LOS4 P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: LOS4
Official Full Name: P-loop containing nucleoside triphosphate hydrolases superfamily protein
Primary source: TAIR:AT3G53110
Locus tag: AT3G53110
See related: Araport:AT3G53110
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: LOW EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 4
Summary: Encodes a putative DEAD-Box RNA Helicase and has RNA-dependent ATPase activity. Mutant is Sensitive to chilling stress and heat stress. Germination of the mutant is inhibited by ABA. LOS4 may be involved in temperature sensing. Is enriched in the nuclear envelope and also located in the cytoplasm. LOS4 is involved in export of poly A RNA.
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Genomic context

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See LOS4 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 9

Sequence:: Chromosome: 3; NC_003074.8 (19687740..19690661)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRYOPHYTE/LOS4 RNA helicase plays an important role in mRNA export, plant development, and stress responses. [LOS4]
Title: A DEAD box RNA helicase is essential for mRNA export and important for development and stress responses in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_115171.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP-dependent activity, acting on RNA	IDA Inferred from Direct Assay more info	PubMed
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within poly(A)+ mRNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: P-loop containing nucleoside triphosphate hydrolases superfamily protein

NP_190879.1

LOW EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 4 (LOS4); FUNCTIONS IN: RNA helicase activity, RNA-dependent ATPase activity, ATP-dependent helicase activity; INVOLVED IN: poly(A)+ mRNA export from nucleus, response to cold, response to heat, response to abscisic acid stimulus; LOCATED IN: nuclear envelope, plasma membrane, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: eukaryotic initiation factor 4A-III (TAIR:AT3G19760.1); Has 40925 Blast hits to 40635 proteins in 3033 species: Archae - 702; Bacteria - 21081; Metazoa - 5720; Fungi - 4311; Plants - 2419; Viruses - 28; Other Eukaryotes - 6664 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

19687740..19690661

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_115171.3 → NP_190879.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_190879.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93ZG7, Q9SCQ0

UniProtKB/TrEMBL

A0A178VC43, A0A5S9XKL9

Conserved Domains (2) summary

COG0513
Location:73 → 490

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd17963
Location:98 → 301

DEADc_DDX19_DDX25; DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25