan. PMID 25284001, Free PMC Article
  2. An importin alpha homolog, MOS6, plays an important role in plant innate immunity. Palma K, et al. Curr Biol, 2005 Jun 21. PMID 15964279
  3. Functional requirement of the Arabidopsis importin-α nuclear transport receptor family in autoimmunity mediated by the NLR protein SNC1. Lüdke D, et al. Plant J, 2021 Feb. PMID 33210758
  4. The truncated NLR protein TIR-NBS13 is a MOS6/IMPORTIN-α3 interaction partner required for plant immunity. Roth C, et al. Plant J, 2017 Dec. PMID 28901644
  5. Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis. Németh K, et al. Genes Dev, 1998 Oct 1. PMID 9765207, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional requirement of the Arabidopsis importin-alpha nuclear transport receptor family in autoimmunity mediated by the NLR protein SNC1.
    Title: Functional requirement of the Arabidopsis importin-α nuclear transport receptor family in autoimmunity mediated by the NLR protein SNC1.
  2. MOS6, identified by positional cloning, encodes importin alpha3, one of eight alpha importins in Arabidopsis [MOS6]
    Title: An importin alpha homolog, MOS6, plays an important role in plant innate immunity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001340367.1
NM_116447.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ARM repeat superfamily protein
NP_192124.1
  • MODIFIER OF SNC1, 6 (MOS6); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, defense response; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 6 (TAIR:AT1G02690.1); Has 4718 Blast hits to 3432 proteins in 305 species: Archae - 4; Bacteria - 22; Metazoa - 2034; Fungi - 556; Plants - 1321; Viruses - 0; Other Eukaryotes - 781 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    950546..953690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_116447.3 → NP_192124.1  ARM repeat superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_192124.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04255, O04294, O49601, Q4JHM3, Q94F55
    UniProtKB/TrEMBL
    A0A178V578, A0A5S9XP37, A0A654FL77
    Conserved Domains (2) summary
    COG5064
    Location:10 → 529
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:247 → 272
    ARM; armadillo repeat [structural motif]

  2. NM_001340367.1 → NP_001328074.1  ARM repeat superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B3H5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O04294.2

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